History and pathogenesis of lynch syndrome.

Abstract:

:Lynch syndrome is the familial clustering of colorectal and endometrial cancers. This syndrome is passed in an autosomal dominant fashion within families with defective mismatch repair as the genetic basis for cancer development in these patients. There remains a group of patients who fit clinical diagnostic criteria for an autosomal dominant familial cancer syndrome, which is phenotypically similar to Lynch syndrome, but for which no mismatch repair mutation is identified. Identification of alternate genetic mutations such as EPCAM and CHEK2 may explain the cancer risk in a small subset of these patients, but continuing work into the genetic basis of colorectal familial cancer syndromes is needed.

journal_name

Clin Colon Rectal Surg

authors

Bansidhar BJ,Silinsky J

doi

10.1055/s-0032-1313776

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

63-6

issue

2

eissn

1531-0043

issn

1530-9681

pii

25063

journal_volume

25

pub_type

杂志文章
  • Laparoscopic colectomy for colon cancer: comparable to conventional oncologic surgery?

    abstract::As a result of the obvious benefits of laparoscopic cholecystectomy, minimally invasive techniques have been applied to more complex gastrointestinal procedures, including colorectal resections. The goal in adapting laparoscopic techniques for colorectal surgery is to offer an operation that results in less pain, shor...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2005-916278

    authors: Bonnor RM,Ludwig KA

    更新日期:2005-08-01 00:00:00

  • Locally Advanced Disease and Pelvic Exenterations.

    abstract::Advanced primary and recurrent colorectal cancer can be successfully treated by experienced, dedicated centers delivering good outcomes with low mortality and morbidity. Development and implementation of a comprehensive referral pathway is to be encouraged. Multidisciplinary team management is essential in the managem...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1606118

    authors: Kontovounisios C,Tekkis P

    更新日期:2017-11-01 00:00:00

  • How Can Social Media Get Us in Trouble?

    abstract::When utilized properly, social media offers several personal and professional benefits for the practicing surgeon, including peer networking, education, e-mentorship, marketing, recruitment, and patient outreach. However, unprofessional online behavior is common among surgeons, and this improper use of social media ca...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1604255

    authors: Langenfeld SJ,Batra R

    更新日期:2017-09-01 00:00:00

  • Laparoscopy for inflammatory bowel disease: pushing the envelope.

    abstract::Despite the slower learning curve of laparoscopic colectomy and the lack of prospective randomized trials, laparoscopic procedures have repeatedly demonstrated a shortened length of stay, reduction in postoperative ileus, and earlier resumption of diet. However, laparoscopy in inflammatory bowel disease has unique cha...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2006-939528

    authors: Marcello PW

    更新日期:2006-02-01 00:00:00

  • Computed tomography colonography (virtual colonoscopy): climax of a new era of validation and transition into community practice.

    abstract::Colorectal cancer, which kills more than 50,000 patients every year in the United States and costs more than $6 billion in direct health costs, is a prime target for cancer prevention. Computed tomography colonography (CTC) has emerged as a minimally invasive, structural examination of the entire colon that can comple...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2008-1081001

    authors: Thomas J,Carenza J,McFarland E

    更新日期:2008-08-01 00:00:00

  • Surgical hemorrhage, damage control, and the abdominal compartment syndrome.

    abstract::The morbidity and mortality associated with surgical hemorrhage are considerable, particularly when relaparotomy is necessary. This complication can usually be avoided with comprehensive preoperative patient evaluation and meticulous surgical technique. The damage control sequence is a useful surgical strategy when se...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2006-956439

    authors: Hammond KL,Margolin DA

    更新日期:2006-11-01 00:00:00

  • Transanal Minimally Invasive Surgery.

    abstract::Transanal minimally invasive surgery (TAMIS) was first described in 2010 as a crossover between single-incision laparoscopic surgery and transanal endoscopic microsurgery (TEM) to allow access to the proximal and mid-rectum for resection of benign and early-stage malignant rectal lesions. The TAMIS technique can also ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0035-1555008

    authors: deBeche-Adams T,Nassif G

    更新日期:2015-09-01 00:00:00

  • Evidence-based medicine in surgical education.

    abstract::Evidence-based medicine (EBM) is increasingly important for clinical surgery and for promotion of best practices into surgical decision making. Although barriers exist in the current surgical literature, for certain surgical scenarios, formal efforts to promote evidence-based surgery (EBS) into surgical education are ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0032-1322552

    authors: Kwaan MR,Melton GB

    更新日期:2012-09-01 00:00:00

  • Diverticular disease and the obese patient.

    abstract::Diverticular disease is common in the Western world and is a considerable source of morbidity. Many have proposed an association between diverticular disease, its complications, and obesity. We examine this question through a review of the available literature. While it is likely that an association between diverticul...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0031-1295688

    authors: Johnson EK,Champagne BJ

    更新日期:2011-12-01 00:00:00

  • Premalignant lesions of the anal canal and squamous cell carcinoma of the anal canal.

    abstract::Squamous cell carcinoma of the anus (SCCA) is a rare tumor. However, its incidence has been increasing in men and women over the past 25 years worldwide. Risk factors associated with this cancer are those behaviors that predispose individuals to human papillomavirus (HPV) infection and immunosuppression. Anal cancer i...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0031-1286002

    authors: Poggio JL

    更新日期:2011-09-01 00:00:00

  • Update on Sporadic Colorectal Cancer Genetics.

    abstract::Our understanding of the genetics of colorectal cancer has changed dramatically over recent years. Colorectal cancer can be classified in multiple different ways. Along with the advent of whole-exome sequencing, we have gained an understanding of the scale of the genetic changes found in sporadic colorectal cancer. We...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1602234

    authors: Hardiman KM

    更新日期:2018-05-01 00:00:00

  • Inherited colorectal cancer syndromes.

    abstract::Colorectal cancer is common in the Western world; ~5% of individuals diagnosed with colorectal cancer have an identifiable inherited genetic predisposition to this malignancy. Genetic testing and rational clinical management recommendations currently exist for the management of individuals with a variety of colorectal...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0029-1242459

    authors: Gryfe R

    更新日期:2009-11-01 00:00:00

  • Use of intra-abdominal drains.

    abstract::The use of drains in colorectal surgery has been a subject of debate for several decades. Prophylactic drainage of the peritoneal cavity has become less popular in recent years. This change is due to several studies demonstrating that intraperitoneal drains do not adequately drain the peritoneal cavity and do not prev...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0033-1351134

    authors: Puleo FJ,Mishra N,Hall JF

    更新日期:2013-09-01 00:00:00

  • Current Status of Segmental Colectomy in Select Crohn's Disease Patients.

    abstract::Crohn's disease is a complex disease with a varying clinical and anatomical spectrum. One-third of patients with Crohn's will have disease confined to the colon. In this article, the authors review the surgical treatment options for colonic Crohn's disease including the current status of performing segmental colectomy...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-1683906

    authors: Heriot A,Smart P

    更新日期:2019-07-01 00:00:00

  • Intestinal Intussusception: Etiology, Diagnosis, and Treatment.

    abstract::Intussusception is defined as the invagination of one segment of the bowel into an immediately adjacent segment of the bowel. Idiopathic ileocolic intussusception is the most common form in children and is typically managed with nonoperative reduction via pneumatic and/or hydrostatic enemas. In the adult population, i...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1593429

    authors: Marsicovetere P,Ivatury SJ,White B,Holubar SD

    更新日期:2017-02-01 00:00:00

  • Postoperative Complications: Looking Forward to a Safer Future.

    abstract::Colorectal surgery patients frequently suffer from postoperative complications. Patients with complications have been shown to be at higher risk for mortality, poor oncologic outcomes, additional complications, and worse quality of life. Complications are increasingly recognized as markers of quality of care with more...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1584501

    authors: Tevis SE,Kennedy GD

    更新日期:2016-09-01 00:00:00

  • Colorectal lymphoma.

    abstract::Lymphoma involving the colon and rectum is rare and can occur either as primary colorectal lymphoma or as a manifestation of systemic disease. Most patients with primary colorectal lymphoma present with abdominal pain, and obstruction is unusual. Although lesions may be evident on radiographic studies, the findings ar...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2006-942344

    authors: Quayle FJ,Lowney JK

    更新日期:2006-05-01 00:00:00

  • Management of colonic obstruction: a review.

    abstract::Large bowel obstruction is a common problem with many different causes, the most common being colorectal adenocarcinoma, extracolonic adenocarcinoma, diverticular disease, volvulus, and inflammatory bowel disease. The nature of the obstruction can influence the best management. Historically, treatment of obstruction c...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0032-1329533

    authors: Sawai RS

    更新日期:2012-12-01 00:00:00

  • Role of professional societies in career development.

    abstract::Professional medical societies serve several functions that may benefit society, the sponsoring medical profession, and individual members. Several professional societies are available for colorectal surgeons to join and participate in. Reasons to join include service, educational offerings, networking, and companions...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0031-1278406

    authors: Beck DE

    更新日期:2011-06-01 00:00:00

  • Is There Any Reason to Still Consider Lateral Lymph Node Dissection in Rectal Cancer? Rationale and Technique.

    abstract::Nodal dissemination in locally advanced rectal cancer occurs mainly in two directions: upward and lateral. Lateral node involvement has been demonstrated; however, lateral lymph node dissection (LLND) is not routinely performed in Western countries and the focus is more on neoadjuvant treatment regimens. The main reas...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0037-1606112

    authors: Kusters M,Uehara K,Velde CJHV,Moriya Y

    更新日期:2017-11-01 00:00:00

  • Learning Transanal Total Mesorectal Excision.

    abstract::A dynamic evolution is occurring in transanal surgery. Transanal techniques began with intraluminal surgical removal of rectal masses and have progressed to transanal total mesorectal excision (taTME) for rectal cancer. TaTME was first performed in 2009 by Sylla, Rattner, Delgado, and Lacy. This article documents the ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0039-3402779

    authors: McLemore EC,Lavi P,Attaluri V

    更新日期:2020-05-01 00:00:00

  • Imaging of colonic diverticular disease.

    abstract::Diverticular disease affects approximately two thirds of the population over the age of 70. While only a small fraction of these patients will develop diverticulitis, adequate radiological evaluation of diverticulitis and its complications is imperative in determining proper medical and surgical treatment. Clinical ex...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2004-832696

    authors: Snyder MJ

    更新日期:2004-08-01 00:00:00

  • Paradoxical puborectalis contraction and increased perineal descent.

    abstract::Paradoxical puborectalis contraction and increased perineal descent are two forms of functional constipation presenting as challenging diagnostic and treatment dilemmas to the clinician. In the evaluation of these disorders, the clinician should take special care to exclude anatomic disorders leading to constipation. ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-2008-1075863

    authors: Landmann RG,Wexner SD

    更新日期:2008-05-01 00:00:00

  • Genitourinary Considerations in Reoperative and Complex Colorectal Surgery.

    abstract::Genitourinary structures are at risk of injury during colorectal surgery. The incidence of injury is low; however, the risk is higher in cases involving severe inflammatory or infectious processes, locally advanced or recurrent cancer, previous radiation, and reoperation. Consideration of the anatomical relationship b...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1580629

    authors: Althumairi AA,Efron JE

    更新日期:2016-06-01 00:00:00

  • Laparoscopy for Colon Cancer.

    abstract::The use of laparoscopy has become widespread across many surgical specialties. Its utility as treatment for colon cancer was initially met with hesitancy due to concern for port site and wound recurrences; however, this was later disproven by large retrospective series. Subsequently, there have been multiple, large, p...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1597317

    authors: Franklin BR,McNally MP

    更新日期:2017-04-01 00:00:00

  • Management of the malignant polyp.

    abstract::In the United States, the prevalence of adenomatous polyps found during colonoscopic evaluation ranges from 25 to 41%, and of these, 2 to 5% contain invasive malignancy. The management of the malignant polyp continues to be challenging. Endoscopic resection by polypectomy has been shown to be sufficient for management...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0028-1089944

    authors: Ramirez M,Schierling S,Papaconstantinou HT,Thomas JS

    更新日期:2008-11-01 00:00:00

  • Hemorrhoids.

    abstract::Hemorrhoid disease is the most common reason patients seek evaluation by a colon and rectal surgeon. The majority of hemorrhoids can be managed nonoperatively with medical management or office-based procedures. The authors review the anatomy, pathophysiology, presentation, and management of hemorrhoids. ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0031-1272818

    authors: Sanchez C,Chinn BT

    更新日期:2011-03-01 00:00:00

  • Participation in quality measurement nationwide.

    abstract::In the interest of improving patient care quality and reducing costs, many hospitals across the nation participate in quality measurements. The three programs most applicable to colon and rectal surgery are the National Surgical Quality Improvement Project, the Surgical Care Improvement Project (SCIP), and the Surgica...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0034-1366914

    authors: Irani JL

    更新日期:2014-03-01 00:00:00

  • Preoperative evaluation and risk management.

    abstract::All colorectal operations carry significant associated risk. To facilitate the best outcomes it is essential to perform a comprehensive evaluation of patient risk preoperatively. Once risk factors are identified the appropriate steps must be taken to minimize their effects. The evaluation of the patient can be broken ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章

    doi:10.1055/s-0029-1202870

    authors: Parsons DP

    更新日期:2009-02-01 00:00:00

  • Colonic Polyps: Diagnosis and Surveillance.

    abstract::Colorectal cancer begins as a polyp that is a benign growth on the mucosal surface of the colon or rectum. Over a period of 5 to 15 years, polyps can degenerate into a cancer, thus invading the colonic wall. Colorectal screening methods are designed to diagnose and remove polyps before they acquire invasive potential ...

    journal_title:Clinics in colon and rectal surgery

    pub_type: 杂志文章,评审

    doi:10.1055/s-0036-1584091

    authors: Huck MB,Bohl JL

    更新日期:2016-12-01 00:00:00