Factors that influence parathyroid hormone half-life: determining if new intraoperative criteria are needed.

Abstract:

IMPORTANCE:Minimally invasive parathyroidectomy using intraoperative parathyroid hormone monitoring remains the standard approach to the majority of patients with primary hyperparathyroidism. This study demonstrates that individual patient characteristics do not affect existing criteria for intraoperative parathyroid hormone monitoring. OBJECTIVE:To identify patient characteristics, such as age, sex, race, body mass index (BMI), and renal function, that may affect existing criteria for intraoperative parathyroid hormone (IOPTH) levels during minimally invasive parathyroidectomy. DESIGN:Retrospective review of a prospectively collected parathyroid database populated from August 2005 to April 2011. SETTING:Academic medical center. PARTICIPANTS:Three hundred six patients with sporadic primary hyperparathyroidism who underwent initial parathyroidectomy between August 2005 and April 2011. INTERVENTIONS:All patients underwent minimally invasive parathyroidectomy with complete IOPTH information. MAIN OUTCOME AND MEASURES:Individual IOPTH kinetic profiles were fitted with an exponential decay curve and individual IOPTH half-lives were determined. Univariate and multivariate analyses were performed to determine the association between patient demographics or laboratory data and IOPTH half-life. RESULTS:Mean age of the cohort was 60 years, 78.4% were female, 90.2% were white, and median BMI was 28.3. Overall, median IOPTH half-life was 3 minutes, 9 seconds. On univariate analysis, there was no association between IOPTH half-life and patient age, renal function, or preoperative serum calcium or parathyroid hormone levels. Age, BMI, and an age × BMI interaction were included in the final multivariate median regression analysis; race, sex, and glomerular filtration rate were not predictors of IOPTH half-life. The IOPTH half-life increased with increasing BMI, an effect that diminished with increasing age and was negligible after age 55 years (P = .001). CONCLUSIONS AND RELEVANCE:Body mass index, especially in younger patients, may have a role in the IOPTH half-life of patients undergoing parathyroidectomy. However, the differences in half-life are relatively small and the clinical implications are likely not significant. Current IOPTH criteria can continue to be applied to all patients undergoing parathyroidectomy for sporadic primary hyperparathyroidism.

journal_name

JAMA Surg

journal_title

JAMA surgery

authors

Leiker AJ,Yen TW,Eastwood DC,Doffek KM,Szabo A,Evans DB,Wang TS

doi

10.1001/jamasurg.2013.104

subject

Has Abstract

pub_date

2013-07-01 00:00:00

pages

602-6

issue

7

eissn

2168-6254

issn

2168-6262

pii

1686275

journal_volume

148

pub_type

杂志文章
  • Neonates with short bowel syndrome: an optimistic future for parenteral nutrition independence.

    abstract:IMPORTANCE:The introduction of hepatoprotective strategies and multidisciplinary management has significantly improved the outcome of neonates with short bowel syndrome (SBS) who require parenteral nutrition (PN). OBJECTIVE:To determine the probability of weaning from PN based on intestinal length in neonates with SBS...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2013.4332

    authors: Fallon EM,Mitchell PD,Nehra D,Potemkin AK,O'Loughlin AA,Gura KM,Puder M

    更新日期:2014-07-01 00:00:00

  • Trends in Outcomes for Marginal Allografts in Liver Transplant.

    abstract:Importance:Investigating outcomes after marginal allograft transplant is essential in determining appropriate and more aggressive use of these allografts. Objective:To determine the time trends in the outcomes of marginal liver allografts as defined by 6 different sets of criteria. Design, Setting, and Participants:I...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2020.2484

    authors: Zhang T,Dunson J,Kanwal F,Galvan NTN,Vierling JM,O'Mahony C,Goss JA,Rana A

    更新日期:2020-08-05 00:00:00

  • Factors Associated With Interhospital Variability in Inpatient Costs of Liver and Pancreatic Resections.

    abstract:IMPORTANCE:In an era of accountable care, understanding variation in health care costs is critical to reducing health care spending. OBJECTIVE:To identify factors associated with increased hospital costs and quantify variations in costs among individual hospitals in patients undergoing liver and pancreatic surgery in ...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2015.3618

    authors: Nelson-Williams H,Gani F,Kilic A,Spolverato G,Kim Y,Wagner D,Amini N,Ejaz A,Pawlik TM

    更新日期:2016-02-01 00:00:00

  • Association of Decreased Postsurgical Opioid Prescribing With Patients' Satisfaction With Surgeons.

    abstract:Importance:Opioid overdose is the leading cause of injury-related death in the United States. Several studies have shown that surgeons overprescribe opioids, and guidelines for appropriate opioid prescribing are available. Concern about patient-reported satisfaction scores may be a barrier to surgeons adopting guidelin...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2019.2875

    authors: Louie CE,Kelly JL,Barth RJ Jr

    更新日期:2019-11-01 00:00:00

  • Career Goals, Salary Expectations, and Salary Negotiation Among Male and Female General Surgery Residents.

    abstract:Importance:In general surgery, women earn less money and hold fewer leadership positions compared with their male counterparts. Objective:To assess whether differences exist between the perspectives of male and female general surgery residents on future career goals, salary expectations, and salary negotiation that ma...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2019.2879

    authors: Gray K,Neville A,Kaji AH,Wolfe M,Calhoun K,Amersi F,Donahue T,Arnell T,Jarman B,Inaba K,Melcher M,Morris JB,Smith B,Reeves M,Gauvin J,Salcedo ES,Sidwell R,Murayama K,Damewood R,Poola VP,Dent D,de Virgilio C

    更新日期:2019-11-01 00:00:00

  • Determining whether excision of all fibroepithelial lesions of the breast is needed to exclude phyllodes tumor: upgrade rate of fibroepithelial lesions of the breast to phyllodes tumor.

    abstract::Fibroepithelial lesions (FELs) are a common histologic finding on core needle biopsy (CNB) of the breast. Fibroepithelial lesions include fibroadenoma and phyllodes tumor, which can be difficult to distinguish with an initial CNB. An institutional experience was reviewed from February 12, 2001, to January 4, 2007, to ...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2014.73

    authors: Van Osdol AD,Landercasper J,Andersen JJ,Ellis RL,Gensch EM,Johnson JM,De Maiffe B,Marcou KA,Al-Hamadani M,Vang CA

    更新日期:2014-10-01 00:00:00

  • Lung Cancer Resection at Hospitals With High vs Low Mortality Rates.

    abstract:IMPORTANCE:Wide variations in mortality rates exist across hospitals following lung cancer resection; however, the factors underlying these differences remain unclear. OBJECTIVE:To evaluate perioperative outcomes in patients who underwent lung cancer resection at hospitals with very high and very low mortality rates (...

    journal_title:JAMA surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamasurg.2015.2199

    authors: Grenda TR,Revels SL,Yin H,Birkmeyer JD,Wong SL

    更新日期:2015-11-01 00:00:00

  • Association Between Smoking Status, Preoperative Exhaled Carbon Monoxide Levels, and Postoperative Surgical Site Infection in Patients Undergoing Elective Surgery.

    abstract:Importance:Cigarette smoking is a risk factor for many perioperative complications, including surgical site infection (SSI). The duration of abstinence from smoking required to reduce this risk is unknown. Objectives:To evaluate if abstinence from smoking on the day of surgery is associated with a decreased frequency ...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2016.5704

    authors: Nolan MB,Martin DP,Thompson R,Schroeder DR,Hanson AC,Warner DO

    更新日期:2017-05-01 00:00:00

  • Damage Control as a Strategy to Manage Postreperfusion Hemodynamic Instability and Coagulopathy in Liver Transplant.

    abstract:IMPORTANCE:Damage control (DC) with intra-abdominal packing and delayed reconstruction is an accepted strategy in trauma and acute care surgery but has not been evaluated in liver transplant. OBJECTIVE:To evaluate the incidence, effect on survival, and predictors of the need for DC using intra-abdominal packing and de...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2015.1853

    authors: DiNorcia J,Lee MK,Harlander-Locke MP,Xia V,Kaldas FM,Zarrinpar A,Farmer DG,Yersiz H,Hiatt JR,Busuttil RW,Agopian VG

    更新日期:2015-11-01 00:00:00

  • Association of Prehospital Plasma Transfusion With Survival in Trauma Patients With Hemorrhagic Shock When Transport Times Are Longer Than 20 Minutes: A Post Hoc Analysis of the PAMPer and COMBAT Clinical Trials.

    abstract:Importance:Both military and civilian clinical practice guidelines include early plasma transfusion to achieve a plasma to red cell ratio approaching 1:1 to 1:2. However, it was not known how early plasma should be given for optimal benefit. Two recent randomized clinical trials were published, with apparently contradi...

    journal_title:JAMA surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamasurg.2019.5085

    authors: Pusateri AE,Moore EE,Moore HB,Le TD,Guyette FX,Chapman MP,Sauaia A,Ghasabyan A,Chandler J,McVaney K,Brown JB,Daley BJ,Miller RS,Harbrecht BG,Claridge JA,Phelan HA,Witham WR,Putnam AT,Sperry JL

    更新日期:2020-02-01 00:00:00

  • Outcomes of Primary Chemotherapy for Borderline Resectable and Locally Advanced Pancreatic Ductal Adenocarcinoma.

    abstract:Importance:Chemotherapy is the recommended induction strategy in borderline resectable and locally advanced pancreatic ductal adenocarcinoma. However, the associated results on an intention-to-treat basis are poorly understood. Objective:To investigate pragmatically the treatment compliance, conversion to surgery, and...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2019.2277

    authors: Maggino L,Malleo G,Marchegiani G,Viviani E,Nessi C,Ciprani D,Esposito A,Landoni L,Casetti L,Tuveri M,Paiella S,Casciani F,Sereni E,Binco A,Bonamini D,Secchettin E,Auriemma A,Merz V,Simionato F,Zecchetto C,D'Onofri

    更新日期:2019-10-01 00:00:00

  • Association of Early Postdonation Renal Function With Subsequent Risk of End-Stage Renal Disease in Living Kidney Donors.

    abstract:Importance:Living kidney donation is associated with increased long-term risk of end-stage renal disease (ESRD). An early postdonation marker of ESRD risk could improve postdonation risk assessment and counseling for kidney donors and allow early intervention for donors at increased risk. Objective:To determine the as...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2019.5472

    authors: Massie AB,Holscher CM,Henderson ML,Fahmy LM,Thomas AG,Al Ammary F,Getsin SN,Snyder JJ,Lentine KL,Garg AX,Segev DL

    更新日期:2020-03-01 00:00:00

  • Development and Validation of a Comprehensive Model to Estimate Early Allograft Failure Among Patients Requiring Early Liver Retransplant.

    abstract:Importance:Expansion of donor acceptance criteria for liver transplant increased the risk for early allograft failure (EAF), and although EAF prediction is pivotal to optimize transplant outcomes, there is no consensus on specific EAF indicators or timing to evaluate EAF. Recently, the Liver Graft Assessment Following ...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2020.4095

    authors: Avolio AW,Franco A,Schlegel A,Lai Q,Meli S,Burra P,Patrono D,Ravaioli M,Bassi D,Ferla F,Pagano D,Violi P,Camagni S,Dondossola D,Montalti R,Alrawashdeh W,Vitale A,Teofili L,Spoletini G,Magistri P,Bongini M,Rossi

    更新日期:2020-12-01 00:00:00

  • Antibiotic Duration After Laparoscopic Appendectomy for Acute Complicated Appendicitis.

    abstract:IMPORTANCE:Optimal duration of antibiotic treatment to reduce infectious complications after an appendectomy for acute complicated appendicitis remains unclear. OBJECTIVE:To investigate the effect of antibiotic duration on infectious complications after laparoscopic appendectomy for acute complicated appendicitis. DE...

    journal_title:JAMA surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamasurg.2015.4236

    authors: van Rossem CC,Schreinemacher MH,van Geloven AA,Bemelman WA,Snapshot Appendicitis Collaborative Study Group.

    更新日期:2016-04-01 00:00:00

  • Association of Admission Laboratory Values and the Timing of Endoscopic Retrograde Cholangiopancreatography With Clinical Outcomes in Acute Cholangitis.

    abstract:Importance:Acute cholangitis (AC), particularly severe AC, has historically required urgent endoscopic decompression, although the timing of decompression is controversial. We previously identified 2 admission risk factors for adverse outcomes in AC: total bilirubin level greater than 10 mg/dL and white blood cell coun...

    journal_title:JAMA surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamasurg.2016.2329

    authors: Schwed AC,Boggs MM,Pham XD,Watanabe DM,Bermudez MC,Kaji AH,Kim DY,Plurad DS,Saltzman DJ,de Virgilio C

    更新日期:2016-11-01 00:00:00

  • Long-term Follow-up of Autologous Fat Transfer vs Conventional Breast Reconstruction and Association With Cancer Relapse in Patients With Breast Cancer.

    abstract:Importance:Autologous fat transfer (AFT or fat grafting) has become an invaluable tool for the correction of disfiguring deformities after breast cancer surgery. However, clinical and animal studies have shown conflicting results regarding its oncologic safety. Objective:To determine whether exposure to AFT vs convent...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2018.3744

    authors: Krastev T,van Turnhout A,Vriens E,Smits L,van der Hulst R

    更新日期:2019-01-01 00:00:00

  • Negative Pressure Wound Therapy for Closed Laparotomy Incisions in General and Colorectal Surgery: A Systematic Review and Meta-analysis.

    abstract:Importance:Surgical site infections (SSIs) are common after laparotomy wounds and are associated with a significant economic burden. The use of negative pressure wound therapy (NPWT) has recently been broadened to closed surgical incisions. Objective:To evaluate the association of prophylactic NPWT with SSI rates in c...

    journal_title:JAMA surgery

    pub_type: 杂志文章,meta分析

    doi:10.1001/jamasurg.2018.3467

    authors: Sahebally SM,McKevitt K,Stephens I,Fitzpatrick F,Deasy J,Burke JP,McNamara D

    更新日期:2018-11-01 00:00:00

  • Management of Severe Pancreatic Fistula After Pancreatoduodenectomy.

    abstract:Importance:Postoperative pancreatic fistula is a potentially life-threatening complication after pancreatoduodenectomy. Evidence for best management is lacking. Objective:To evaluate the clinical outcome of patients undergoing catheter drainage compared with relaparotomy as primary treatment for pancreatic fistula aft...

    journal_title:JAMA surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamasurg.2016.5708

    authors: Smits FJ,van Santvoort HC,Besselink MG,Batenburg MCT,Slooff RAE,Boerma D,Busch OR,Coene PPLO,van Dam RM,van Dijk DPJ,van Eijck CHJ,Festen S,van der Harst E,de Hingh IHJT,de Jong KP,Tol JAMG,Borel Rinkes IHM,Molenaar IQ

    更新日期:2017-06-01 00:00:00

  • Patient Preferences for Bariatric Surgery: Findings From a Survey Using Discrete Choice Experiment Methodology.

    abstract:Importance:Surgical options for weight loss vary considerably in risks and benefits, but the relative importance of procedure-associated characteristics in patient decision making is largely unknown. Objective:To identify patient preferences for risks, benefits, and other attributes of treatment options available to i...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2018.4375

    authors: Rozier MD,Ghaferi AA,Rose A,Simon NJ,Birkmeyer N,Prosser LA

    更新日期:2019-01-01 00:00:00

  • Recent developments in surgery: minimally invasive approaches for patients requiring pancreaticoduodenectomy.

    abstract::Over the past decade, minimally invasive surgery has been introduced as a means to allow manipulation of delicate tissues with outstanding visualization of the surgical field. The purpose of this article is to review the available literature regarding early postoperative outcomes and the technical challenges of minima...

    journal_title:JAMA surgery

    pub_type: 杂志文章,评审

    doi:10.1001/jamasurg.2013.366

    authors: Zenoni SA,Arnoletti JP,de la Fuente SG

    更新日期:2013-12-01 00:00:00

  • A Preoperative Scale for Determining Surgical Readmission Risk After Total Hip Replacement.

    abstract:IMPORTANCE:Total hip replacement is a commonly performed orthopedic procedure for the treatment of painful arthritis, osteonecrosis, or fracture. OBJECTIVE:To develop and verify a scale for predicting readmission rates for total hip replacement patients and allow for the development and implementation of readmission r...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2016.0020

    authors: Siracuse BL,Chamberlain RS

    更新日期:2016-08-01 00:00:00

  • Evidence for a Standardized Preadmission Showering Regimen to Achieve Maximal Antiseptic Skin Surface Concentrations of Chlorhexidine Gluconate, 4%, in Surgical Patients.

    abstract:IMPORTANCE:To reduce the amount of skin surface bacteria for patients undergoing elective surgery, selective health care facilities have instituted a preadmission antiseptic skin cleansing protocol using chlorhexidine gluconate. A Cochrane Collaborative review suggests that existing data do not justify preoperative ski...

    journal_title:JAMA surgery

    pub_type: 杂志文章,随机对照试验

    doi:10.1001/jamasurg.2015.2210

    authors: Edmiston CE Jr,Lee CJ,Krepel CJ,Spencer M,Leaper D,Brown KR,Lewis BD,Rossi PJ,Malinowski MJ,Seabrook GR

    更新日期:2015-11-01 00:00:00

  • Variation in Surgical Outcomes Across Networks of the Highest-Rated US Hospitals.

    abstract:Importance:Hospitals are rapidly consolidating into regional delivery networks. To our knowledge, whether these multihospital networks leverage their combined assets to improve quality and provide a uniform standard of care has not been explored. Objective:To evaluate the extent to which surgical outcomes varied acros...

    journal_title:JAMA surgery

    pub_type: 杂志文章,多中心研究

    doi:10.1001/jamasurg.2019.0090

    authors: Sheetz KH,Ibrahim AM,Nathan H,Dimick JB

    更新日期:2019-06-01 00:00:00

  • Mapping Disparities in Access to Safe, Timely, and Essential Surgical Care in Zambia.

    abstract:Importance:Surgical care is widely unavailable in developing countries; advocates recommend that countries evaluate and report on access to surgical care to improve availability and aid health planners in decision making. Objective:To analyze the infrastructure, capacity, and availability of surgical care in Zambia to...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2016.2303

    authors: Esquivel MM,Uribe-Leitz T,Makasa E,Lishimpi K,Mwaba P,Bowman K,Weiser TG

    更新日期:2016-11-01 00:00:00

  • Laparoscopic vs open ventral hernia repair in the era of obesity.

    abstract:IMPORTANCE:This study analyzes a role of laparoscopy in obese patients with ventral hernia. OBJECTIVE:To evaluate the outcomes of laparoscopic compared with open ventral hernia repair (VHR) in obese patients. DESIGN:Retrospective cohort analysis. SETTING:Nationwide hospital survey. PARTICIPANTS:Obese patients under...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2013.1395

    authors: Lee J,Mabardy A,Kermani R,Lopez M,Pecquex N,McCluney A

    更新日期:2013-08-01 00:00:00

  • Fixed-Distance Model for Balloon Placement During Fluoroscopy-Free Resuscitative Endovascular Balloon Occlusion of the Aorta in a Civilian Population.

    abstract:Importance:Resuscitative endovascular balloon occlusion of the aorta (REBOA) is an innovative procedure in the treatment of noncompressible truncal hemorrhage. However, readily available fluoroscopy remains a limiting factor in its widespread implementation. Several methods have been proposed to perform REBOA without f...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2016.4757

    authors: Pezy P,Flaris AN,Prat NJ,Cotton F,Lundberg PW,Caillot JL,David JS,Voiglio EJ

    更新日期:2017-04-01 00:00:00

  • Drug-Free Interventions to Reduce Pain or Opioid Consumption After Total Knee Arthroplasty: A Systematic Review and Meta-analysis.

    abstract:Importance:There is increased interest in nonpharmacological treatments to reduce pain after total knee arthroplasty. Yet, little consensus supports the effectiveness of these interventions. Objective:To systematically review and meta-analyze evidence of nonpharmacological interventions for postoperative pain manageme...

    journal_title:JAMA surgery

    pub_type: 杂志文章,meta分析,评审

    doi:10.1001/jamasurg.2017.2872

    authors: Tedesco D,Gori D,Desai KR,Asch S,Carroll IR,Curtin C,McDonald KM,Fantini MP,Hernandez-Boussard T

    更新日期:2017-10-18 00:00:00

  • Gender Disparity in Awards in General Surgery Residency Programs.

    abstract:Importance:Women are disproportionately underrecognized as award winners within medical societies. The presence of this disparity has not been investigated in training programs. Objective:To determine the presence of a gender disparity in award winners in general surgery residency programs. Design, Setting, and Parti...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2020.3518

    authors: Kuo LE,Lyu HG,Jarman MP,Melnitchouk N,Doherty GM,Smink DS,Cho NL

    更新日期:2020-09-02 00:00:00

  • Association of Video Completed by Audio in Laparoscopic Cholecystectomy With Improvements in Operative Reporting.

    abstract:Importance:All events that transpire during laparoscopic cholecystectomy (LC) cannot be adequately reproduced in the operative note. Video recording is already known to add important information regarding this operation. Objective:It is hypothesized that additional audio recordings can provide an even better procedura...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2020.0741

    authors: Eryigit Ö,van de Graaf FW,Nieuwenhuijs VB,Sosef MN,de Graaf EJR,Menon AG,Lange MM,Lange JF

    更新日期:2020-07-01 00:00:00

  • Evaluation of Intraoperative Near-Infrared Fluorescence Visualization of the Lung Tumor Margin With Indocyanine Green Inhalation.

    abstract:Importance:Identification of the tumor margin during surgery is important for precise minimal resection of lung tumors. Intravenous injection of indocyanine green (ICG) has several limitations when used for intraoperative visualization of lung cancer. Objectives:To describe a technique for intraoperative visualization...

    journal_title:JAMA surgery

    pub_type: 杂志文章

    doi:10.1001/jamasurg.2020.1314

    authors: Quan YH,Oh CH,Jung D,Lim JY,Choi BH,Rho J,Choi Y,Han KN,Kim BM,Kim C,Park JH,Kim HK

    更新日期:2020-06-24 00:00:00