Abstract:
:Hsp90 is essential for maintaining the activity of numerous signaling factors, and plays a key role in cellular signal transduction networks. 17-Allylamino-17-demethoxygeldanamycin (17-AAG) is an ansamycin antibiotic that binds to Hsp90 and inhibits its function. HaCaT human keratinocytes were used to investigate the cellular and molecular functions of Hsp90 in keratinocyte differentiation. Inhibition of Hsp90 by 17-AAG leads to downregulation of the differentiation markers cytokeratin 1 and cytokeratin 10 at the protein and mRNA levels.
journal_name
FEBS Open Biojournal_title
FEBS open bioauthors
Miyoshi S,Yamazaki S,Uchiumi A,Katagata Ydoi
10.1016/j.fob.2012.03.002subject
Has Abstractpub_date
2012-03-25 00:00:00pages
47-50issn
2211-5463pii
FOB14journal_volume
2pub_type
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