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Efficacy evaluation of the protein isolated from Peganum harmala seeds as an antioxidant in liver of rats.

Abstract：

OBJECTIVE:To evaluate the curative effect of the 132 KD protein isolated from the seeds of Peganum harmala (P. harmala) L. against carbon tetrachloride (CCl(4)) induced oxidative stress in rats. METHODS:Animals were post treated intraperitoneally with 132 KD isolated protein at doses of 4 and 8 mg/kg body weight and bovine serum albumin (BSA) (8 mg/kg body weight) as well as vitamin C (250 mg/kg body weight p.o.) for 7 d after they challenged with CCl(4) orally (1 mL/kg body weight) in olive oil (50%) for 2 d. RESULTS:The purified protein from seeds of P. harmala plant showed in vitro antioxidant activity with DPPH assay. Administration of CCl(4) induced induction in serum aminotransferases (AST, ALT), alkaline phosphatase (ALP), lipid profile parameters and liver malondialdehyde (MDA) and decrease in serum total protein, liver superoxide dismutase (SOD), catalase (CAT), and reduced glutathione (GSH) levels. 132 KD protein treatment of rats post CCl4 intoxication successfully alleviated the toxic effects of CCl(4). CONCLUSIONS:The isolated protein possessed strong antioxidant activity comparable to that of BSA (negative control) and vitamin C (positive control).

journal_name

Asian Pac J Trop Med

journal_title

Asian Pacific journal of tropical medicine

authors

Soliman AM,Abu-El-Zahab HS,Alswiai GA

doi

10.1016/S1995-7645(13)60058-9

subject

Has Abstract

pub_date

2013-04-13 00:00:00

pages

285-95

issue

4

eissn

1995-7645

issn

2352-4146

pii

S1995-7645(13)60058-9

journal_volume

6

pub_type

杂志文章

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