Abstract:
:A combinatorial library of 6 × 106 cyclic peptides was synthesized in the one bead-two compound format, with each bead displaying a unique cyclic peptide on its surface and a linear peptide encoding tag in its interior. Screening of the library against K-Ras identified compounds that bound K-Ras with submicromolar affinity and disrupted its interaction with effector proteins.
journal_name
Medchemcommjournal_title
MedChemCommauthors
Wu X,Upadhyaya P,Villalona-Calero MA,Briesewitz R,Pei Ddoi
10.1039/C2MD20329Dsubject
Has Abstractpub_date
2013-02-01 00:00:00pages
378-382issue
2eissn
2040-2503issn
2040-2511journal_volume
4pub_type
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