Inhibition of Ras-Effector Interaction by Cyclic Peptides.

Abstract:

:A combinatorial library of 6 × 106 cyclic peptides was synthesized in the one bead-two compound format, with each bead displaying a unique cyclic peptide on its surface and a linear peptide encoding tag in its interior. Screening of the library against K-Ras identified compounds that bound K-Ras with submicromolar affinity and disrupted its interaction with effector proteins.

journal_name

Medchemcomm

journal_title

MedChemComm

authors

Wu X,Upadhyaya P,Villalona-Calero MA,Briesewitz R,Pei D

doi

10.1039/C2MD20329D

subject

Has Abstract

pub_date

2013-02-01 00:00:00

pages

378-382

issue

2

eissn

2040-2503

issn

2040-2511

journal_volume

4

pub_type

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