Prospective comparison of (99m)Tc-GH SPECT/CT and (18)F-FDOPA PET/CT for detection of recurrent glioma: a pilot study.

Abstract:

OBJECTIVE:This study aimed to evaluate and compare the role of Tc-GH SPECT/CT and F-FDOPA PET/CT for diagnosing recurrence in patients with glioma. METHODS:Thirty patients with histopathologically proven glioma (glioblastoma multiforme, 14; grade III, 6; grade II, 8; and grade I, 2), who presented with clinical and/or imaging suspicion of recurrence were prospectively evaluated. They were primarily treated with surgery and radiotherapy with or without chemotherapy. Each patient underwent Tc-GH SPECT/CT and F-FDOPA PET/CT within a span of 15 days. Images were evaluated qualitatively and quantitatively by 2 experienced nuclear medicine physicians in consensus. Histopathology and/or clinical/imaging follow-up were used as reference standard. RESULTS:Based on reference standard, 22 patients were positive and 8 were negative for recurrence. Tc-GH SPECT/CT was positive for recurrence in 22 and negative in 8 patients. F-FDOPA PET/CT scan was positive for recurrence in 23 and negative in 7 patients. Sensitivity, specificity, and accuracy were 86.4%, 62.5%, and 80% for Tc-GH SPECT/CT and 100%, 87.5%, and 96% for F-FDOPA PET/CT, respectively. No significant difference was found between Tc-GH SPECT/CT and F-FDOPA PET/CT overall (P = 1.00), as well as for low-grade (P = 0.250) or high-grade tumors (P = 0.50). Significant correlation was noted between tumor-brain of Tc-GH with both tumor-striatum (r = 0.371; P = 0.044) and tumor-cerebellum ratio of F-FDOPA (r = 0.369; P = 0.045). CONCLUSIONS:For detection of recurrence in glioma patients, Tc-GH SPECT/CT is not inferior to F-FDOPA PET/CT and can be used as a low-cost alternative.

journal_name

Clin Nucl Med

authors

Karunanithi S,Bandopadhyaya GP,Sharma P,Kumar A,Singla S,Malhotra A,Gupta DK,Bal C

doi

10.1097/RLU.0b013e318279bcd8

subject

Has Abstract

pub_date

2014-02-01 00:00:00

pages

e121-8

issue

2

eissn

0363-9762

issn

1536-0229

journal_volume

39

pub_type

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