Retinal pigment epithelium cells can influence endothelial cell plasminogen activators.

abstract：:Substance P (SP)--like immunoreactivity has been localized to distinct retinal cell populations in the primate Macaca nemestrina by means of immunohistochemical techniques with a well-characterized monoclonal antiserum directed to SP. The specificity of the immunoreactive staining was established by absorption of the ...

journal_title：Investigative ophthalmology & visual science

authors： Brecha N,Hendrickson A,Florén I,Karten HJ

更新日期：1982-08-01 00:00:00

abstract：PURPOSE:To test whether eliprodil (SL 82.0715), a unique antagonist for the N-methyl-D-aspartate (NMDA) receptor, is protective in the glutamate-induced cytotoxicity model in cultured rat retinal ganglion cells (RGCs). METHODS:Two to four days after a fluorescent dye, Di-I, was injected near the superior colliculi, ne...

journal_title：Investigative ophthalmology & visual science

authors： Pang IH,Wexler EM,Nawy S,DeSantis L,Kapin MA

更新日期：1999-05-01 00:00:00

abstract：Purpose:Understanding the role of mitochondria in retinal ganglion cells (RGCs) is relevant to human disease as studies have shown mitochondrial abnormalities in primary open-angle glaucoma patients. This study seeks to determine the effects of the sigma-1 receptor (σ-1r) and its agonists on mitochondrial function in o...

journal_title：Investigative ophthalmology & visual science

authors： Ellis DZ,Li L,Park Y,He S,Mueller B,Yorio T

更新日期：2017-05-01 00:00:00

abstract：PURPOSE:The influences of diurnal rhythms involving a variety of ocular parameters are implicated in the development of myopia. The purpose of this study was to determine the expression of the melatonin receptor subtype proteins in chick ocular tissues and to examine the role of the circadian signaling molecule melaton...

journal_title：Investigative ophthalmology & visual science

authors： Rada JA,Wiechmann AF

更新日期：2006-01-01 00:00:00

abstract：:Chinese hamster ovarian (CHO) cells in culture were used to evaluate the relative antiproliferative potential of drugs. These agents have been used to improve the clinical response after glaucoma filtering surgery. The following drugs were evaluated: 5-fluorouracil (5-FU) as the benchmark, 5-fluorouridine (FUR), 5-flu...

journal_title：Investigative ophthalmology & visual science

authors： Senderoff RI,Weber PA,Smith DR,Sokoloski TD

更新日期：1990-12-01 00:00:00

abstract：Purpose:Ocular neovascularization (NV) is a pathologic process characterized by the proliferation and infiltration of various types of cells such as RPE, glial, and endothelial cells, which interact with proangiogenic factors and inflammatory cytokines. Endocan is known to be enriched in retinal endothelial tip cells u...

journal_title：Investigative ophthalmology & visual science

authors： Su T,Zhong Y,Demetriades AM,Shen J,Sui A,Yao Y,Gao Y,Zhu Y,Shen X,Xie B

更新日期：2018-02-01 00:00:00

abstract：Purpose:Suppression in amblyopia may be an unequal form of normal interocular suppression or a distinct pathophysiology. To explore this issue, we examined the orientation tuning and contrast dependence of continuous flash suppression (CFS) in adults with amblyopia and visually normal controls. Methods:Nine patients (...

journal_title：Investigative ophthalmology & visual science

authors： Gao TY,Ledgeway T,Lie AL,Anstice N,Black J,McGraw PV,Thompson B

更新日期：2018-11-01 00:00:00

abstract：PURPOSE:Imaging studies suggest that the choroidal vasculature may be altered in central serous chorioretinopathy. Little is known, however, about the regulation of ocular blood flow in patients with central serous chorioretinopathy (CSC). The hypothesis for the present study was that choroidal blood flow changes durin...

journal_title：Investigative ophthalmology & visual science

authors： Tittl M,Maar N,Polska E,Weigert G,Stur M,Schmetterer L

更新日期：2005-12-01 00:00:00

abstract：PURPOSE:To identify the chromosomal location of the gene causing snowflake vitreoretinal degeneration (SVD), an autosomal dominant retinal degeneration characterized by small yellow-white dots in the retina, fibrillar anomaly of the vitreous humor, and retinal detachment. METHODS:Clinical data were collected on 31 fam...

journal_title：Investigative ophthalmology & visual science

authors： Jiao X,Ritter R 3rd,Hejtmancik JF,Edwards AO

更新日期：2004-12-01 00:00:00

abstract：PURPOSE:Previous work from the authors' laboratory has shown that Hsp27 is specifically upregulated after retinal ischemic preconditioning (IPC), and this upregulation acts as a key cytoprotective factor in preventing retinal ischemic damage. The regulatory mechanisms involved in the upregulation of Hsp27 after IPC are...

journal_title：Investigative ophthalmology & visual science

authors： Whitlock NA,Agarwal N,Ma JX,Crosson CE

更新日期：2005-03-01 00:00:00

abstract：PURPOSE:We evaluated the relationship between cone photoreceptor packing density and outer nuclear layer (ONL) thickness within the central 15 degrees. METHODS:Individual differences for healthy subjects in cone packing density and ONL thickness were examined in 8 younger and 8 older subjects, mean age 27.2 versus 56....

journal_title：Investigative ophthalmology & visual science

authors： Chui TY,Song H,Clark CA,Papay JA,Burns SA,Elsner AE

更新日期：2012-06-14 00:00:00

abstract：PURPOSE:To evaluate a novel objective perimetry using multifocal chromatic pupil light reflex in normal participants and patients with photoreceptor dysfunction, and to relate this new technique with subjective dark-adapted chromatic Goldmann perimetry. METHODS:Thirty-two eyes of 17 retinitis pigmentosa (RP) or cone-r...

journal_title：Investigative ophthalmology & visual science

authors： Skaat A,Sher I,Kolker A,Elyasiv S,Rosenfeld E,Mhajna M,Melamed S,Belkin M,Rotenstreich Y

更新日期：2013-04-17 00:00:00

abstract：Purpose:To examine the early glial reactivity and neuron damage in response to short-term cerebrospinal fluid pressure (CSFp) reduction, as compared with intraocular pressure (IOP) elevation. Methods:The experiment included 54 male Sprague-Dawley rats with elevated translaminar cribrosa pressure difference (TLPD), def...

journal_title：Investigative ophthalmology & visual science

authors： Li XX,Zhang Z,Zeng HY,Wu S,Liu L,Zhang JX,Liu Q,Yang DY,Wang NL

更新日期：2018-07-02 00:00:00

abstract：PURPOSE:Doxorubicin chemomyectomy presently represents the only permanent, nonsurgical treatment for blepharospasm and hemifacial spasm. The major deterrent to an otherwise extremely effective treatment protocol is the development in patients of localized inflammation, discomfort, and skin injury over the injection sit...

journal_title：Investigative ophthalmology & visual science

authors： McLoon LK,Wirtschafter JD

更新日期：1999-10-01 00:00:00

abstract：:A method is presented for the rapid flow cytometric determination of epidermal growth factor (EGF) receptor densities on the surface of cultured ocular cells. The technique uses a biotinylated monoclonal antibody directed against the EGF receptor in conjunction with a streptavidin-bound fluorochrome and requires the s...

journal_title：Investigative ophthalmology & visual science

authors： Lopez JG,Chew SJ,Thompson HW,Malter JS,Insler MS,Beuerman RW

更新日期：1992-05-01 00:00:00

abstract：PURPOSE:Optical coherence tomography (OCT) can monitor for glaucoma by measuring dimensions of the optic nerve head (ONH) cup and disc. Multiple clinical studies have shown that different OCT devices yield different estimates of retinal dimensions. We developed phantoms mimicking ONH morphology as a new way to compare ...

journal_title：Investigative ophthalmology & visual science

authors： Agrawal A,Baxi J,Calhoun W,Chen CL,Ishikawa H,Schuman JS,Wollstein G,Hammer DX

更新日期：2016-07-01 00:00:00

abstract：PURPOSE:Microsaccades could indicate the place where our mind is unconsciously focusing, although our gaze is directed elsewhere. Many studies report the importance of microsaccades in visual scene perception, but none of them has addressed their relationship with the perception of a dynamic action and the prediction o...

journal_title：Investigative ophthalmology & visual science

authors： Piras A,Raffi M,Lanzoni IM,Persiani M,Squatrito S

更新日期：2015-07-01 00:00:00

abstract：Purpose:To investigate the chromatic characteristics and intensity-response function of light-induced reflex lacrimation and its correlation with the melanopsin-driven postillumination pupil response (PIPR). Methods:Eleven visually normal participants completed the experiment. Lacrimation was measured in one eye by pl...

journal_title：Investigative ophthalmology & visual science

authors： Lei S,Goltz HC,Chen X,Zivcevska M,Wong AM

更新日期：2017-03-01 00:00:00

abstract：PURPOSE:Keratoconus is a progressive disorder of the cornea that can lead to severe visual impairment or blindness. Although several genomic regions have been linked to rare familial forms of keratoconus, no genes have yet been definitively identified for common forms of the disease. METHODS:Two genome-wide associatio...

journal_title：Investigative ophthalmology & visual science

authors： Burdon KP,Macgregor S,Bykhovskaya Y,Javadiyan S,Li X,Laurie KJ,Muszynska D,Lindsay R,Lechner J,Haritunians T,Henders AK,Dash D,Siscovick D,Anand S,Aldave A,Coster DJ,Szczotka-Flynn L,Mills RA,Iyengar SK,Taylor KD,

更新日期：2011-10-31 00:00:00

abstract：PURPOSE:To assess RNA stability after death in a porcine model to simulate current human eye bank techniques. METHODS:Eye bank time interval data were collected from 191 donor specimens: death to refrigeration, enucleation, and tissue processing. A control porcine eye was enucleated, retina and RPE isolated, and speci...

journal_title：Investigative ophthalmology & visual science

authors： Malik KJ,Chen CD,Olsen TW

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:To investigate macular changes in acute retinopathy of prematurity (ROP). METHODS:Fifty-four premature infants with ROP and 20 controls underwent routine ROP screening with indirect ophthalmoscopy and imaging. A tabletop spectral domain optical coherence tomography (SD-OCT) scanner (Spectralis; Heidelberg Engi...

journal_title：Investigative ophthalmology & visual science

authors： Vinekar A,Avadhani K,Sivakumar M,Mahendradas P,Kurian M,Braganza S,Shetty R,Shetty BK

更新日期：2011-07-15 00:00:00

abstract：PURPOSE:To compare self-assessed driving habits and skills of licensed drivers with central visual loss who use bioptic telescopes to those of age-matched normally sighted drivers, and to examine the association between bioptic drivers' impressions of the quality of their driving and ratings by a "backseat" evaluator. ...

journal_title：Investigative ophthalmology & visual science

authors： Owsley C,McGwin G Jr,Elgin J,Wood JM

更新日期：2014-01-15 00:00:00

abstract：:Linear nonperforating incisions were made in the corneas of 2-week-old and 2-year-old rabbits. The resulting wounds were examined by light microscopy and transmission and scanning electron microscopy. A corneal incision of a 2-week-old rabbit produced a wide gaping wound caused by retraction of the cut stromal lamella...

journal_title：Investigative ophthalmology & visual science

authors： Lee RE,Davison PF,Cintron C

更新日期：1982-11-01 00:00:00

abstract：PURPOSE:To characterize the pharmacology of the carbachol-induced changes of phospholipase C (PLC) activity and intracellular calcium concentration ([Ca2+]i) in cultured human ciliary muscle cells. METHODS:Changes in PLC activity of cultured human ciliary muscle cells were determined by production of inositol phosphat...

journal_title：Investigative ophthalmology & visual science

authors： Matsumoto S,Yorio T,DeSantis L,Pang IH

更新日期：1994-09-01 00:00:00

abstract：PURPOSE:To investigate the responses of retinal ganglion cells (RGCs) to electrical stimulation, using electrodes comparable in size to those used in human studies investigating the feasibility of an electronic retinal prosthesis. METHODS:Rabbit retinas were stimulated in vitro with current pulses applied to the inner...

journal_title：Investigative ophthalmology & visual science

authors： Jensen RJ,Ziv OR,Rizzo JF 3rd

更新日期：2005-04-01 00:00:00

abstract：:The short-term fluctuation in regular grid threshold static fields is commonly determined from repeated observations of a number of threshold points. In this study we estimated the short-term fluctuation from a single determination of the field. Sixty-two eyes of 62 patients were tested, using three consecutive repeti...

journal_title：Investigative ophthalmology & visual science

authors： Schulzer M,Mills RP,Hopp RH,Lau W,Drance SM

更新日期：1990-04-01 00:00:00

abstract：PURPOSE:To determine the effect of treatment with latanoprost on the tissue inhibitors of metalloproteinase (TIMP)-1 and -2 in cultured human ciliary muscle (HCM) cells. METHODS:Confluent serum-starved HCM cells were exposed to increasing concentrations of latanoprost acid (LA, 1 nM to 10 micro M) for 6, 18, and 24 ho...

journal_title：Investigative ophthalmology & visual science

authors： Anthony TL,Lindsey JD,Weinreb RN

更新日期：2002-12-01 00:00:00

abstract：PURPOSE:The purposes of the present study were to assess the effect of a sympathetic inhibitory pharmacologic agent, timolol maleate, on the magnitude of nearwork-induced transient myopia (NITM) and its decay in different refractive groups for an extended near task duration and to determine the proportion of the young ...

journal_title：Investigative ophthalmology & visual science

authors： Vasudevan B,Ciuffreda KJ,Gilmartin B

更新日期：2009-01-01 00:00:00

abstract：PURPOSE:To compare a multisampling suprathreshold strategy with conventional suprathreshold and full-threshold strategies in detecting localized visual field defects and in quantifying the area of loss. METHODS:Probability theory was applied to examine various suprathreshold pass criteria (i.e., the number of stimuli ...

journal_title：Investigative ophthalmology & visual science

authors： Artes PH,Henson DB,Harper R,McLeod D

更新日期：2003-06-01 00:00:00

abstract：PURPOSE:Generate site-specific somatic mutations selectively in the retinal pigment epithelium (RPE) in mice. METHODS:A transgenic mouse line expressing the Cre recombinase under the control of the tyrosinase-related protein (TRP)-1 promoter was generated. The presence of Cre was determined by in situ hybridization, a...

journal_title：Investigative ophthalmology & visual science

authors： Mori M,Metzger D,Garnier JM,Chambon P,Mark M

更新日期：2002-05-01 00:00:00