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Do estrogen receptor alpha polymorphisms have any impact on the outcome in an ART program?

Abstract：

PURPOSE:To investigate two of the most studied estrogen receptor alpha polymorphisms (PvuII and XbaI) in combination, in order to evaluate their impact on an ART program outcome. METHODS:203 normally ovulating women who underwent IVF or ICSI treatment were genotyped for PvuII and XbaI polymorphisms in ESR1 intron 1 using Real-Time PCR. The relationship between the presence of polymorphic alleles and the ovulation induction parameters and outcome was examined. RESULTS:Women were grouped according to the number of polymorphic alleles they carried in two groups (0-2 versus 3-4 polymorphic alleles). The presence of 3 or more polymorphic alleles was associated with significantly lower E2 levels on the day of hCG administration and a significantly lower rate of good quality embryos. CONCLUSION:There is an association between ESR1 polymorphisms and some ART parameters such as the level of E2 on the day of hCG administration and the quality of the embryos. These results underline the importance of ESR1 as a candidate gene for the prediction of ovarian response to IVF/ICSI protocols. Future research work concerning several more genes is necessary for a better evaluation of patients before entering an IVF/ICSI program.

journal_name

J Assist Reprod Genet

journal_title

Journal of assisted reproduction and genetics

authors

Anagnostou E,Malamas F,Mavrogianni D,Dinopoulou V,Drakakis P,Kallianidis K,Loutradis D

doi

10.1007/s10815-013-9971-7

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

555-61

issue

4

eissn

1058-0468

issn

1573-7330

journal_volume

30

pub_type

杂志文章

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