Renal disease, epidermal necrosis, and epithelial cell antibodies.

Abstract:

OBJECTIVE:To describe the association between epithelial cell IgM, which has previously been associated with an increased incidence of loss of renal graft in children, with a novel cutaneous eruption and unexplained native renal disease. DESIGN:Observational study on children with epithelial cell antibody presenting with unexplained renal or skin disease. SETTING:General paediatric department and regional paediatric nephrology unit. PATIENTS:Six children (five girls, one boy), who presented to the unit in 1989-90. RESULTS:Three children, two of whom had a history of a hyperpigmented rash, presented with hypertension, proteinuria, and impaired renal function. Renal biopsy specimens from two of these children showed severe arteriolar endothelial cell swelling with arteriolar occlusion. These children fully recovered after treatment with antihypertensive drugs. The third child developed end stage renal failure and required dialysis. Three other children presented with an unusual cutaneous eruption but no evidence of renal disease. Histology of the skin lesions showed acute epidermal necrosis and features consistent with a viral infection. CONCLUSIONS:The aetiology and pathogenesis of the epithelial cell antibody are unknown. These cases indicate that it may have a role in native kidney disease and focal epidermal necrosis. Clinical and histological features suggest that the antibody may be associated with a viral infection.

journal_name

BMJ

authors

Deal JE,Groves RW,Harmer AW,Welsh KI,MacDonald DM,Rigden SP

doi

10.1136/bmj.303.6795.161

subject

Has Abstract

pub_date

1991-07-20 00:00:00

pages

161-3

issue

6795

eissn

0959-8138

issn

1756-1833

journal_volume

303

pub_type

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