The effect of extracorporeal shockwaves on cartilage end-plates in rabbits: a preliminary MRI and histopathological study.

Abstract:

OBJECTIVE:The aim of this study was to examine the changes in the lumbar intervertebral area after extracorporeal shockwave therapy (ESWT) at different energy levels in a rabbit model using magnetic resonance imaging (MRI) and histopathological evaluation. METHODS:The study included 30 male New Zealand white rabbits divided randomly into five groups: Groups A and C received 1,000 shockwave impulses at an intensity of 14 kV, Groups B and D received 1,000 impulses at 21 kV, and Group E was a sham group. Side effects such as subcutaneous and paravertebral soft-tissue injuries were evaluated using MRI one day after ESWT administration. Neovascularization, edema and fibroblast activity in the intervertebral area were evaluated histopathologically. RESULTS:No change was observed in any group on MRI. Histopathologically, Groups A and C showed no change, whereas Groups B and D showed edema, fibroblast activity and significant neovascularization at the intervertebral end-plate (p<0.05). CONCLUSION:Our findings indicate that ESWT caused dose-dependent changes in the intervertebral end-plate. This study constitutes a preliminary evaluation of shockwave therapy to the intervertebral area in an animal model. High-dose ESWT may stimulate angiogenesis at cartilage end-plates in rabbits.

authors

Ertürk C,Altay MA,Özardali İ,Altay N,Çeçe H,Işikan UE

doi

10.3944/aott.2012.2931

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

449-54

issue

6

eissn

1017-995X

issn

2589-1294

journal_volume

46

pub_type

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