Preventive evolutionary medicine of cancers.

Abstract:

:Evolutionary theory predicts that once an individual reaches an age of sufficiently low Darwinian fitness, (s)he will have reduced chances of keeping cancerous lesions in check. While we clearly need to better understand the emergence of precursor states and early malignancies as well as their mitigation by the microenvironment and tissue architecture, we argue that lifestyle changes and preventive therapies based in an evolutionary framework, applied to identified high-risk populations before incipient neoplasms become clinically detectable and chemoresistant lineages emerge, are currently the most reliable way to control or eliminate early tumours. Specifically, the relatively low levels of (epi)genetic heterogeneity characteristic of many if not most incipient lesions will mean a relatively limited set of possible adaptive traits and associated costs compared to more advanced cancers, and thus a more complete and predictable understanding of treatment options and outcomes. We propose a conceptual model for preventive treatments and discuss the many associated challenges.

journal_name

Evol Appl

authors

Hochberg ME,Thomas F,Assenat E,Hibner U

doi

10.1111/eva.12033

subject

Has Abstract

pub_date

2013-01-01 00:00:00

pages

134-43

issue

1

issn

1752-4571

journal_volume

6

pub_type

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