Abstract:
:Evolutionary theory predicts that once an individual reaches an age of sufficiently low Darwinian fitness, (s)he will have reduced chances of keeping cancerous lesions in check. While we clearly need to better understand the emergence of precursor states and early malignancies as well as their mitigation by the microenvironment and tissue architecture, we argue that lifestyle changes and preventive therapies based in an evolutionary framework, applied to identified high-risk populations before incipient neoplasms become clinically detectable and chemoresistant lineages emerge, are currently the most reliable way to control or eliminate early tumours. Specifically, the relatively low levels of (epi)genetic heterogeneity characteristic of many if not most incipient lesions will mean a relatively limited set of possible adaptive traits and associated costs compared to more advanced cancers, and thus a more complete and predictable understanding of treatment options and outcomes. We propose a conceptual model for preventive treatments and discuss the many associated challenges.
journal_name
Evol Appljournal_title
Evolutionary applicationsauthors
Hochberg ME,Thomas F,Assenat E,Hibner Udoi
10.1111/eva.12033subject
Has Abstractpub_date
2013-01-01 00:00:00pages
134-43issue
1issn
1752-4571journal_volume
6pub_type
杂志文章abstract::As we enter the sixth mass extinction, many species that are no longer self-sustaining in their natural habitat will require ex situ management. Zoos have finite resources for ex situ management, and there is a need for holistic conservation programs between the public and private sector. Ex situ populations of sable ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12976
更新日期:2020-04-27 00:00:00
abstract::Although microbes have been evolving resistance to antimicrobials for millennia, the spread of resistance in pathogen populations calls for the development of new drugs and treatment strategies. We propose that successful, long-term resistance management requires a better understanding of how resistance evolves in the...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12254
更新日期:2015-03-01 00:00:00
abstract::Once deployed uniformly in the field, genetically controlled plant resistance is often quickly overcome by pathogens, resulting in dramatic losses. Several strategies have been proposed to constrain the evolutionary potential of pathogens and thus increase resistance durability. These strategies can be classified into...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12681
更新日期:2018-09-17 00:00:00
abstract::The emergence and spread of antibiotic resistance in bacterial pathogens are a global crisis. Because many bacterial infections are caused by pathogens that reside in biofilms, we sought to investigate how biofilms influence the evolution of antibiotic resistance. We hypothesize that the inherent spatial structure of ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12728
更新日期:2018-12-22 00:00:00
abstract::With global climate change, rainfall is becoming more variable. Predicting the responses of species to changing rainfall levels is difficult because, for example in herbivorous species, these effects may be mediated indirectly through changes in host plant quality. Furthermore, species responses may result from a simu...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2011.00209.x
更新日期:2012-01-01 00:00:00
abstract::If the occurrence of cancer is the result of a random lottery among cells, then body mass, a surrogate for cells number, should predict cancer incidence. Despite some support in humans, this assertion does not hold over the range of different natural animal species where cancer incidence is known. Explaining the so-ca...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12025
更新日期:2013-01-01 00:00:00
abstract::All salmonid species investigated to date have been characterized with a male heterogametic sex-determination system. However, as these species do not share any Y-chromosome conserved synteny, there remains a debate on whether they share a common master sex-determining gene. In this study, we investigated the extent o...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12032
更新日期:2013-04-01 00:00:00
abstract::The aetiological agent of Chagas disease, Trypanosoma cruzi, is a key human pathogen afflicting most populations of Latin America. This vectorborne parasite is transmitted by haematophageous triatomines, whose control by large-scale insecticide spraying has been the main strategy to limit the impact of the disease for...
journal_title:Evolutionary applications
pub_type: 杂志文章,评审
doi:10.1111/eva.12582
更新日期:2017-12-25 00:00:00
abstract::The sterile insect technique (SIT) as an eco-friendly and reliable strategy has been used to control populations of insect pests of agricultural, veterinary and human health importance. Successful applications of SIT rely on the high-level ecological fitness of sterile males. A suitable and stable gut microbiome can c...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12698
更新日期:2018-10-09 00:00:00
abstract::One challenge of evolutionary ecology is to predict the rate and mechanisms of population adaptation to environmental variations. The variations in most life history traits are shaped both by individual genotypic and by environmental variation. Forest trees exhibit high levels of genetic diversity, large population si...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12143
更新日期:2014-04-01 00:00:00
abstract::Current natural populations face new interactions because of the re-emergence of ancient microbes and viruses. These risks come from the re-emergence of pathogens kept in laboratories or from pathogens that are retained in the permafrost, which become available upon thawing due to climate change. We here focus on the ...
journal_title:Evolutionary applications
pub_type: 杂志文章,评审
doi:10.1111/eva.12538
更新日期:2017-10-17 00:00:00
abstract::The evolutionary effects captive-bred individuals that can have on wild conspecifics are necessary considerations for stock enhancement programs, but breeding protocols are often developed without the knowledge of realized reproductive behavior. To help fill that gap, parentage was assigned to offspring produced by a ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2011.00234.x
更新日期:2012-06-01 00:00:00
abstract::Forest trees are an excellent resource from which to understand population differentiation and heterogeneous genome variation patterns due to the majority of forest trees being distributed widely and able to adapt to different climates and environments. Populus davidiana is among the most geographically widespread and...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.13046
更新日期:2020-07-15 00:00:00
abstract::Organisms are expected to respond to alterations in their survival by evolutionary changes in their life history traits. As agriculture and aquaculture have become increasingly intensive in the past decades, there has been growing interest in their evolutionary effects on the life histories of agri- and aquacultural p...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12488
更新日期:2017-06-21 00:00:00
abstract::Whilst adaptation and phenotypic plasticity might buffer species against habitat degradation associated with global climate change, few studies making such claims also possess the necessary and sufficient data to support them. Doing so requires demonstration of heritable variation in traits affecting fitness under new...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12363
更新日期:2016-02-18 00:00:00
abstract::While nonanadromous males (stream-resident and/or mature male parr) contribute to reproduction in anadromous salmonids, little is known about their impacts on key population genetic parameters. Here, we evaluated the contribution of Atlantic salmon mature male parr to the effective number of breeders (Nb) using both d...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12172
更新日期:2014-11-01 00:00:00
abstract::Restoration of lost species ranges to their native distribution is key for the survival of endangered species. However, reintroductions often fail and long-term genetic consequences are poorly understood. Alpine ibex (Capra ibex) are wild goats that recovered from <100 individuals to ~50,000 within a century by popula...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12490
更新日期:2017-10-27 00:00:00
abstract::Best practices in wildlife disease management require robust evolutionary ecological research (EER). This means not only basing management decisions on evolutionarily sound reasoning, but also conducting management in a way that actively contributes to the on-going development of that research. Because good management...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12171
更新日期:2014-08-01 00:00:00
abstract::Due to the mediating role of body size in determining fitness, the "bigger-is-better" hypothesis still pervades evolutionary ecology despite evidence that natural selection on phenotypic traits varies in time and space. For Pacific salmon (genus Oncorhynchus), most individual studies quantify selection across a narrow...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12957
更新日期:2020-04-09 00:00:00
abstract::Spatial and temporal trends and variation in life-history traits, including age and length at maturation, can be influenced by environmental and anthropogenic processes, including size-selective exploitation. Spawning adults in many wild Alaskan sockeye salmon populations have become shorter at a given age over the pa...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12123
更新日期:2014-02-01 00:00:00
abstract::Evidence of fishery-induced evolution has been accumulating rapidly from various avenues of investigation. Here we review the knowledge gained from experimental approaches. The strength of experiments is in their ability to disentangle genetic from environmental differences. Common garden experiments have provided dir...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2009.00079.x
更新日期:2009-08-01 00:00:00
abstract::Fisheries-induced evolution has been hypothesized to delay the recovery of collapsed fish stocks through effects on their productivity. The cod stock in the southern Gulf of St. Lawrence (SGSL) collapsed in the early 1990s and has shown no recovery since then, due mainly to high natural mortality of adult cod. Age and...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2010.00128.x
更新日期:2011-01-01 00:00:00
abstract::Currently, the effects of chronic, continuous low dose environmental irradiation on the mitochondrial genome of resident small mammals are unknown. Using the bank vole (Myodes glareolus) as a model system, we tested the hypothesis that approximately 50 generations of exposure to the Chernobyl environment has significa...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12475
更新日期:2017-06-22 00:00:00
abstract::Oceanic islands have reduced resources and natural enemies and potentially affect life history traits of arriving organisms. Among the most spectacular invasions in the Western hemisphere is that of the Africanized honeybee. We hypothesized that in the oceanic island Puerto Rico, Africanized bees will exhibit differen...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2012.00252.x
更新日期:2012-11-01 00:00:00
abstract::Changing climate and land-use practices have the potential to bring previously isolated populations of pest insects into new sympatry. This heightens the need to better understand how differing patterns of host-plant association, and unique endosymbionts, serve to promote genetic isolation or integration. We addressed...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.13079
更新日期:2020-09-12 00:00:00
abstract::The emergence and spread of antibiotic resistance is a crisis in health care today. Antibiotic resistance is often horizontally transferred to susceptible bacteria by means of multidrug resistance plasmids that may or may not persist in the absence of antibiotics. Because bacterial pathogens often grow as biofilms, th...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12480
更新日期:2017-05-08 00:00:00
abstract::Predictions about the consequences of a small population size on genetic and deleterious variation are fundamental to population genetics. As small populations are more affected by genetic drift, purifying selection acting against deleterious alleles is predicted to be less efficient, therefore increasing the risk of ...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12872
更新日期:2019-09-30 00:00:00
abstract::Eco-genetic individual-based models involve tracking the ecological dynamics of simulated individual organisms that are in part characterized by heritable parameters. We developed an eco-genetic individual-based model to explore ecological and evolutionary interactions of fish growth and maturation schedules. Our mode...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/j.1752-4571.2009.00088.x
更新日期:2009-08-01 00:00:00
abstract::In arid environments, the source of the malaria mosquito populations that re-establish soon after first rains remains a puzzle and alternative explanations have been proposed. Using genetic data, we evaluated whether the early rainy season (RS) population of Anopheles coluzzii is descended from the preceding late RS g...
journal_title:Evolutionary applications
pub_type: 杂志文章
doi:10.1111/eva.12486
更新日期:2017-05-26 00:00:00
abstract::Genetic variation is fundamental to population fitness and adaptation to environmental change. Human activities are driving declines in many wild populations and could have similar effects on genetic variation. Despite the importance of estimating such declines, no global estimate of the magnitude of ongoing genetic v...
journal_title:Evolutionary applications
pub_type: 杂志文章,评审
doi:10.1111/eva.12810
更新日期:2019-06-05 00:00:00