Abstract:
:Nitric oxide (NO) is a short-lived, pleiotropic molecule that affects numerous critical functions in the body. Presently, there are markedly conflicting findings in the literature regarding NO and its role in carcinogenesis and tumor progression. NO has been shown to have dichotomous effects on cellular proliferation, apoptosis, migration, invasion, angiogenesis and many other important processes in cancer biology. It has been shown to be both pro- and antitumorigenic, depending on the concentration and the tumor microenvironment in question. NO is generated by three isoforms of NO synthase (NOS) that are widely expressed and sometimes upregulated in human tumors. Due to its vast array of physiological functions, it presents a huge challenge to researchers to discover its true potential in cancer biology and consequently, its use in anticancer therapies. In this study, we review the current knowledge in this area, with an emphasis placed on NO modulation as an anticancer therapy, focusing on NO-donating drugs and NOS inhibitors.
journal_name
Carcinogenesisjournal_title
Carcinogenesisauthors
Burke AJ,Sullivan FJ,Giles FJ,Glynn SAdoi
10.1093/carcin/bgt034subject
Has Abstractpub_date
2013-03-01 00:00:00pages
503-12issue
3eissn
0143-3334issn
1460-2180pii
bgt034journal_volume
34pub_type
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