A family with Hoyeraal-Hreidarsson syndrome and four variants in two genes of the telomerase core complex.

abstract：:Two thirds of children with cancer never reach a specialist centre for treatment in South Africa. The majority of those who present have advanced disease. A campaign was undertaken to educate the public and the primary health workers on the Saint Siluan early warning signs of cancer in children. There was a statistica...

journal_title：Pediatric blood & cancer

authors： Poyiadjis S,Wainwright L,Naidu G,Mackinnon D,Poole J

更新日期：2011-02-01 00:00:00

abstract：:A 17-year-old girl with B-cell precursor acute lymphoblastic leukemia (BCP-ALL) with persistent minimal residual disease (MRD) who underwent standard chemotherapy was found to have a BCR-ABL1-like gene expression pattern. Genome sequencing revealed a JAK2 mutation not previously described in BCP-ALL and a potential th...

journal_title：Pediatric blood & cancer

authors： Mayfield JR,Czuchlewski DR,Gale JM,Matlawska-Wasowska K,Vasef MA,Nickl C,Pickett G,Ness SA,Winter SS

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:The male excess in childhood cancer incidence is well-established; however, the underlying biologic mechanisms remain unknown. Examining the association between male sex and childhood cancer by single year of age and tumor type may highlight important periods of risk such as variation in growth and hormonal ...

journal_title：Pediatric blood & cancer

authors： Williams LA,Richardson M,Marcotte EL,Poynter JN,Spector LG

更新日期：2019-06-01 00:00:00

abstract：:A 4-year-old male presented with rapid-onset cranial nerve palsy and ataxia. Brain magnetic resonance imaging (MRI) revealed a pontine mass lesion with discordant conventional and advanced imaging. A stereotactic core biopsy revealed glioblastoma with immunostaining suggestive of histone H3K27M and TP53 mutation, cons...

journal_title：Pediatric blood & cancer

authors： Tinkle CL,Orr BA,Lucas JT Jr,Klimo P,Patay Z,Baker SJ,Broniscer A,Qaddoumi I

更新日期：2017-08-01 00:00:00

abstract：:Neuroblastoma is the most common extracranial solid tumor of childhood, and the outcomes for children with high-risk and relapsed disease remain poor. However, new international strategies for risk stratification and for treatment based on novel tumor targets and including immunotherapy are being employed in attempts ...

journal_title：Pediatric blood & cancer

authors： Zage PE,Louis CU,Cohn SL

更新日期：2012-07-01 00:00:00

abstract：BACKGROUND:Despite the presence of reports on correlation between major congenital defects and cancer, very few studies have investigated the frequency of minor anomalies in childhood malignancy. The aim of this study was to determine the prevalence of minor anomalies in children with hematological malignancy. PROCEDU...

journal_title：Pediatric blood & cancer

authors： Citak FE,Citak EC,Akkaya E,Kosan B,Ezer U,Kurekci AE

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:Acinic cell carcinoma (AciCC) is rare in children; therefore, reaching a consensus on its management is challenging and radiotherapy is limited by concerns about long-term toxicity. The purpose of this study is to analyze the effectiveness and safety of surgery plus postoperative 125 I interstitial brachythe...

journal_title：Pediatric blood & cancer

authors： Li J,Zhang J,Lyu XM,Huang MW,Zheng L,Zhang JG

更新日期：2020-07-01 00:00:00

abstract：BACKGROUND:Ewing sarcoma (EWS) is rarely diagnosed as a second malignancy. We sought to describe a cohort of patients with secondary EWS and investigate if patient characteristics and survival differ between patients with secondary and primary EWS. PROCEDURE:Patients with EWS or peripheral primitive neuroectodermal tu...

journal_title：Pediatric blood & cancer

authors： Applebaum MA,Goldsby R,Neuhaus J,DuBois SG

更新日期：2013-04-01 00:00:00

abstract：:Malignant melanoma is rare in childhood and has never been reported to cause pancytopenia due to bone marrow metastases in a child. We report a 3-year-old boy with a large congenital melanocytic nevus who presented with bone pain and pancytopenia due to diffuse bone and bone marrow infiltration with metastatic melanom...

journal_title：Pediatric blood & cancer

authors： Spiller SE,Hawkins DS,Finn LS,Sze RW,Sybert V

更新日期：2005-07-01 00:00:00

abstract：:The Children's Oncology Group (COG) is a multi-institutional cooperative group dedicated to childhood cancer research that has helped to increase the survival of children with cancer through clinical trials. These clinical trials include a standardized regimen of imaging examinations performed prior to, during, and fo...

journal_title：Pediatric blood & cancer

authors： Meyer JS,Nadel HR,Marina N,Womer RB,Brown KL,Eary JF,Gorlick R,Grier HE,Randall RL,Lawlor ER,Lessnick SL,Schomberg PJ,Kailo MD

更新日期：2008-08-01 00:00:00

abstract：BACKGROUND:Thyroid dysfunction has been reported in up to 52% of patients 1.4 years after treatment with (131) I-Metaiodobenzylguanidine (MIBG) in children with neuroblastoma (NBL), despite the use of potassium-iodide (KI). Our aim was to investigate if the incidence and severity of thyroid damage increases in time. M...

journal_title：Pediatric blood & cancer

authors： Clement SC,van Eck-Smit BL,van Trotsenburg AS,Kremer LC,Tytgat GA,van Santen HM

更新日期：2013-11-01 00:00:00

abstract：BACKGROUND:The introduction of the United Kingdom Medical Research Council's 10th AML trial (MRC AML 10) protocol incorporating high-dose anthracycline therapy has improved outcome of children with acute myeloid leukemia (AML). In this study, we review the results of childhood AML therapy in a Singapore university hosp...

journal_title：Pediatric blood & cancer

authors： Tan RM,Quah TC,Aung L,Liang S,Kirk RC,Yeoh AE

更新日期：2007-03-01 00:00:00

abstract：:Chronic hypoxemia is a common manifestation among patients with sickle cell anemia (SCA) who develop chronic lung disease. We report the beneficial effect of hydroxyurea on chronic hypoxemia in three pediatric patients with SCA and recurrent episodes of acute chest syndrome (ACS). All three patients improved rapidly a...

journal_title：Pediatric blood & cancer

authors： Singh SA,Koumbourlis AC,Aygun B

更新日期：2008-06-01 00:00:00

abstract：BACKGROUND:Langerhans cell histiocytosis is a rare disease of unknown etiology. We wanted to assess the population-based incidence of LCH in a well-defined cohort of children. METHODS:We identified all children <15-years old treated with LCH during the 10 years period 1992-2001 at the Department of Pediatrics, Karolin...

journal_title：Pediatric blood & cancer

authors： Stålemark H,Laurencikas E,Karis J,Gavhed D,Fadeel B,Henter JI

更新日期：2008-07-01 00:00:00

abstract：:The BRAF V600E missense mutation is known to be present in a subset of central nervous system tumors. We report a patient with a BRAF V600E mutated pilomyxoid astrocytoma who failed multiple conventional chemotherapy regimens. Treatment with vemurafenib, a molecularly targeted therapy against the mutant BRAF V600E kin...

journal_title：Pediatric blood & cancer

authors： Skrypek M,Foreman N,Guillaume D,Moertel C

更新日期：2014-11-01 00:00:00

abstract：:We describe here the outcomes of reduced-toxicity alternate-donor stem cell transplant (SCT) with posttransplant cyclophosphamide (PTCy) for primary immunodeficiency disorders (PIDs) in eight children (haploidentical-seven and matched unrelated donor-one). The conditioning was with serotherapy (alemtuzumab-3/rabbit-an...

journal_title：Pediatric blood & cancer

authors： Rastogi N,Katewa S,Thakkar D,Kohli S,Nivargi S,Yadav SP

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Clear cell sarcoma of the kidney (CCSK) is known for its propensity to metastasize to bone, but it also spreads to other sites including the brain. This study was undertaken to describe the treatment and outcomes of patients with recurrent CCSK involving the brain. METHODS:A retrospective records review was...

journal_title：Pediatric blood & cancer

authors： Radulescu VC,Gerrard M,Moertel C,Grundy PE,Mathias L,Feusner J,Diller L,Dome JS

更新日期：2008-02-01 00:00:00

abstract：:Minimal residual disease (MRD) is an independent predictor of relapse risk in children with leukemia and is widely used for risk-adapted treatment. This article summarizes current evidence supporting the use of MRD, including clinical significance, current international clinical practice, impact statement, and recomme...

journal_title：Pediatric blood & cancer

authors： Athale UH,Gibson PJ,Bradley NM,Malkin DM,Hitzler J,POGO MRD Working Group.

更新日期：2016-06-01 00:00:00

abstract：:Under and overweight, usually secondary to energy imbalance, are common complications of childhood chronic disease. A simple energy balance paradigm has been helpful in understanding the etiology of underweight and overweight in chronic disease, including malignant disease, particularly when measurements of total ener...

journal_title：Pediatric blood & cancer

authors： Reilly JJ

更新日期：2008-02-01 00:00:00

abstract：BACKGROUND:Tumor cells frequently contaminate autologous stem cell products in a variety of malignancies, but their clinical significance remains controversial. We retrospectively monitored tumor contamination in stem cell harvests from patients with Ewing family of tumors (EFT) all harboring the specific translocation...

journal_title：Pediatric blood & cancer

authors： Yaniv I,Cohen IJ,Stein J,Zilberstein J,Liberzon E,Atlas O,Grunshpan A,Sverdlov Y,Ash S,Zaizov R,Avigad S

更新日期：2004-05-01 00:00:00

abstract：BACKGROUND:Physical fitness is an important determinant of quality of life (QOL) after hematopoietic stem cell transplantation. Cardiac function can influence exercise performance. The aim of this study was to assess these factors and their interrelationship. PROCEDURE:Children underwent cardiopulmonary exercise testi...

journal_title：Pediatric blood & cancer

authors： Vandekerckhove K,De Waele K,Minne A,Coomans I,De Groote K,Panzer J,Dhooge C,Bordon V,De Wolf D,Boone J

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Males have a higher incidence of medulloblastoma (MB) than females, but the effect of gender on survival is unclear. Studies have yielded conflicting results, possibly due to small sample sizes or differences in how researchers defined MB. We aimed to determine the effect of gender on survival in MB using a ...

journal_title：Pediatric blood & cancer

authors： Curran EK,Sainani KL,Le GM,Propp JM,Fisher PG

更新日期：2009-01-01 00:00:00

abstract：BACKGROUND:The optimal dose and schedule of mycophenolate mofetil (MMF) in pediatric allogeneic stem cell transplant recipients remains to be determined. We previously reported safety and pharmacokinetics of MMF at 900 mg/m2 q6h dosing. This study was conducted to investigate the efficacy of tacrolimus plus q8h MMF dos...

journal_title：Pediatric blood & cancer

authors： Militano O,Ozkaynak MF,Mehta B,van deVen C,Hamby C,Cairo MS

更新日期：2018-08-01 00:00:00

abstract：:Hepatoblastoma is a malignant pediatric liver tumor. The currently used diagnostic serum marker for hepatoblastoma, α-fetoprotein (AFP), is not always reliable in infants with hepatoblastoma, due to the physiologically elevated levels of AFP in this age group. In this report, we show that Delta-like 1 homolog (DLK1), ...

journal_title：Pediatric blood & cancer

authors： Falix FA,Aronson DC,Lamers WH,Hiralall JK,Seppen J

更新日期：2012-10-01 00:00:00

abstract：:The incompatibility causing fetal and neonatal alloimmune thrombocytopenia (FNAIT) results from a fetus inheriting a paternal human platelet antigen (HPA), which is different from the maternal HPA. We present a unique case of FNAIT in a pregnancy involving an oocyte recipient mother with Turner syndrome. This is the f...

journal_title：Pediatric blood & cancer

authors： Barg AA,Ifrah AD,Strauss T,Simchen MJ,Orvieto R,Rosenberg N,Kenet G

更新日期：2017-08-01 00:00:00

abstract：PURPOSE:To assess the safety of delayed high dose intravenous (i.v.) sodium thiosulfate (STS) in a case series of 12 children with malignant brain tumors who were treated with intraarterial (i.a.) carboplatin in conjunction with blood-brain-barrier disruption (BBBD). METHODS:Twelve children ages 17 months-12 years und...

journal_title：Pediatric blood & cancer

authors： Neuwelt EA,Gilmer-Knight K,Lacy C,Nicholson HS,Kraemer DF,Doolittle ND,Hornig GW,Muldoon LL

更新日期：2006-08-01 00:00:00

abstract：:Hemoglobin O-Arab [Beta 121 Glu → Lys] (Hb O-Arab) is a rare abnormal hemoglobin (Hb) whose clinical and hematological features have been described in adults but not in children. We report three children, 9, 12, and 36 months of age, with homozygous Hb O-Arab and assess the value of supplementary folic acid as treatme...

journal_title：Pediatric blood & cancer

authors： Dror S

更新日期：2013-03-01 00:00:00

abstract：BACKGROUND:Outcomes for patients with oncologic disease and/or after hematopoietic stem cell transplant (HSCT) requiring intensive care unit admission have improved, but indications for and outcomes after extracorporeal membrane oxygenation (ECMO) support in this population are poorly characterized. PROCEDURE:We analy...

journal_title：Pediatric blood & cancer

authors： Steppan DA,Coleman RD,Viamonte HK,Hanson SJ,Carroll MK,Klein OR,Cooke KR,Spinella PC,Steiner ME,Loftis LL,Bembea MM,Pediatric ECMO (PediECMO) subgroup of the Pediatric Acute Lung Injury and Sepsis Investigators (PALISI) Network and

更新日期：2020-10-01 00:00:00

abstract：BACKGROUND:Contemporary descriptions of classical Hodgkin lymphoma (cHL) are lacking from sub-Saharan Africa where human immunodeficiency virus (HIV) and Epstein-Barr virus (EBV) are prevalent. METHODS:We describe a prospective cHL cohort in Malawi enrolled from 2013 to 2015. Patients received standardized treatment a...

journal_title：Pediatric blood & cancer

authors： Westmoreland KD,Stanley CC,Montgomery ND,Kaimila B,Kasonkanji E,El-Mallawany NK,Wasswa P,Mtete I,Butia M,Itimu S,Chasela M,Mtunda M,Chikasema M,Makwakwa V,Kampani C,Dhungel BM,Sanders MK,Krysiak R,Tomoka T,Liomba NG

更新日期：2017-05-01 00:00:00

abstract：BACKGROUND:Follicular variant of papillary thyroid carcinoma (FVPTC) has been shown to be an intermediate entity between papillary (PTC) and follicular/Hurtle cell (FTC) thyroid carcinoma in adults. However, the tumor characteristics and prognosis of FVPTCs has not been studied in the pediatric population and is the fo...

journal_title：Pediatric blood & cancer

authors： Lerner J,Goldfarb M

更新日期：2015-11-01 00:00:00