Abstract:
:Inorganic polyphosphate is known to be present in the mammalian brain at micromolar concentrations. Here we show that polyphosphate may act as a gliotransmitter, mediating communication between astrocytes. It is released by astrocytes in a calcium-dependent manner and signals to neighbouring astrocytes through P2Y(1) purinergic receptors, activation of phospholipase C and release of calcium from the intracellular stores. In primary neuroglial cultures, application of polyP triggers release of endogenous polyphosphate from astrocytes while neurons take it up. In vivo, central actions of polyphosphate at the level of the brainstem include profound increases in key homeostatic physiological activities, such as breathing, central sympathetic outflow and the arterial blood pressure. Together, these results suggest a role for polyphosphate as a mediator of astroglial signal transmission in the mammalian brain.
journal_name
Nat Communjournal_title
Nature communicationsauthors
Holmström KM,Marina N,Baev AY,Wood NW,Gourine AV,Abramov AYdoi
10.1038/ncomms2364subject
Has Abstractpub_date
2013-01-01 00:00:00pages
1362issn
2041-1723pii
ncomms2364journal_volume
4pub_type
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