Pseudomonas fluorescens can induce and divert the human β-defensin-2 secretion in intestinal epithelial cells to enhance its virulence.

Abstract:

:The effect of intestinal molecules produced by the host on the virulence of Pseudomonas fluorescens is poorly documented. In the present work, we evaluated the secretion of human β-defensin-2 (hBD-2) by enterocytes after infection with P. fluorescens (a species previously suggested to be involved in inflammatory bowel disease) and investigated the effect of this host-defense peptide on the bacterial virulence. The results showed that P. fluorescens can induce hBD-2 production in Caco-2/TC7 cells via P38 and ERK MAPK-dependent pathways. Surprisingly, the exposure of P. fluorescens to low doses of the antimicrobial peptide was found to enhance its cytotoxic and proinflammatory effects suggesting a potential feedback mechanism in the dialog between bacteria and the host.

journal_name

Arch Microbiol

journal_title

Archives of microbiology

authors

Madi A,Alnabhani Z,Leneveu C,Mijouin L,Feuilloley M,Connil N

doi

10.1007/s00203-012-0865-3

subject

Has Abstract

pub_date

2013-03-01 00:00:00

pages

189-95

issue

3

eissn

0302-8933

issn

1432-072X

journal_volume

195

pub_type

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