Abstract：
:Accumulating data suggest that prenatal compromises leading to intrauterine growth restriction (IUGR) increase the risk for respiratory deficiencies after birth. In this respect, a growing body of epidemiological evidence in infants, children and adults indicates that small for gestational (SGA) birth weight can adversely affect lung function, thus questioning the widely accepted concept that IUGR accelerates lung maturation and improves outcome. Although the mechanisms responsible for the relationship between SGA and later lung dysfunction remain poorly documented, animal data indicate that intrauterine lung development can be adversely affected by factors associated with IUGR, namely reduced substrate supply, fetal hypoxemia and hypercortisolemia. Thus, it is suggested that fetal adaptations to intrauterine undernutrition result in permanent changes in lung structure, which in turn lead to chronic airflow obstruction. The purpose of this review is to describe and discuss the effects of IUGR on lung structure and function.
journal_name
Paediatr Respir Revjournal_title
Paediatric respiratory reviewsauthors
Briana DD,Malamitsi-Puchner Adoi
10.1016/j.prrv.2012.10.001subject
Has Abstractpub_date
2013-12-01 00:00:00pages
256-62issue
4eissn
1526-0542issn
1526-0550pii
S1526-0542(12)00087-5journal_volume
14pub_type
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
pub_type： 评论,杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
doi：10.1016/j.prrv.2004.11.004
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
doi：10.1016/j.prrv.2018.10.001
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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更新日期：2014-12-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
doi：10.1016/j.prrv.2005.09.011
更新日期：2005-12-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
doi：10.1016/j.prrv.2016.08.008
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
doi：10.1053/prrv.2001.0141
更新日期：2001-09-01 00:00:00
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
doi：10.1016/j.prrv.2008.10.001
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journal_title：Paediatric respiratory reviews
pub_type： 评论,杂志文章
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journal_title：Paediatric respiratory reviews
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journal_title：Paediatric respiratory reviews
pub_type： 杂志文章,评审
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journal_title：Paediatric respiratory reviews
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