The preparation of PLLA/calcium phosphate hybrid composite and its evaluation of biocompatibility.

Abstract:

:In tissue engineering, biodegradable polymer materials with both high biocompatibility and high strength are very important as scaffolds for long term use. Therefore, in this research, we tried to prepare the three types of poly(L-lactic acid) (PLLA)/calcium phosphate (CP) hybrid composite for a scaffold biomaterial. The effects of addition of different CP on both biocompatibility and mechanical properties were evaluated. CP powders and voids were three-dimensionally and uniformly distributed in the solid samples and porous composite samples. These compositions of CP and PLLA greatly improved the cellular adhesiveness, which increased as the volume fraction of CP in the composite increased. For the porous samples, cells migrated into the pores. This study demonstrated that a composite of PLLA and CP is an effective new scaffold material that results in better osteoconductivity, bone regeneration, and mineralization and has moderately high strength.

journal_name

Dent Mater J

journal_title

Dental materials journal

authors

Hamada Y,Fujitani W,Kawaguchi N,Daito K,Niido T,Uchinaka A,Mori S,Kojima Y,Manabe M,Nishida K,Arita K,Nakano T,Matsuura N

doi

10.4012/dmj.2012-117

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

1087-96

issue

6

eissn

0287-4547

issn

1881-1361

pii

DN/JST.JSTAGE/dmj/2012-117

journal_volume

31

pub_type

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