Abstract:
:Gene essentiality changes are crucial for organismal evolution. However, it is unclear how essentiality of orthologs varies across species. We investigated the underlying mechanism of gene essentiality changes between yeast and mouse based on the framework of network evolution and comparative genomic analysis. We found that yeast nonessential genes become essential in mouse when their network connections rapidly increase through engagement in protein complexes. The increased interactions allowed the previously nonessential genes to become members of vital pathways. By accounting for changes in gene essentiality, we firmly reestablished the centrality-lethality rule, which proposed the relationship of essential genes and network hubs. Furthermore, we discovered that the number of connections associated with essential and non-essential genes depends on whether they were essential in ancestral species. Our study describes for the first time how network evolution occurs to change gene essentiality.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Kim J,Kim I,Han SK,Bowie JU,Kim Sdoi
10.1038/srep00900subject
Has Abstractpub_date
2012-01-01 00:00:00pages
900issn
2045-2322journal_volume
2pub_type
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