Network rewiring is an important mechanism of gene essentiality change.

Abstract:

:Gene essentiality changes are crucial for organismal evolution. However, it is unclear how essentiality of orthologs varies across species. We investigated the underlying mechanism of gene essentiality changes between yeast and mouse based on the framework of network evolution and comparative genomic analysis. We found that yeast nonessential genes become essential in mouse when their network connections rapidly increase through engagement in protein complexes. The increased interactions allowed the previously nonessential genes to become members of vital pathways. By accounting for changes in gene essentiality, we firmly reestablished the centrality-lethality rule, which proposed the relationship of essential genes and network hubs. Furthermore, we discovered that the number of connections associated with essential and non-essential genes depends on whether they were essential in ancestral species. Our study describes for the first time how network evolution occurs to change gene essentiality.

journal_name

Sci Rep

journal_title

Scientific reports

authors

Kim J,Kim I,Han SK,Bowie JU,Kim S

doi

10.1038/srep00900

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

900

issn

2045-2322

journal_volume

2

pub_type

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