Abstract:
:Skeletal muscle injuries are among the most common and frequently disabling injuries sustained by athletes. Repair of injured skeletal muscle is an area that continues to present a challenge for sports medicine clinicians and researchers due, in part, to complete muscle recovery being compromised by development of fibrosis leading to loss of function and susceptibility to re-injury. Injured skeletal muscle goes through a series of coordinated and interrelated phases of healing including degeneration, inflammation, regeneration and fibrosis. Muscle regeneration initiated shortly after injury can be limited by fibrosis which affects the degree of recovery and predisposes the muscle to reinjury. It has been demonstrated in animal studies that antifibrotic agents that inactivate transforming growth factor (TGF)-β1 have been effective at decreasing scar tissue formation. Several studies have also shown that vascular endothelial growth factor (VEGF) can increase the efficiency of skeletal muscle repair by increasing angiogenesis and, at the same time, reducing the accumulation of fibrosis. We have isolated and thoroughly characterised a population of skeletal muscle-derived stem cells (MDSCs) that enhance repair of damaged skeletal muscle fibres by directly differentiating into myofibres and secreting paracrine factors that promote tissue repair. Indeed, we have found that MDSCs transplanted into skeletal and cardiac muscles have been successful at repair probably because of their ability to secrete VEGF that works in a paracrine fashion. The application of these techniques to the study of sport-related muscle injuries awaits investigation. Other useful strategies to enhance skeletal muscle repair through increased vascularisation may include gene therapy, exercise, neuromuscular electrical stimulation and, potentially, massage therapy. Based on recent studies showing an accelerated recovery of muscle function from intense eccentric exercise through massage-based therapies, we believe that this treatment modality offers a practical and non-invasive form of therapy for skeletal muscle injuries. However, the biological mechanism(s) behind the beneficial effect of massage are still unclear and require further investigation using animal models and potentially randomised, human clinical studies.
journal_name
Br J Sports Medjournal_title
British journal of sports medicineauthors
Best TM,Gharaibeh B,Huard Jdoi
10.1136/bjsports-2012-091685subject
Has Abstractpub_date
2013-06-01 00:00:00pages
556-60issue
9eissn
0306-3674issn
1473-0480pii
bjsports-2012-091685journal_volume
47pub_type
杂志文章,评审abstract:OBJECTIVE:To determine the plasma glucose levels in non-diabetic patients with rotator cuff tear. DESIGN:Frequency-matched case-control study. SETTING:University Teaching Hospital. PARTICIPANTS:The study included 194 subjects who were operated on at our institution. Group 1 included 97 consecutive patients (36 men a...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2008.049320
更新日期:2009-04-01 00:00:00
abstract:OBJECTIVES:To study the long term effect of tibial shaft fractures treated by immobilisation in a long leg cast on the calf muscle bulk. METHODS:Computed tomography scans were performed at fixed points on the lower legs of 23 non-professional athletes who sustained closed tibial fractures 16 years previously. Length o...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2005.020743
更新日期:2006-06-01 00:00:00
abstract:OBJECTIVE:To determine prospectively gait-related intrinsic risk factors for patellofemoral pain (PFP) in a population of novice recreational runners. DESIGN:Prospective cohort study. PARTICIPANTS:102 novice recreational runners (89 women) with no history of knee or lower leg complaints. INTERVENTIONS:The standing f...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2008.046649
更新日期:2008-06-01 00:00:00
abstract::Thirty one amateur skiers with 33 knees which had had a symptomatic chronic rupture of the anterior cruciate ligament (ACL) treated with the Lemaire operation were reviewed retrospectively at an average of 4.5 years. Of the patients 23 were women. The operation failed to control symptoms in 17 out of the 33 knees. How...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.28.1.31
更新日期:1994-03-01 00:00:00
abstract::Anabolic androgenic steroids (AAS) are used illicitly at high doses by bodybuilders. The misuse of these drugs is associated with serious adverse effects to the liver, including cellular adenomas and adenocarcinomas. We report two very different cases of adult male bodybuilders who developed hepatocellular adenomas fo...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsm.2004.013599
更新日期:2005-05-01 00:00:00
abstract:OBJECTIVES:To compare versions 8 and 10 of the Orchard Sports Injury Classification System (OSICS) to determine whether the revised version of OSICS has improved its use in a sports medicine setting, and to assess the inter-rater reliability of OSICS-10. METHODS:Injury surveillance data, gathered over a 2 year period ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2008.051979
更新日期:2009-07-01 00:00:00
abstract:INTRODUCTION:A conservative method of treating four delayed union stress fractures of the anterior mid-tibia is described, with an illustrative case history. METHODS:Once diagnosed each of the patients was treated in a pneumatic lower leg brace with modified rest. The mean (range) age of the patients was 28 (24-32) ye...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.35.1.74
更新日期:2001-02-01 00:00:00
abstract::Athletes such as skaters and skiers inhale large volumes of cold air during exercise and shift from nasal to mouth breathing. Endurance athletes, like cross-country skiers, perform at 80% or more of their maximal oxygen consumption and have minute ventilations in excess of 100 l/min. Cold air is always dry, and endura...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2011-090822
更新日期:2012-05-01 00:00:00
abstract:OBJECTIVE:To establish the relation between handball playing, passive hip range of motion (ROM), and the development of radiological hip osteoarthritis (OA) in former elite handball players. Two related issues are addressed: (a) the relation between long term elite handball playing and the incidence of hip OA; (b) the ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2005.019026
更新日期:2006-01-01 00:00:00
abstract:OBJECTIVE:The perception of Nigerian athletes of the use of mouth guards to prevent the stresses of sports injuries was examined using psychological, sociological, and physical stress variables. METHODS:The descriptive survey research design was used in this study. Participants (n = 333) were selected using the purpos...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.004838
更新日期:2004-12-01 00:00:00
abstract:BACKGROUND AND AIM:Bowling-side quadratus lumborum (QL) asymmetries have been previously reported on the dominant side in junior cricket fast bowlers using MRI. The aim of this study was to investigate QL asymmetry when measuring with two different methods; first using a small number of images with clear muscle borders...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2010.077453
更新日期:2012-03-01 00:00:00
abstract:OBJECTIVES:To assess the results of inferior capsular shift for multidirectional instability of the shoulder in athletes. METHODS:Multidirectional instability was surgically corrected in 53 shoulders in 47 athletes who engaged in contact sports. A history of major trauma was found in eight patients, the others having ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.36.4.290
更新日期:2002-08-01 00:00:00
abstract:OBJECTIVES:To investigate the validity and reliability of surface electromyography (EMG) as a new non-invasive determinant of the metabolic response to incremental exercise in elite cyclists. The relation between EMG activity and other more conventional methods for analysing the aerobic-anaerobic transition such as blo...
journal_title:British journal of sports medicine
pub_type: 临床试验,杂志文章
doi:10.1136/bjsm.33.3.178
更新日期:1999-06-01 00:00:00
abstract:AIMS:(1) To investigate whether a daily acute:chronic workload ratio informs injury risk in Australian football players; (2) to identify which combination of workload variable, acute and chronic time window best explains injury likelihood. METHODS:Workload and injury data were collected from 53 athletes over 2 seasons...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2016-096309
更新日期:2017-08-01 00:00:00
abstract:BACKGROUND:Illness accounts for a significant proportion of consultations with a team physician travelling with elite athletes. OBJECTIVE:To determine if international travel increases the incidence of illness in rugby union players participating in a 16-week tournament. SETTING:2010 Super 14 Rugby Union tournament. ...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2012-091395
更新日期:2012-09-01 00:00:00
abstract:OBJECTIVE:To evaluate a potential reduction in injury related healthcare costs when using the '11+ Kids' injury prevention programme compared with a usual warmup in children's football. METHODS:This cost effectiveness analysis was based on data collected in a cluster randomised controlled trial over one season from fo...
journal_title:British journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/bjsports-2018-099395
更新日期:2019-03-01 00:00:00
abstract:OBJECTIVE:To examine differences in ad libitum fluid intake, comparing a 6% carbohydrate/electrolyte drink (CHO-E) and water, and associated differences in core temperature and other selected physiological and perceptual responses in adolescent athletes during tennis training in the heat. METHODS:Fourteen healthy, fit...
journal_title:British journal of sports medicine
pub_type: 杂志文章,随机对照试验
doi:10.1136/bjsm.2005.023333
更新日期:2006-05-01 00:00:00
abstract:BACKGROUND:Reduced flexibility has been documented in athletes with lower limb injury, however, stretching has limited evidence of effectiveness in preventing injury or reducing the risk of recurrence. In contrast, it has been proposed that eccentric training can improve strength and reduce the risk of injury, and faci...
journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2011-090835
更新日期:2012-09-01 00:00:00
abstract::Posterior dislocation of the shoulder is an uncommon injury, accounting for between 2% and 4% of all shoulder dislocations. It occurs most frequently in patients following convulsions or direct anterior force to the shoulder. It is a particularly uncommon injury in sport. This paper reports an unusual case of bilateal...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.31.1.74
更新日期:1997-03-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2008.053645
更新日期:2009-08-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2014-093557
更新日期:2015-03-01 00:00:00
abstract::The purpose of this study was to formulate a simplistic method of assessing human structural dysplasia and to validate a classification system that would objectively categorize the type and extent of such dysplasia through the use of indices. Anthropometric measurements were taken from a sample of 222 male college stu...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.18.1.22
更新日期:1984-03-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.009951
更新日期:2005-03-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章,多中心研究
doi:10.1136/bjsports-2012-091357
更新日期:2014-10-01 00:00:00
abstract::The Concussion Recognition Tool 5 (CRT5) is the most recent revision of the Pocket Sport Concussion Assessment Tool 2 that was initially introduced by the Concussion in Sport Group in 2005. The CRT5 is designed to assist non-medically trained individuals to recognise the signs and symptoms of possible sport-related co...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2017-097508
更新日期:2017-06-01 00:00:00
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journal_title:British journal of sports medicine
pub_type: 杂志文章,评审
doi:10.1136/bjsports-2013-092950
更新日期:2013-12-01 00:00:00
abstract::This study was carried out to determine the rate and types of injuries experienced by boardsailors. Results derive from: (a) a review of hospital medical records for water sports injuries, and (b) a questionnaire-interview of 73 athletes windsurfing on waters in the Galveston area during a hurricane and in moderate an...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.22.3.95
更新日期:1988-09-01 00:00:00
abstract:BACKGROUND:Salbutamol has been shown to mediate anabolic effects after intravenous administration. However, the mechanism responsible for the anabolic actions of salbutamol remains unknown. AIM:To investigate the potential mechanism by which salbutamol mediates anabolic effects in vitro. METHODS:The potential androge...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2007.035162
更新日期:2007-12-01 00:00:00
abstract::A professional rugby league player sustained a left eyebrow laceration during a match which immediately started to bleed. Within seconds he was taken to the sideline and had the laceration closed with six staples by the team doctor. Bleeding was arrested and he returned to play, taking the ball within 80 s of sufferin...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsm.2003.005470
更新日期:2004-08-01 00:00:00
abstract:BACKGROUND:Course setting has often been discussed as a potential preventative measure in the World Cup ski-racing community. However, there is limited understanding of how it is related to injury risk. OBJECTIVE:This study was undertaken to investigate the effect of increased horizontal gate distance on energy-relate...
journal_title:British journal of sports medicine
pub_type: 杂志文章
doi:10.1136/bjsports-2012-091425
更新日期:2012-12-01 00:00:00