Proteomic analysis of human blastocoel fluid and blastocyst cells.

abstract：:Bisphosphonate-related osteonecrosis of the jaws (BRONJ) is a severe adverse reaction, which results in progressive bone destruction in the maxillofacial region of patients. To date, the pathological mechanisms remain largely unclear. Recently, we found that BRONJ patient had significantly deep periodontal pockets and...

journal_title：Stem cells and development

authors： Li M,Yu Y,Shi Y,Zhou Y,Zhang W,Hua H,Ge J,Zhang Z,Ye D,Yang C,Wang S

更新日期：2020-02-01 00:00:00

abstract：:Placental abnormalities can cause Pregnancy-Associated Disorders, including preeclampsia, intrauterine growth restriction, and placental insufficiency, resulting in complications for both the mother and fetus. Trophoblast cells within the labyrinthine layer of the placenta facilitate the exchange of nutrients, gases, ...

journal_title：Stem cells and development

authors： Waker CA,Albers RE,Pye RL,Doliboa SR,Wyatt CN,Brown TL,Mayes DA

更新日期：2017-06-01 00:00:00

abstract：:Small molecules (SM) can greatly enhance the efficiency of induced pluripotent stem (iPS) cell generation, but the mechanisms by which they act have not been fully explored. We show here that an SM cocktail (NaB, PD03259, and SB431542) significantly promotes iPS cell generation from human fibroblasts, and NaB is more ...

journal_title：Stem cells and development

authors： Zhang Z,Wu WS

更新日期：2013-08-15 00:00:00

abstract：:Stem cell therapy is a promising therapeutic strategy for treating myocardial infarction (MI). However, it is necessary to identify ideal adult stem cells for transplantation and explore mechanisms of the transplanted cells in improving cardiac functions after MI. In this study, a population of embryonic-like stem cel...

journal_title：Stem cells and development

authors： Wu JH,Wang HJ,Tan YZ,Li ZH

更新日期：2012-05-20 00:00:00

abstract：:Human umbilical cord blood (CB) has been used successfully in stem cell transplantation. A subpopulation of CD34(+) cells expresses chemokine receptor CXCR4 which is critical for bone marrow engraftment in human hematopoietic stem cells. Here, we demonstrate the effect of short-term culture on CXCR4 expression on umbi...

journal_title：Stem cells and development

authors： Ohno N,Kajiume T,Sera Y,Sato T,Kobayashi M

更新日期：2009-10-01 00:00:00

abstract：:Immunodeficient mice transplanted with human hematopoietic stem cells (HSCs) have been referred to as "Human Immune System" (HIS) mice and are a translational platform for studying human immune responses in vivo. Human HSC sources used in generating HIS mice include fetal liver (FL), umbilical cord blood (CB), and adu...

journal_title：Stem cells and development

authors： Walker JA,Vuyyuru R,Manser T,Alugupalli KR

更新日期：2017-12-01 00:00:00

abstract：:There have been reports of marrow cells converting into pulmonary epithelial cells after marrow transplantation in irradiated mice. We evaluated the impact of whole bone marrow (WBM) infusion in mice, with or without total body irradiation (TBI), treated with saline or monocrotaline (MCT), which induces pulmonary hype...

journal_title：Stem cells and development

authors： Aliotta JM,Keaney PJ,Warburton RR,DelTatto M,Dooner MS,Passero MA,Quesenberry PJ,Klinger JR

更新日期：2009-06-01 00:00:00

abstract：:Accumulating evidence suggests that the delivery of human adipose tissue-derived stromal cells (hASCs) has great potential as regenerative therapy. This was performed to develop a method for expanding hASCs by reducing the amount of serum required. We demonstrate that hASCs were able to expand efficiently in media con...

journal_title：Stem cells and development

authors： Iwashima S,Ozaki T,Maruyama S,Saka Y,Kobori M,Omae K,Yamaguchi H,Niimi T,Toriyama K,Kamei Y,Torii S,Murohara T,Yuzawa Y,Kitagawa Y,Matsuo S

更新日期：2009-05-01 00:00:00

abstract：:The major reservoir of human multipotent mesenchymal stem/stromal cells (MSCs) is the bone marrow (BM) with the capability to control hematopoietic stem cell development. The regenerative potential of MSCs is associated with enhanced endogenous repair and healing mechanisms that modulate inflammatory responses. Our pr...

journal_title：Stem cells and development

authors： Bacskai I,Mázló A,Kis-Tóth K,Szabó A,Panyi G,Sarkadi B,Apáti Á,Rajnavölgyi É

更新日期：2015-08-01 00:00:00

abstract：:Nonpluripotent neural progenitor cells (NPCs) derived from the human fetal central nervous system were found to express a number of messenger RNA (mRNA) species associated with pluripotency, such as NANOG, REX1, and OCT4. The expression was restricted to small subpopulations of NPCs. In contrast to pluripotent stem ce...

journal_title：Stem cells and development

authors： Vincent PH,Benedikz E,Uhlén P,Hovatta O,Sundström E

更新日期：2017-06-15 00:00:00

abstract：:Cardiac stem/progenitors are being used in the clinic to treat patients with a range of cardiac pathologies. However, improvements in heart function following treatment have been reported to be variable, with some showing no response. This discrepancy in response remains unresolved. Mesenchymal stem cells (MSCs) have ...

journal_title：Stem cells and development

authors： Oldershaw R,Owens WA,Sutherland R,Linney M,Liddle R,Magana L,Lash GE,Gill JH,Richardson G,Meeson A

更新日期：2019-05-01 00:00:00

abstract：:Stem cell-based therapy is a promising treatment for neurodegenerative diseases. In our laboratory, a novel protocol has been developed to induce bone marrow-derived mesenchymal stem cells (MSC) into neurotrophic factors- secreting cells (NTF-SC), thus combining stem cell-based therapy with the NTF-based neuroprotecti...

journal_title：Stem cells and development

authors： Sadan O,Bahat-Stromza M,Barhum Y,Levy YS,Pisnevsky A,Peretz H,Ilan AB,Bulvik S,Shemesh N,Krepel D,Cohen Y,Melamed E,Offen D

更新日期：2009-10-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) have attracted much attention as potential platforms for transgene delivery and cell-based therapy for human disease. MSCs have the capability to self-renew and retain multipotency after extensive expansion in vitro, making them attractive targets for ex vivo modification and autologous t...

journal_title：Stem cells and development

authors： Ricks DM,Kutner R,Zhang XY,Welsh DA,Reiser J

更新日期：2008-06-01 00:00:00

abstract：:Lifelong neurogenesis in the mouse olfactory epithelium (OE) is regulated by the response of stem/progenitor cells to local signals, but embryonic and adult OE progenitors appear to be quite different--with potentially different mechanisms of regulation. A recently identified progenitor unique to embryonic OE--the nes...

journal_title：Stem cells and development

authors： Murdoch B,Roskams AJ

更新日期：2013-02-15 00:00:00

abstract：:Stem cell factor (SCF) stimulation of the receptor tyrosine kinase c-kit has effects on the proliferation, differentiation, and apoptotic regulation of hematopoietic progenitor cell populations. Rat bone marrow myelomonocytic stem cells (MSC) isolated in vitro by wheat germ agglutinin culture exclusively undergo self-...

journal_title：Stem cells and development

authors： Lucas T,Pratscher B,Fink D,Wolschek M,Samorapoompichit P,Schöfer C,Pehamberger H,Müller M,Sorensen P,Jansen B

更新日期：2005-10-01 00:00:00

abstract：:The design of reliable biocompatible and biodegradable scaffolds remains one of the most important challenges for tissue engineering. In fact, properly designed scaffolds must display an adequate and interconnected porosity to facilitate cell spreading and colonization of the inner layers, and must release physical si...

journal_title：Stem cells and development

authors： Ciocci M,Mochi F,Carotenuto F,Di Giovanni E,Prosposito P,Francini R,De Matteis F,Reshetov I,Casalboni M,Melino S,Di Nardo P

更新日期：2017-10-01 00:00:00

abstract：:Retinoic acid (RA) induces mouse F9 cells to form primitive endoderm (PrE) and increased levels of reactive oxygen species (ROS) accompany differentiation. ROS are obligatory for differentiation and while H2O2 alone induces PrE, antioxidants attenuate the response to RA. Evidence shows that ROS can modulate the Wnt/β-...

journal_title：Stem cells and development

authors： Sandieson L,Hwang JT,Kelly GM

更新日期：2014-05-15 00:00:00

abstract：:Hematopoietic stem cells (HSCs) possess a distinct ability to perpetuate through self-renewal and to generate progeny that differentiate into mature cells of myeloid and lymphoid lineages. A better understanding of the molecular mechanisms by which HSCs replicate and differentiate from the perspective of developing ne...

journal_title：Stem cells and development

authors： Sharma S,Gurudutta GU,Satija NK,Pati S,Afrin F,Gupta P,Verma YK,Singh VK,Tripathi RP

更新日期：2006-12-01 00:00:00

abstract：:On May 6th 2014, the European Court of Human Rights added yet a new element to the judicial history of stem cells as it ruled in Durisotto v. Italy [appeal n. 62804/13]. The ruling rejected a patient claim to access an unproven cell therapy-an outcome that is certainly to be welcomed. However, this ruling is a missed ...

journal_title：Stem cells and development

authors： Rial-Sebbag E,Blasimme A

更新日期：2014-12-01 00:00:00

abstract：:In a previous study we established colony assays suitable for studying murine adult (2-4 months) pancreatic progenitor cells plated in semisolid media containing methylcellulose and extracellular matrix proteins. Using these assays, we found robust in vitro progenitor cell activities (multilineage differentiation and ...

journal_title：Stem cells and development

authors： Jin L,Feng T,Zerda R,Chen CC,Riggs AD,Ku HT

更新日期：2014-04-15 00:00:00

abstract：:Regenerating islet (Reg) proteins are involved in the proliferation and differentiation of diverse cell types. However, whether embryonic stem cells (ESCs) express Reg genes and their corresponding proteins remains unknown. In this study, we probed the expression of Reg family members by mouse ESCs (mESCs). Mouse Reg1...

journal_title：Stem cells and development

authors： Jing D,Kehoe DE,Tzanakakis ES

更新日期：2010-09-01 00:00:00

abstract：:In this study, we isolated and characterized spontaneously differentiated human embryonic stem cells (SD-hESCs) found in hESC colonies in comparison to the morphologically premature ESCs in the colonies to investigate the potential role of SD-hESCs in embryogenesis. SD-hESCs were distinguished from undifferentiated hE...

journal_title：Stem cells and development

authors： Lee JH,Hong KS,Mantel C,Broxmeyer HE,Lee MR,Kim KS

更新日期：2013-10-15 00:00:00

abstract：:Special features of mesenchymal stem cells (MSCs) have made them a popular tool in cell therapy and tissue engineering. Although mouse animal models and murine MSCs are common tools in this field, our understanding of the effect of in vitro expansion on the behavior of these cells is poor and controversial. In additio...

journal_title：Stem cells and development

authors： Ahmadbeigi N,Soleimani M,Gheisari Y,Vasei M,Amanpour S,Bagherizadeh I,Shariati SA,Azadmanesh K,Amini S,Shafiee A,Arabkari V,Nardi NB

更新日期：2011-08-01 00:00:00

abstract：:Multipotent mesenchymal stem/stromal cells (MSCs) are strongly involved in tissue homeostasis mainly through paracrine regulation. In this study, we examined the influence of simulated microgravity on the angiogenic potential of adipose-derived MSCs (ASCs). The conditioned medium (CM) from random positioning machine (...

journal_title：Stem cells and development

authors： Ratushnyy A,Ezdakova M,Yakubets D,Buravkova L

更新日期：2018-06-15 00:00:00

abstract：:PU.1 is a versatile hematopoietic cell-specific ETS-family transcriptional regulator required for the development of both the inborn and the adaptive immunity, owing to its potential ability to regulate the expression of multiple genes specific for different lineages during normal hematopoiesis. It functions in a cell...

journal_title：Stem cells and development

authors： Gangenahalli GU,Gupta P,Saluja D,Verma YK,Kishore V,Chandra R,Sharma RK,Ravindranath T

更新日期：2005-04-01 00:00:00

abstract：:Neural stem cells (NSCs) have become promising tools for basic research and regenerative medicine. Intracerebral transplantation studies have suggested that these cells may be able to adopt neuronal phenotypes typical of their engraftment site and to establish appropriate connections in the recipient circuitries. Here...

journal_title：Stem cells and development

authors： Brilli E,Reitano E,Conti L,Conforti P,Gulino R,Consalez GG,Cesana E,Smith A,Rossi F,Cattaneo E

更新日期：2013-02-15 00:00:00

abstract：:Myocardial infarction (MI) results in loss of myofibers in the ischemic zone of the heart, followed by scar formation. These factors increase barriers to mobilization of mesenchymal stem cells (MSC), thereby impeding their effectiveness in cardiac repair. This study examined MSC overexpressing CXCR4 (MSC(CX4)) to dete...

journal_title：Stem cells and development

authors： Huang W,Wang T,Zhang D,Zhao T,Dai B,Ashraf A,Wang X,Xu M,Millard RW,Fan GC,Ashraf M,Yu XY,Wang Y

更新日期：2012-03-20 00:00:00

abstract：:A murine stromal cell line (OP9-DL1) expressing a notch ligand, Delta-like-1, has been shown to be able to drive the differentiation of both murine and human hematopoietic progenitors into T cells in vitro. Further studies showed that hematopoietic progenitors transduced by a retroviral vector to express a human CD8 T...

journal_title：Stem cells and development

authors： Dai B,Wang P

更新日期：2009-03-01 00:00:00

abstract：:Subarachnoid hemorrhage (SAH) is a type of hemorrhagic stroke with significant morbidity and mortality, and it often leads to poor clinical outcome. Although great efforts have been made toward animal and clinical studies, optimal therapy of SAH remains a challenge for scientists and clinicians. Increasing evidence su...

journal_title：Stem cells and development

authors： Song Z,Zhang JH

更新日期：2020-02-15 00:00:00

abstract：:Osteogenesis imperfecta (OI) is a genetic bone pathology with prenatal onset, characterized by brittle bones in response to abnormal collagen composition. There is presently no cure for OI. We previously showed that human first trimester fetal blood mesenchymal stem cells (MSCs) transplanted into a murine OI model (oi...

journal_title：Stem cells and development

authors： Jones GN,Moschidou D,Abdulrazzak H,Kalirai BS,Vanleene M,Osatis S,Shefelbine SJ,Horwood NJ,Marenzana M,De Coppi P,Bassett JH,Williams GR,Fisk NM,Guillot PV

更新日期：2014-02-01 00:00:00