Mathematical modeling and stability analysis of macrophage activation in left ventricular remodeling post-myocardial infarction.

abstract：BACKGROUND:NGS data contains many machine-induced errors. The most advanced methods for the error correction heavily depend on the selection of solid k-mers. A solid k-mer is a k-mer frequently occurring in NGS reads. The other k-mers are called weak k-mers. A solid k-mer does not likely contain errors, while a weak k-...

journal_title：BMC genomics

authors： Zhao L,Xie J,Bai L,Chen W,Wang M,Zhang Z,Wang Y,Zhao Z,Li J

更新日期：2018-12-31 00:00:00

abstract：BACKGROUND:A high caloric diet, in conjunction with low levels of physical activity, promotes obesity. Many studies are available regarding the relation between dietary saturated fats and the etiology of obesity, but most focus on liver, muscle and white adipose tissue. Furthermore, the majority of transcriptomic studi...

journal_title：BMC genomics

authors： Nyima T,Müller M,Hooiveld GJ,Morine MJ,Scotti M

更新日期：2016-02-09 00:00:00

abstract：BACKGROUND:Cadmium (Cd) is a severe detrimental environmental pollutant. To adapt to Cd-induced deleterious effects, plants have evolved sophisticated defence mechanisms. In this study, a genome-wide transcriptome analysis was performed to identify the mechanisms of Cd tolerance using two barley genotypes with distinct...

journal_title：BMC genomics

authors： Cao F,Chen F,Sun H,Zhang G,Chen ZH,Wu F

更新日期：2014-07-19 00:00:00

abstract：BACKGROUND:There is an increasing interest in berries, especially blackberries in the diet, because of recent reports of their health benefits due to their high content of flavonoids. A broad range of genomic tools are available for other Rosaceae species but these tools are still lacking in the Rubus genus, thus limit...

journal_title：BMC genomics

authors： Garcia-Seco D,Zhang Y,Gutierrez-Mañero FJ,Martin C,Ramos-Solano B

更新日期：2015-01-22 00:00:00

abstract：BACKGROUND:High throughput genotyping of single nucleotide polymorphisms (SNPs) for genome-wide association requires technologies for generating millions of genotypes with relative ease but also at a reasonable cost and with high accuracy. In this work, we have developed a theoretical approach to estimate allele freque...

journal_title：BMC genomics

authors： Yin BC,Li H,Ye BC

更新日期：2008-12-16 00:00:00

abstract：BACKGROUND:One of the most common and recurrent vaginal infections is bacterial vaginosis (BV). The diagnosis is based on changes to the "normal" vaginal microbiome; however, the normal microbiome appears to differ according to reproductive status and ethnicity, and even among individuals within these groups. The Amsel...

journal_title：BMC genomics

authors： Chen HM,Chang TH,Lin FM,Liang C,Chiu CM,Yang TL,Yang T,Huang CY,Cheng YN,Chang YA,Chang PY,Weng SL

更新日期：2018-12-31 00:00:00

abstract：UNLABELLED:Little is known, either experimentally or computationally, about the genomic sequence features that regulate malaria genes. A sequence conservation analysis of the malaria species P. falciparum, P. berghei, P. yoelii, and P. chabaudi could significantly advance knowledge of malaria gene regulation. RESULTS:...

journal_title：BMC genomics

authors： Imamura H,Persampieri JH,Chuang JH

更新日期：2007-10-15 00:00:00

abstract：BACKGROUND:The genomic organisation of the Major Histocompatibility Complex (MHC) varies greatly between different vertebrates. In mammals, the classical MHC consists of a large number of linked genes (e.g. greater than 200 in humans) with predominantly immune function. In some birds, it consists of only a small number...

journal_title：BMC genomics

authors： Sambrook JG,Figueroa F,Beck S

更新日期：2005-11-04 00:00:00

abstract：BACKGROUND:V(D)J recombinations in lymphocytes are essential for immunological diversity. They are also useful markers of pathologies. In leukemia, they are used to quantify the minimal residual disease during patient follow-up. However, the full breadth of lymphocyte diversity is not fully understood. RESULTS:We prop...

journal_title：BMC genomics

authors： Giraud M,Salson M,Duez M,Villenet C,Quief S,Caillault A,Grardel N,Roumier C,Preudhomme C,Figeac M

更新日期：2014-05-28 00:00:00

abstract：BACKGROUND:Species of the family Vibrionaceae are ubiquitous in marine environments. Several of these species are important pathogens of humans and marine species. Evidence indicates that genetic exchange plays an important role in the emergence of new pathogenic strains within this family. Data from the sequenced geno...

journal_title：BMC genomics

authors： Lilburn TG,Gu J,Cai H,Wang Y

更新日期：2010-06-10 00:00:00

abstract：BACKGROUND:Genomic approaches provide unique opportunities to study interactions of insects with their pathogens. We developed a cDNA microarray to analyze the gene transcription profile of the lepidopteran pest Spodoptera frugiperda in response to injection of the polydnavirus HdIV associated with the ichneumonid wasp...

journal_title：BMC genomics

authors： Barat-Houari M,Hilliou F,Jousset FX,Sofer L,Deleury E,Rocher J,Ravallec M,Galibert L,Delobel P,Feyereisen R,Fournier P,Volkoff AN

更新日期：2006-06-21 00:00:00

abstract：BACKGROUND:Protein Disulfide Isomerases are thiol oxidoreductase chaperones from thioredoxin superfamily with crucial roles in endoplasmic reticulum proteostasis, implicated in many diseases. The family prototype PDIA1 is also involved in vascular redox cell signaling. PDIA1 is coded by the P4HB gene. While forced chan...

journal_title：BMC genomics

authors： Kajihara D,Hon CC,Abdullah AN,Wosniak J Jr,Moretti AIS,Poloni JF,Bonatto D,Hashimoto K,Carninci P,Laurindo FRM

更新日期：2020-11-04 00:00:00

abstract：BACKGROUND:Many computational methods are available for assembly and annotation of newly sequenced microbial genomes. However, when new genomes are reported in the literature, there is frequently very little critical analysis of choices made during the sequence assembly and gene annotation stages. These choices have a ...

journal_title：BMC genomics

authors： Morrison SS,Pyzh R,Jeon MS,Amaro C,Roig FJ,Baker-Austin C,Oliver JD,Gibas CJ

更新日期：2014-01-01 00:00:00

abstract：BACKGROUND:Gene expression analysis by reverse transcription quantitative PCR (qPCR) is the most widely used method for analyzing the expression of a moderate number of genes and also for the validation of microarray results. Several issues are crucial for a successful qPCR study, particularly the selection of internal...

journal_title：BMC genomics

authors： Robledo D,Hernández-Urcera J,Cal RM,Pardo BG,Sánchez L,Martínez P,Viñas A

更新日期：2014-08-04 00:00:00

abstract：BACKGROUND:Aedes aegypti is the principle vector of many arboviruses, including dengue virus and Zika virus, which are transmitted when an infected female mosquito takes a blood meal in order to initiate vitellogenesis. During blood digestion, ~ 10 mM heme-iron is ingested into the midgut lumen. While heme acts as both...

journal_title：BMC genomics

authors： Eggleston H,Adelman ZN

更新日期：2020-08-31 00:00:00

abstract：BACKGROUND:Daphnia (Crustacea: Cladocera) plays a central role in standing aquatic ecosystems, has a well known ecology and is widely used in population studies and environmental risk assessments. Daphnia magna is, especially in Europe, intensively used to study stress responses of natural populations to pollutants, cl...

journal_title：BMC genomics

authors： Orsini L,Jansen M,Souche EL,Geldof S,De Meester L

更新日期：2011-06-13 00:00:00

abstract：BACKGROUND:The introduction of genome-wide shRNA and CRISPR libraries has facilitated cell-based screens to identify loss-of-function mutations associated with a phenotype of interest. Approaches to perform analogous gain-of-function screens are less common, although some reports have utilized arrayed viral expression ...

journal_title：BMC genomics

authors： Feddersen CR,Wadsworth LS,Zhu EY,Vaughn HR,Voigt AP,Riordan JD,Dupuy AJ

更新日期：2019-06-17 00:00:00

abstract：BACKGROUND:Pseudomonas aeruginosa is an opportunistic pathogen with a high incidence of hospital infections that represents a threat to immune compromised patients. Genomic studies have shown that, in contrast to other pathogenic bacteria, clinical and environmental isolates do not show particular genomic differences. ...

journal_title：BMC genomics

authors： Grosso-Becerra MV,Santos-Medellín C,González-Valdez A,Méndez JL,Delgado G,Morales-Espinosa R,Servín-González L,Alcaraz LD,Soberón-Chávez G

更新日期：2014-04-28 00:00:00

abstract：BACKGROUND:Dinoflagellates are unicellular marine and freshwater eukaryotes. They possess large nuclear genomes (1.5-245 gigabases) and produce structurally unique and biologically active polyketide secondary metabolites. Although polyketide biosynthesis is well studied in terrestrial and freshwater organisms, only rec...

journal_title：BMC genomics

authors： Beedessee G,Hisata K,Roy MC,Satoh N,Shoguchi E

更新日期：2015-11-14 00:00:00

abstract：BACKGROUND:Bacteriophages are the most abundant and diverse entities in the biosphere, and this diversity is driven by constant predator-prey evolutionary dynamics and horizontal gene transfer. Phage genome sequences are under-sampled and therefore present an untapped and uncharacterized source of genetic diversity, ty...

journal_title：BMC genomics

authors： Oliveira H,Sampaio M,Melo LDR,Dias O,Pope WH,Hatfull GF,Azeredo J

更新日期：2019-05-09 00:00:00

abstract：BACKGROUND:Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by inflammation and destruction of synovial joints. RA affects up to 1 % of the population worldwide. Currently, there are no drugs that can cure RA or achieve sustained remission. The unknown cause of the disease represents a significan...

journal_title：BMC genomics

authors： Xu R,Wang Q

更新日期：2016-08-22 00:00:00

abstract：BACKGROUND:Previous investigations of phylogeny in Cervus recovered many clades without whole genomic support. METHODS:In this study, the genetic diversity and phylogeny of 5 species (21 subspecies/populations from C. unicolor, C. albirostris, C. nippon, C. elaphus and C. eldii) in the genus Cervus were analyzed using...

journal_title：BMC genomics

authors： Hu P,Shao Y,Xu J,Wang T,Li Y,Liu H,Rong M,Su W,Chen B,Cui S,Cui X,Yang F,Tamate H,Xing X

更新日期：2019-05-17 00:00:00

abstract：BACKGROUND:The siRNA and piRNA pathways have been shown in insects to be essential for regulation of gene expression and defence against exogenous and endogenous genetic elements (viruses and transposable elements). The vast majority of endogenous small RNAs produced by the siRNA and piRNA pathways originate from repet...

journal_title：BMC genomics

authors： Biryukova I,Ye T

更新日期：2015-04-10 00:00:00

abstract：BACKGROUND:The nucleoli, including their proteomes, of higher eukaryotes have been extensively studied, while few studies about the nucleoli of the lower eukaryotes - protists were reported. Giardia lamblia, a protist with the controversy of whether it is an extreme primitive eukaryote or just a highly evolved parasite...

journal_title：BMC genomics

authors： Feng JM,Yang CL,Tian HF,Wang JX,Wen JF

更新日期：2020-03-30 00:00:00

abstract：BACKGROUND:Apple is an economically important fruit crop worldwide. Developing a genetic linkage map is a critical step towards mapping and cloning of genes responsible for important horticultural traits in apple. To facilitate linkage map construction, we surveyed and characterized the distribution and frequency of pe...

journal_title：BMC genomics

authors： Zhang Q,Ma B,Li H,Chang Y,Han Y,Li J,Wei G,Zhao S,Khan MA,Zhou Y,Gu C,Zhang X,Han Z,Korban SS,Li S,Han Y

更新日期：2012-10-07 00:00:00

abstract：BACKGROUND:Myostatin, a muscle-specific member of the Transforming Growth Factor beta family, negatively regulates muscle development. Double-muscled (DM) cattle have a loss-of-function mutation in their myostatin gene responsible for the hypermuscular phenotype. Thus, these animals are a good model for understanding t...

journal_title：BMC genomics

authors： Cassar-Malek I,Passelaigue F,Bernard C,Léger J,Hocquette JF

更新日期：2007-03-01 00:00:00

abstract：BACKGROUND:Genotype imputation can help reduce genotyping costs particularly for implementation of genomic selection. In applications entailing large populations, recovering the genotypes of untyped loci using information from reference individuals that were genotyped with a higher density panel is computationally chal...

journal_title：BMC genomics

authors： Sargolzaei M,Chesnais JP,Schenkel FS

更新日期：2014-06-17 00:00:00

abstract：BACKGROUND:Mycobacterium abscessus complex, the third most frequent mycobacterial complex responsible for community- and health care-associated infections in developed countries, comprises of M. abscessus subsp. abscessus and M. abscessus subsp. bolletii reviously referred as Mycobacterium bolletii and Mycobacterium ma...

journal_title：BMC genomics

authors： Sassi M,Drancourt M

更新日期：2014-05-12 00:00:00

abstract：BACKGROUND:Genome-wide association studies have revealed associations between single-nucleotide polymorphisms (SNPs) and phenotypes such as disease symptoms and drug tolerance. To address the small sample size for rare variants, association studies tend to group gene or pathway level variants and evaluate the effect on...

journal_title：BMC genomics

authors： Hasegawa T,Kojima K,Kawai Y,Misawa K,Mimori T,Nagasaki M

更新日期：2016-09-21 00:00:00

abstract：BACKGROUND:The substantially large bread wheat genome, organized into highly similar three sub-genomes, renders genomic research challenging. The construction of BAC-based physical maps of individual chromosomes reduces the complexity of this allohexaploid genome, enables elucidation of gene space and evolutionary rela...

journal_title：BMC genomics

authors： Akpinar BA,Magni F,Yuce M,Lucas SJ,Šimková H,Šafář J,Vautrin S,Bergès H,Cattonaro F,Doležel J,Budak H

更新日期：2015-06-13 00:00:00