Hill-type muscle model parameters determined from experiments on single muscles show large animal-to-animal variation.

Abstract:

:Models built using mean data can represent only a very small percentage, or none, of the population being modeled, and produce different activity than any member of it. Overcoming this "averaging" pitfall requires measuring, in single individuals in single experiments, all of the system's defining characteristics. We have developed protocols that allow all the parameters in the curves used in typical Hill-type models (passive and active force-length, series elasticity, force-activation, force-velocity) to be determined from experiments on individual stick insect muscles (Blümel et al. 2012a). A requirement for means to not well represent the population is that the population shows large variation in its defining characteristics. We therefore used these protocols to measure extensor muscle defining parameters in multiple animals. Across-animal variability in these parameters can be very large, ranging from 1.3- to 17-fold. This large variation is consistent with earlier data in which extensor muscle responses to identical motor neuron driving showed large animal-to-animal variability (Hooper et al. 2006), and suggests accurate modeling of extensor muscles requires modeling individual-by-individual. These complete characterizations of individual muscles also allowed us to test for parameter correlations. Two parameter pairs significantly co-varied, suggesting that a simpler model could as well reproduce muscle response.

journal_name

Biol Cybern

journal_title

Biological cybernetics

authors

Blümel M,Guschlbauer C,Daun-Gruhn S,Hooper SL,Büschges A

doi

10.1007/s00422-012-0530-6

subject

Has Abstract

pub_date

2012-11-01 00:00:00

pages

559-71

issue

10

eissn

0340-1200

issn

1432-0770

journal_volume

106

pub_type

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