B chromosome in the beetle Coprophanaeus cyanescens (Scarabaeidae): emphasis in the organization of repetitive DNA sequences.

Abstract:

BACKGROUND:To contribute to the knowledge of coleopteran cytogenetics, especially with respect to the genomic content of B chromosomes, we analyzed the composition and organization of repetitive DNA sequences in the Coprophanaeus cyanescens karyotype. We used conventional staining and the application of fluorescence in situ hybridization (FISH) mapping using as probes C0t-1 DNA fraction, the 18S and 5S rRNA genes, and the LOA-like non-LTR transposable element (TE). RESULTS:The conventional analysis detected 3 individuals (among 50 analyzed) carrying one small metacentric and mitotically unstable B chromosome. The FISH analysis revealed a pericentromeric block of C0t-1 DNA in the B chromosome but no 18S or 5S rDNA clusters in this extra element. Using the LOA-like TE probe, the FISH analysis revealed large pericentromeric blocks in eight autosomal bivalents and in the B chromosome, and a pericentromeric block extending to the short arm in one autosomal pair. No positive hybridization signal was observed for the LOA-like element in the sex chromosomes. CONCLUSIONS:The results indicate that the origin of the B chromosome is associated with the autosomal elements, as demonstrated by the hybridization with C0t-1 DNA and the LOA-like TE. The present study is the first report on the cytogenetic mapping of a TE in coleopteran chromosomes. These TEs could have been involved in the origin and evolution of the B chromosome in C. cyanescens.

journal_name

BMC Genet

journal_title

BMC genetics

authors

Gomes de Oliveira S,Cassia de Moura R,Martins C

doi

10.1186/1471-2156-13-96

subject

Has Abstract

pub_date

2012-11-06 00:00:00

pages

96

issn

1471-2156

pii

1471-2156-13-96

journal_volume

13

pub_type

杂志文章
  • Hemi-nested touchdown PCR combined with primer-template mismatch PCR for rapid isolation and sequencing of low molecular weight glutenin subunit gene family from a hexaploid wheat BAC library.

    abstract:BACKGROUND:Hexaploid wheat (Triticum aestivum L.) possesses a large genome that contains 1.6 x 1010 bp of DNA. Isolation of a large number of gene sequences from complex gene families with a high level of gene sequence identity from genomic DNA is therefore difficult and time-consuming. Bacterial artificial chromosome ...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-8-18

    authors: Huang XQ,Cloutier S

    更新日期:2007-05-04 00:00:00

  • The challenge for genetic epidemiologists: how to analyze large numbers of SNPs in relation to complex diseases.

    abstract::Genetic epidemiologists have taken the challenge to identify genetic polymorphisms involved in the development of diseases. Many have collected data on large numbers of genetic markers but are not familiar with available methods to assess their association with complex diseases. Statistical methods have been developed...

    journal_title:BMC genetics

    pub_type: 社论

    doi:10.1186/1471-2156-7-23

    authors: Heidema AG,Boer JM,Nagelkerke N,Mariman EC,van der A DL,Feskens EJ

    更新日期:2006-04-21 00:00:00

  • Quantitative trait loci for variation in immune response to a Foot-and-Mouth Disease virus peptide.

    abstract:BACKGROUND:Infectious disease of livestock continues to be a cause of substantial economic loss and has adverse welfare consequences in both the developing and developed world. New solutions to control disease are needed and research focused on the genetic loci determining variation in immune-related traits has the pot...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-11-107

    authors: Leach RJ,Craigmile SC,Knott SA,Williams JL,Glass EJ

    更新日期:2010-12-07 00:00:00

  • Refining associations between TAS2R38 diplotypes and the 6-n-propylthiouracil (PROP) taste test: findings from the Avon Longitudinal Study of Parents and Children.

    abstract:BACKGROUND:Previous investigations have highlighted the importance of genetic variation in the determination of bitter tasting ability, however have left unaddressed questions as to within group variation in tasting ability or the possibility of genetic prescription of intermediate tasting ability. Our aim was to exami...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-8-51

    authors: Timpson NJ,Heron J,Day IN,Ring SM,Bartoshuk LM,Horwood J,Emmett P,Davey-Smith G

    更新日期:2007-07-28 00:00:00

  • Computational cloning of drug target genes of a parasitic nematode, Oesophagostomum dentatum.

    abstract:BACKGROUND:Gene identification and sequence determination are critical requirements for many biological, genomic, and bioinformatic studies. With the advent of next generation sequencing (NGS) technologies, such determinations are predominantly accomplished in silico for organisms for which the genome is known or for w...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-14-55

    authors: Romine NM,Martin RJ,Beetham JK

    更新日期:2013-06-18 00:00:00

  • A second generation genetic map for rainbow trout (Oncorhynchus mykiss).

    abstract:BACKGROUND:Genetic maps characterizing the inheritance patterns of traits and markers have been developed for a wide range of species and used to study questions in biomedicine, agriculture, ecology and evolutionary biology. The status of rainbow trout genetic maps has progressed significantly over the last decade due ...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-9-74

    authors: Rexroad CE 3rd,Palti Y,Gahr SA,Vallejo RL

    更新日期:2008-11-19 00:00:00

  • Comparing self-reported ethnicity to genetic background measures in the context of the Multi-Ethnic Study of Atherosclerosis (MESA).

    abstract:BACKGROUND:Questions remain regarding the utility of self-reported ethnicity (SRE) in genetic and epidemiologic research. It is not clear whether conditioning on SRE provides adequate protection from inflated type I error rates due to population stratification and admixture. We address this question using data obtained...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-12-28

    authors: Divers J,Redden DT,Rice KM,Vaughan LK,Padilla MA,Allison DB,Bluemke DA,Young HJ,Arnett DK

    更新日期:2011-03-04 00:00:00

  • Population study of 1311 C/T polymorphism of Glucose 6 Phosphate Dehydrogenase gene in Pakistan - an analysis of 715 X-chromosomes.

    abstract:BACKGROUND:Nucleotide 1311 polymorphism at exon 11 of G6PD gene is widely prevalent in various populations of the world. The aim of the study was to evaluate 1311 polymorphism in subjects carrying G6PD Mediterranean gene and in general population living in Pakistan. RESULTS:Patients already known to be G6PD deficient ...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-10-41

    authors: Moiz B,Nasir A,Moatter T,Naqvi ZA,Khurshid M

    更新日期:2009-07-30 00:00:00

  • The transcription of MGAT4A glycosyl transferase is increased in white cells of peripheral blood of type 2 diabetes patients.

    abstract:BACKGROUND:Human glycosylase IV is involved in GLUT2 transporter regulation in pancreatic beta cells. A KO of this gene along with a high fat diet in a mice model has been associated with the development of type 2 diabetes (T2D). The aims of this study were to measure and compare the MGAT4A mRNA levels in white blood c...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-8-73

    authors: López-Orduña E,Cruz M,García-Mena J

    更新日期:2007-10-22 00:00:00

  • Genetic insights into dispersal distance and disperser fitness of African lions (Panthera leo) from the latitudinal extremes of the Kruger National Park, South Africa.

    abstract:BACKGROUND:Female lions generally do not disperse far beyond their natal range, while males can disperse distances of over 200 km. However, in bush-like ecosystems dispersal distances less than 25 km are reported. Here, we investigate dispersal in lions sampled from the northern and southern extremes of Kruger National...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/s12863-018-0607-x

    authors: van Hooft P,Keet DF,Brebner DK,Bastos ADS

    更新日期:2018-04-03 00:00:00

  • Bivariate linkage analysis of cholesterol and triglyceride levels in the Framingham Heart Study.

    abstract::We performed a bivariate analysis on cholesterol and triglyceride levels on data from the Framingham Heart Study using a new score statistic developed for the detection of potential pleiotropic, or cluster, genes. Univariate score statistics were also computed for each trait. At a significance level 0.001, linkage sig...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-4-S1-S62

    authors: Zhang X,Wang K,Framingham Heart Study.

    更新日期:2003-12-31 00:00:00

  • Genetic diversity assessment of sesame core collection in China by phenotype and molecular markers and extraction of a mini-core collection.

    abstract:BACKGROUND:Sesame (Sesamum indicum L.) is one of the four major oil crops in China. A sesame core collection (CC) was established in China in 2000, but no complete study on its genetic diversity has been carried out at either the phenotypic or molecular level. To provide technical guidance, a theoretical basis for furt...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-13-102

    authors: Zhang Y,Zhang X,Che Z,Wang L,Wei W,Li D

    更新日期:2012-11-15 00:00:00

  • Genomic selection in sugar beet breeding populations.

    abstract:BACKGROUND:Genomic selection exploits dense genome-wide marker data to predict breeding values. In this study we used a large sugar beet population of 924 lines representing different germplasm types present in breeding populations: unselected segregating families and diverse lines from more advanced stages of selectio...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-14-85

    authors: Würschum T,Reif JC,Kraft T,Janssen G,Zhao Y

    更新日期:2013-09-18 00:00:00

  • Diagnosis of alcoholism based on neural network analysis of phenotypic risk factors.

    abstract:BACKGROUND:Alcoholism is a serious public health problem. It has both genetic and environmental causes. In an effort to gain understanding of the underlying genetic susceptibility to alcoholism, a long-term study has been undertaken. The Collaborative Study on the Genetics of Alcoholism (COGA) provides a rich source of...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-6-S1-S131

    authors: Falk CT

    更新日期:2005-12-30 00:00:00

  • The prognostic value of IL10 and TNF alpha functional polymorphisms in premenopausal early-stage breast cancer patients.

    abstract:BACKGROUND:Interleukin-10 and tumor necrosis factor α play an important role in breast carcinogenesis. Genes, encoding those two cytokines, contain single nucleotide polymorphisms, which are associated with differential levels of gene transcription. This study analyzes single nucleotide polymorphisms in interleukin 10 ...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/s12863-015-0234-8

    authors: Korobeinikova E,Myrzaliyeva D,Ugenskiene R,Raulinaityte D,Gedminaite J,Smigelskas K,Juozaityte E

    更新日期:2015-06-26 00:00:00

  • Characterization of two MHC II genes (DOB, DRB) in white-tailed deer (Odocoileus virginianus).

    abstract:BACKGROUND:The major histocompatibility complex (MHC) is responsible for detecting and addressing foreign pathogens inside the body. While the general structure of MHC genes is relatively well conserved among mammalian species, it is notably different among ruminants due to a chromosomal inversion that splits MHC type ...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/s12863-020-00889-5

    authors: Ivy-Israel NMD,Moore CE,Schwartz TS,Ditchkoff SS

    更新日期:2020-07-29 00:00:00

  • An investigation of the effects of lipid-lowering medications: genome-wide linkage analysis of lipids in the HyperGEN study.

    abstract:BACKGROUND:Use of anti-hyperlipidemic medications compromises genetic analysis because of altered lipid profiles. We propose an empirical method to adjust lipid levels for medication effects so that the adjusted lipid values substitute the unmedicated lipid values in the genetic analysis. RESULTS:Published clinical tr...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-8-60

    authors: Wu J,Province MA,Coon H,Hunt SC,Eckfeldt JH,Arnett DK,Heiss G,Lewis CE,Ellison RC,Rao DC,Rice T,Kraja AT

    更新日期:2007-09-10 00:00:00

  • Quantitative trait locus analysis for pod- and kernel-related traits in the cultivated peanut (Arachis hypogaea L.).

    abstract:BACKGROUND:The cultivated peanut (Arachis hypogaea L.) is an important oil and food crop in the world. Pod- and kernel-related traits are direct factors involved in determining the yield of the peanut. However, the genetic basis underlying pod- and kernel-related traits in the peanut remained largely unknown, which ham...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/s12863-016-0337-x

    authors: Chen W,Jiao Y,Cheng L,Huang L,Liao B,Tang M,Ren X,Zhou X,Chen Y,Jiang H

    更新日期:2016-01-25 00:00:00

  • Association study of stuttering candidate genes GNPTAB, GNPTG and NAGPA with dyslexia in Chinese population.

    abstract:BACKGROUND:Dyslexia is a polygenic speech and language disorder characterized by an unexpected difficulty in reading in children and adults despite normal intelligence and schooling. Increasing evidence reveals that different speech and language disorders could share common genetic factors. As previous study reported a...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/s12863-015-0172-5

    authors: Chen H,Xu J,Zhou Y,Gao Y,Wang G,Xia J,Huen MS,Siok WT,Jiang Y,Tan LH,Sun Y

    更新日期:2015-02-03 00:00:00

  • An adaptive gene-level association test for pedigree data.

    abstract:BACKGROUND:We propose a gene-level association test that accounts for individual relatedness and population structures in pedigree data in the framework of linear mixed models (LMMs). Our method data-adaptively combines the results across a class of score-based tests, only requiring fitting a single null model (under t...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/s12863-018-0639-2

    authors: Park JY,Wu C,Pan W

    更新日期:2018-09-17 00:00:00

  • Mapping and validation of major quantitative trait loci for kernel length in wild barley (Hordeum vulgare ssp. spontaneum).

    abstract:BACKGROUND:Kernel length is an important target trait in barley (Hordeum vulgare L.) breeding programs. However, the number of known quantitative trait loci (QTLs) controlling kernel length is limited. In the present study, we aimed to identify major QTLs for kernel length, as well as putative candidate genes that migh...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/s12863-016-0438-6

    authors: Zhou H,Liu S,Liu Y,Liu Y,You J,Deng M,Ma J,Chen G,Wei Y,Liu C,Zheng Y

    更新日期:2016-09-13 00:00:00

  • Genetic diversity and population structure of the Sapsaree, a native Korean dog breed.

    abstract:BACKGROUND:The Sapsaree is a breed of dog (Canis familiaris) native to Korea, which became perilously close to extinction in the mid-1980s. However, with systematic genetic conservation and restoration efforts, this breed was rescued from extinction and population sizes have been gradually increasing over the past few ...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/s12863-019-0757-5

    authors: Gajaweera C,Kang JM,Lee DH,Lee SH,Kim YK,Wijayananda HI,Kim JJ,Ha JH,Choi BH,Lee SH

    更新日期:2019-08-05 00:00:00

  • LD2SNPing: linkage disequilibrium plotter and RFLP enzyme mining for tag SNPs.

    abstract:BACKGROUND:Linkage disequilibrium (LD) mapping is commonly used to evaluate markers for genome-wide association studies. Most types of LD software focus strictly on LD analysis and visualization, but lack supporting services for genotyping. RESULTS:We developed a freeware called LD2SNPing, which provides a complete pa...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-10-26

    authors: Chang HW,Chuang LY,Chang YJ,Cheng YH,Hung YC,Chen HC,Yang CH

    更新日期:2009-06-06 00:00:00

  • Identifying and exploiting gene-pathway interactions from RNA-seq data for binary phenotype.

    abstract:BACKGROUND:RNA sequencing (RNA-seq) technology has identified multiple differentially expressed (DE) genes associated to complex disease, however, these genes only explain a modest part of variance. Omnigenic model assumes that disease may be driven by genes with indirect relevance to disease and be propagated by funct...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/s12863-019-0739-7

    authors: Shao F,Wang Y,Zhao Y,Yang S

    更新日期:2019-03-19 00:00:00

  • Genome-enabled predictions for binomial traits in sugar beet populations.

    abstract:BACKGROUND:Genomic information can be used to predict not only continuous but also categorical (e.g. binomial) traits. Several traits of interest in human medicine and agriculture present a discrete distribution of phenotypes (e.g. disease status). Root vigor in sugar beet (B. vulgaris) is an example of binomial trait ...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-15-87

    authors: Biscarini F,Stevanato P,Broccanello C,Stella A,Saccomani M

    更新日期:2014-07-22 00:00:00

  • Characterisation of sugar beet (Beta vulgaris L. ssp. vulgaris) varieties using microsatellite markers.

    abstract:BACKGROUND:Sugar beet is an obligate outcrossing species. Varieties consist of mixtures of plants from various parental combinations. As the number of informative morphological characteristics is limited, this leads to some problems in variety registration research. RESULTS:We have developed 25 new microsatellite mark...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-11-41

    authors: Smulders MJ,Esselink GD,Everaert I,De Riek J,Vosman B

    更新日期:2010-05-18 00:00:00

  • Reassessment of the function of somatolactin alpha in lipid metabolism using medaka mutant and transgenic strains.

    abstract:BACKGROUND:Somatolactin alpha (SLa) is a fish-specific peptide hormone secreted from the pituitary. In medaka, SLa functions to darken the skin color and lack of SLa makes it pale. Transcription of SLa is enhanced or suppressed when fish are kept in dark or bright conditions, respectively, indicating SLa's important ro...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-13-64

    authors: Sasano Y,Yoshimura A,Fukamachi S

    更新日期:2012-07-24 00:00:00

  • Fusion of the NUP98 gene with the LEDGF/p52 gene defines a recurrent acute myeloid leukemia translocation.

    abstract:BACKGROUND:The NUP98 gene is involved in multiple rearrangements in haematological malignancy. The leukemic cells in an acute myeloid leukemia (AML) patient with a t(9;11)(p22;p15) were recently shown to have a fusion between the NUP98 gene and the LEDGF gene but it was not demonstrated that this fusion was recurrent i...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-2-20

    authors: Hussey DJ,Moore S,Nicola M,Dobrovic A

    更新日期:2001-01-01 00:00:00

  • A systematic search for SNPs/haplotypes associated with disease phenotypes using a haplotype-based stepwise procedure.

    abstract:BACKGROUND:Genotyping technologies enable us to genotype multiple Single Nucleotide Polymorphisms (SNPs) within selected genes/regions, providing data for haplotype association analysis. While haplotype-based association analysis is powerful for detecting untyped causal alleles in linkage-disequilibrium (LD) with neigh...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-9-90

    authors: Yang Y,Li SS,Chien JW,Andriesen J,Zhao LP

    更新日期:2008-12-22 00:00:00

  • Meta-analysis of haplotype-association studies: comparison of methods and empirical evaluation of the literature.

    abstract:BACKGROUND:Meta-analysis is a popular methodology in several fields of medical research, including genetic association studies. However, the methods used for meta-analysis of association studies that report haplotypes have not been studied in detail. In this work, methods for performing meta-analysis of haplotype assoc...

    journal_title:BMC genetics

    pub_type: 杂志文章

    doi:10.1186/1471-2156-12-8

    authors: Bagos PG

    更新日期:2011-01-19 00:00:00