Pegloticase and the patient with treatment-failure gout.

abstract：INTRODUCTION:Ocular dysfunctions and toxicities induced by antiepileptic drugs (AEDs) are rarely reviewed and not frequently received attention by treating physicians compared to other adverse effects (e.g. endocrinologic, cognitive and metabolic). However, some are frequent and progressive even in therapeutic concentr...

journal_title：Expert review of clinical pharmacology

authors： Hamed SA

更新日期：2019-04-01 00:00:00

abstract：INTRODUCTION:Joint hypermobility (JH) is the hallmark of many hereditary soft connective tissue disorders, including Ehlers-Danlos syndromes and related disorders, disorders of the TGFβ-pathway, lateral meningocele syndrome, arterial tortuosity syndrome, and cutis laxa syndromes. Contemporary practice separates individ...

journal_title：Expert review of clinical pharmacology

authors： Baban A,Castori M

更新日期：2018-07-01 00:00:00

abstract：INTRODUCTION:Gaucher disease (GD) is an autosomal recessive disorder resulting from the deficiency of the lysosomal enzyme glucocerebrosidase (b-glucosidase), associated with varying degrees of visceral, bone and central nervous system pathology, leading to wide phenotypic diversity. Response to therapy and clinical ou...

journal_title：Expert review of clinical pharmacology

authors： Gupta P,Pastores G

更新日期：2018-12-01 00:00:00

abstract：:The use of pharmacokinetic (PK) and pharmacodynamic (PD) data to inform antimalarial treatment regimens has accelerated in the past few decades, due in no small part to the stimulus provided by progressive development of parasite resistance to most of the currently available drugs. An understanding of the disposition,...

journal_title：Expert review of clinical pharmacology

authors： Davis TM,Moore BR,Salman S,Page-Sharp M,Batty KT,Manning L

更新日期：2016-01-01 00:00:00

abstract：:Neuroblastoma (NB) is the most common extra cranial solid tumor of childhood, with 60% of patients presenting with high risk (HR) NB by means of clinical, pathological and biological features. The 5-year survival rate for HR-NB remains below 40%, with the majority of patients suffering relapse from chemorefractory tum...

journal_title：Expert review of clinical pharmacology

authors： Mora J

更新日期：2016-01-01 00:00:00

abstract：:Magnetic nanoparticles (MNPs) represent a promising nanomaterial for the targeted therapy and imaging of malignant brain tumors. Conjugation of peptides or antibodies to the surface of MNPs allows direct targeting of the tumor cell surface and potential disruption of active signaling pathways present in tumor cells. D...

journal_title：Expert review of clinical pharmacology

authors： Wankhede M,Bouras A,Kaluzova M,Hadjipanayis CG

更新日期：2012-03-01 00:00:00

abstract：:The problem of adverse drug reactions is a well-documented global public health problem. Recent withdrawals of several widely used prescription medications in the USA and other countries have raised concerns among patients, clinicians, scientists and policy makers. The increasing interest and concern regarding withdra...

journal_title：Expert review of clinical pharmacology

authors： Issa AM

更新日期：2008-03-01 00:00:00

abstract：:Angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) are effective and widely used antihypertensive drugs. Exposure to these agents is known to be harmful to the fetus in the second and third trimesters of pregnancy. Concerns have also been raised about the risk of congenital malfo...

journal_title：Expert review of clinical pharmacology

authors： Pucci M,Sarween N,Knox E,Lipkin G,Martin U

更新日期：2015-03-01 00:00:00

abstract：:The last decades were characterized by enormous technological advances resulting in a better understanding of disease pathologies and improvement of treatment strategies. The development of targeted drugs, whose beginning can be traced back to Paul Ehrlich's theory of the 'magic bullet' approximately 100 years ago, is...

journal_title：Expert review of clinical pharmacology

authors： Hebar A,Valent P,Selzer E

更新日期：2013-01-01 00:00:00

abstract：:Bone metastases are associated with a broad spectrum of clinical sequelae. Pain, reduced mobility, skeletal complications and treatment-related events reduce quality of life. Numerous randomized controlled trials have evaluated pharmacological interventions to treat bone metastases. The primary outcomes used have evol...

journal_title：Expert review of clinical pharmacology

authors： Ford JA,Mowatt G,Jones R

更新日期：2012-05-01 00:00:00

abstract：:Schizophrenia is a major mental illness with a lifetime prevalence of about 1%. Antipsychotic drugs, with a primary mechanism of action that involves dopamine receptor blockade, are the mainstay in the treatment of the disorder. However, despite optimum antipsychotic treatment, few patients return to pre-morbid levels...

journal_title：Expert review of clinical pharmacology

authors： Andrade C

更新日期：2016-01-01 00:00:00

abstract：:In acute myocardial ischemia (AMI) the optimal treatment is rapid revascularization by angioplasty or pharmacological thrombolysis. While this is essential to resuscitate the ischemic myocardium, it results in further reperfusion injury and extension of the infarction. The main hypothesis for the mechanism of reperfus...

journal_title：Expert review of clinical pharmacology

authors： Qin C,Yap S,Woodman OL

更新日期：2009-11-01 00:00:00

abstract：:Globally, it is possible that less than half of all patients are treated in compliance with guidelines and more than half of all patients fail to take their medicines as prescribed or dispensed. Such inappropriate use is wasteful of resources and causes patient harm in terms of lack of satisfactory outcome, serious ad...

journal_title：Expert review of clinical pharmacology

authors： Holloway KA

更新日期：2011-05-01 00:00:00

abstract：INTRODUCTION:The need to develop new drugs for the control of pathogenic microorganisms has redoubled efforts to prospect for antimicrobial peptides (AMPs) from natural sources and to characterize its structure and function. These molecules present a broad spectrum of action against different microorganisms and frequen...

journal_title：Expert review of clinical pharmacology

authors： Sampaio de Oliveira KB,Leite ML,Rodrigues GR,Duque HM,da Costa RA,Cunha VA,de Loiola Costa LS,da Cunha NB,Franco OL,Dias SC

更新日期：2020-04-01 00:00:00

abstract：INTRODUCTION:The broad use of immunotherapy is revolutionizing the treatment paradigms of many solid tumors. Although chemotherapy remains the treatment backbone for advanced gastric cancer, improvements in its molecular characterization and progresses in understanding its underpinning biology have supported clinical d...

journal_title：Expert review of clinical pharmacology

authors： Bonotto M,Garattini SK,Basile D,Ongaro E,Fanotto V,Cattaneo M,Cortiula F,Iacono D,Cardellino GG,Pella N,Fasola G,Antonuzzo L,Silvestris N,Aprile G

更新日期：2017-06-01 00:00:00

abstract：:'IDegLira' combines insulin degludec (IDeg) with the glucagon-like peptide-1 analog liraglutide (Lira) at a ratio of 1 unit IDeg to 0.036 mg Lira. The two components have complementary therapeutic actions for the treatment of Type 2 diabetes. Studies have shown that combinations of basal insulin with glucagon-like pep...

journal_title：Expert review of clinical pharmacology

authors： Simpson R,King A

更新日期：2015-03-01 00:00:00

abstract：:Knee osteoarthritis is the most common form of arthritis. Given the aging of the world's population, the burden of this disease is expected to increase significantly over the next few decades. As a pharmacological agent, glucosamine has been investigated for the treatment of symptoms and progression of knee osteoarthr...

journal_title：Expert review of clinical pharmacology

authors： Altman RD

更新日期：2009-07-01 00:00:00

abstract：:Reducing the burden of falciparum malaria in pregnancy is an urgent international public health priority but one that involves considerable challenges. The rapidly declining effectiveness of agents known to be safe in pregnancy, and the limited efficacy, safety and pharmacokinetic data available for many other antimal...

journal_title：Expert review of clinical pharmacology

authors： Vallely A,McCarthy J,Changalucha J,Vallely L,Chandramohan D

更新日期：2008-01-01 00:00:00

abstract：:Sugammadex, a modified γ-cyclodextrin, is the first selective relaxant binding agent. Sugammadex forms very tight complexes in a 1:1 ratio with steroidal neuromuscular blocking agents (rocuronium > vecuronium > pancuronium). This guest-host complex, which exists in equilibrium, is stable because of its very high assoc...

journal_title：Expert review of clinical pharmacology

authors： Naguib M,Brull SJ

更新日期：2009-01-01 00:00:00

abstract：INTRODUCTION:Osteoarthritis is the most common cause of arthritis and one of the main causes of chronic pain. Although opioids are frequently employed for chronic pain treatment, their usage for osteoarthritis pain remains controversial due to the associated adverse effects. Most guidelines reserve their use for refrac...

journal_title：Expert review of clinical pharmacology

authors： Ruiz Iban MA,Benavides J,Forero JP,Bittelman S,Martinez R,Mite MA,Diaz Heredia J,Ulloa S,Lizárraga Ferrand MM

更新日期：2018-01-01 00:00:00

abstract：:Valproic acid is approved for treatment of seizures and manic episodes of bipolar disorder, and continues to be one of the most commonly prescribed antiepileptic drugs in the world. Hepatotoxicity is a rare but serious side effect resulting from its use, particularly in young patients. This adverse effect does not dis...

journal_title：Expert review of clinical pharmacology

authors： Felker D,Lynn A,Wang S,Johnson DE

更新日期：2014-03-01 00:00:00

abstract：:C-X-C chemokine receptor (CXCR)3 and its interferon(IFN)γ-dependent chemokines (CXCL10, CXCL9, CXCL11) are implicated in the immune-pathogenesis of autoimmune thyroiditis (AT), Graves disease (GD) and Graves Ophthalmopathy (GO). In tissue, recruited Th1 lymphocytes produce IFNγ, enhancing the tissue secretion of IFNγ-...

journal_title：Expert review of clinical pharmacology

authors： Fallahi P,Ferrari SM,Elia G,Nasini F,Colaci M,Giuggioli D,Vita R,Benvenga S,Ferri C,Antonelli A

更新日期：2016-06-01 00:00:00

abstract：:Calcineurin inhibitors are widely used as maintenance immunosuppressants in solid-organ transplantation to minimize the risk of allograft rejection. Although the use of these agents has transformed the outcomes for patient and graft survival, this has come at a cost, notably the well-known adverse events of nephrotoxi...

journal_title：Expert review of clinical pharmacology

authors： Garcia-Saenz-de-Sicilia M,Mukherjee S

更新日期：2012-09-01 00:00:00

abstract：:Background: The RESORT trial showed no longer relapse free survival (RFS) with sorafenib following radical metastasectomy in metastatic renal cell carcinoma. We present the updated 42-month follow-up data. Methods: The phase II RESORT trial randomized patients to sorafenib or observation within 12 weeks from surgery. ...

journal_title：Expert review of clinical pharmacology

authors： Mennitto A,Verzoni E,Cognetti F,Miceli R,Milella M,Mosca A,Chiuri VE,Bearz A,Morelli F,Ortega C,Atzori F,Donini M,Claps M,Guadalupi V,Sepe P,Cappelletti V,de Braud FG,Procopio G

更新日期：2021-01-31 00:00:00

abstract：:Methotrexate is an antifolate agent used in the treatment of various cancers and some autoimmune diseases. In oncology, methotrexate is frequently administered at a high dose (>1 g/m(2)) and comes with various procedures to reduce the occurrence of toxicity and particularly to ensure optimal renal elimination. Drug-dr...

journal_title：Expert review of clinical pharmacology

authors： Levêque D,Santucci R,Gourieux B,Herbrecht R

更新日期：2011-11-01 00:00:00

abstract：INTRODUCTION:Checkpoint inhibitor immunotherapy has revolutionized the treatment of many advanced stage cancers. Preexisting immunity is necessary for a response to these agents, which are most effective in inflamed tumors since they principally act by reinforcing preexisting antitumor T-cell responses. An important go...

journal_title：Expert review of clinical pharmacology

authors： Festino L,Vanella V,Trojaniello C,Ascierto PA

更新日期：2018-10-01 00:00:00

abstract：:The dramatic effectiveness of statins in improving the course of atherosclerotic cardiovascular disease tends to overshadow questions of statin intolerance. Thus after more than 25 years of clinical statin use, intolerance remains a poorly understood, frustrating issue for patients and providers. It has been extraordi...

journal_title：Expert review of clinical pharmacology

authors： Guyton JR,Campbell KB,Lakey WC

更新日期：2014-01-01 00:00:00

abstract：:Over the last two decades, research developments have revolutionized our understanding of the pathogenesis of psoriasis and of the contribution of several cytokines in the manifestation of the disease. The key role of TNF-α in the pathogenesis of psoriasis has been extensively studied and its therapeutic action, initi...

journal_title：Expert review of clinical pharmacology

authors： Vergou T,Moustou AE,Sfikakis PP,Antoniou C,Stratigos AJ

更新日期：2011-07-01 00:00:00

abstract：:Chronic diarrhea remains a common condition that affects people infected with human immunodeficiency virus (HIV) despite the widespread use of potent antiretroviral therapy. It is important that providers control this condition, as the persistence of diarrhea affects the quality of life of patients and may contribute ...

journal_title：Expert review of clinical pharmacology

authors： Castro JG,Chin-Beckford N

更新日期：2015-01-01 00:00:00

abstract：:The unprecedented levels of political, technical and financial support for improved malaria control, and particularly for changes in the malaria treatment policy, have heralded a renewed appreciation of the role of pharmacovigilance, its relationship with other areas of public health and the development of novel appro...

journal_title：Expert review of clinical pharmacology

authors： Mehta U,Allen E,Barnes KI

更新日期：2010-07-01 00:00:00