Abstract:
:In our previous study, an anti-angiotensin I converting enzyme (ACE) peptide (Ala-His-Ile-Ile-Ile, MW: 565.3Da) was isolated from Styela clava flesh tissue. In this study the fractions obtained during the isolation process and the finally purified peptide were examined to see if they had vasorelaxation effects in isolated rat aortas, and then the peptide was investigated for anti-hypertensive effect in spontaneously hypertensive rats (SHRs). The induction of vasorelaxation in the rat aortas was observed with the isolated fractions and the peptide from the enzymatic hydrolysate of S. clava flesh tissue and could be markedly blocked by pretreatment with the nitric oxide synthase (NOS) inhibitor, N(G)-nitro-l-arginine methyl ester (l-NAME). In human endothelial cells, NO synthesis was found to be increased and eNOS phosphorylation was upregulated when the cells were cultured with the purified peptide. Furthermore, systolic blood pressure was reduced by administration of the potent vasorelaxation peptide in SHRs.
journal_name
Food Chemjournal_title
Food chemistryauthors
Ko SC,Kim DG,Han CH,Lee YJ,Lee JK,Byun HG,Lee SC,Park SJ,Lee DH,Jeon YJdoi
10.1016/j.foodchem.2012.02.210subject
Has Abstractpub_date
2012-09-15 00:00:00pages
1141-5issue
2eissn
0308-8146issn
1873-7072pii
S0308-8146(12)00425-6journal_volume
134pub_type
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