Abstract：
INTRODUCTION:Lymph node metastases represent a diagnostic and management challenge in patients with disseminated medullary thyroid carcinoma (MTC). Our understanding of microRNA (miRNA) profiles of metastatic disease also remains limited and may unveil novel therapeutic strategies for these patients. METHODS:MTC patients with a history of total thyroidectomy and lymph node dissection were identified from within the prospective Sydney University Endocrine Surgical Unit database. Patients with available formalin-fixed paraffin-embedded tumour tissue were included and clinicopathological data were collated. Total RNA was extracted and quantitave polymerase chain reaction (qPCR) analysis performed on the primary tumour and a corresponding lymph node metastasis for expression of miRNAs of proven significance in MTC (miR-9*, miR-183 and miR-375). RESULTS:Tissue was available for analysis in seven patients. The median age at diagnosis was 55 years (range: 22-67). Median tumour size was 18 mm (range: 6-55) and over a median follow-up period of 34 months (range: 1-210), five further operations were undertaken for residual disease. One patient died of metastatic disease. Pairwise correlations of qPCR expression levels between primary tumours and corresponding lymph node metastases revealed significant correlations for miR-9* (P < 0.001), miR-183 (P = 0.001) and miR-375 (P = 0.004). CONCLUSION:miRNA expression patterns in nodal metastases significantly reflect those of the primary tumour in MTC. This further validates previously reported miRNA profile analyses and reiterates the potential significance of miR-9*, -183 and -375 in the pathophysiology of MTC. The possibility of lymph node biopsy miRNA analysis driven clinical decision making may now also be a possibility where conventional techniques are unhelpful.
journal_name
ANZ J Surgjournal_title
ANZ journal of surgeryauthors
Gundara JS,Zhao JT,Gill AJ,Clifton-Bligh R,Robinson BG,Delbridge L,Sidhu SBdoi
10.1111/j.1445-2197.2012.06291.xsubject
Has Abstractpub_date
2014-04-01 00:00:00pages
235-9issue
4eissn
1445-1433issn
1445-2197journal_volume
84pub_type
杂志文章abstract：BACKGROUND:Internal pancreatic fistulas are well recognized complications of chronic pancreatitis. METHODS:Six patients with internal pancreatic fistulas were treated over a period of 5 years from 1995 to 1999. Four patients presented with ascites, one patient presented with ascites and bilateral pleural effusion and ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1046/j.1440-1622.2001.02077.x
更新日期：2001-04-01 00:00:00
abstract：INTRODUCTION:Ludwig's angina (LA) is an uncommon and potentially life-threatening condition of the upper aero-digestive tract that often requires the coordinated efforts of the surgical, anesthetic and intensive care teams to optimize management. The purpose of the present study was to investigate the documented clinic...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2010.05496.x
更新日期：2011-03-01 00:00:00
abstract：BACKGROUND:Gastrointestinal (GI) complications after cardiac surgery are uncommon, but are associated with high morbidity and mortality as well as significant hospital resource utilization. METHODS:We analysed a prospectively collected database containing all adult cardiac surgery procedures performed from July 2001 t...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.12134
更新日期：2013-09-01 00:00:00
abstract：:With the widespread use of abdominal imaging, the detection and therefore incidence of adrenal tumours is increasing. The laparoscopic approach to primary surgical resection of adrenal tumours has now become the standard of care. There is scarce published literature regarding the management and outcomes of recurrent a...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2009.04892.x
更新日期：2009-05-01 00:00:00
abstract：:The article is a summary of some of the pertinent literature on professionalism, highlighting the difference between how physicians understand professionalism and how other groups e.g. politicians, nurses and hospital managers might view the professionalism of doctors. It partly explains why surgeons have become incre...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2008.04822.x
更新日期：2009-03-01 00:00:00
abstract：BACKGROUND:Rural and regional Australia presents a unique challenge in the delivery of surgical services by virtue of its geographical vastness and low population density. While up to 33% of Australians live in rural or regional areas, only 14.8% of surgeons work in a rural or regional area. Data regarding the caseload...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.14680
更新日期：2019-06-01 00:00:00
abstract：BACKGROUND:While recent studies have shown patients with developmental dysplasia of the hip (DDH) undergoing total hip arthroplasty (THA) to achieve comparable post-operative outcomes to patients with primary osteoarthritis (OA), it is unclear whether DDH patients display better or worse preoperative function than the ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2012.06198.x
更新日期：2013-07-01 00:00:00
abstract：BACKGROUND:As pleurodesis causes systemic inflammation and is associated with considerable cost and morbidity during long-term follow up, the identification of patients who will experience an unsuccessful pleurodesis would be desirable. This study was aimed to investigate whether systemic inflammatory reaction induced ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2007.04028.x
更新日期：2007-04-01 00:00:00
abstract：BACKGROUND:Infection with multidrug-resistant (MDR) Gram-negative organisms leads to poorer outcomes in the critically ill burn patient. The aim of this study was to identify the risk factors for MDR Gram-negative pathogen infection in critically ill burn patients admitted to a major tertiary referral intensive care un...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.14144
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:The purpose of the present study was to comprehensively assess the results of surgical management of pelvi-ureteric junction (PUJ) obstruction using lumbotomy as the surgical approach. METHODS:Records of 36 consecutive patients with unilateral PUJ obstruction who underwent pyeloplasty in the last 5 years we...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-1433.2004.03032.x
更新日期：2004-06-01 00:00:00
abstract：BACKGROUND:Improved life-expectancies have seen increased rates of older patients undergoing surgery worldwide. These patients are at increased risk of post-operative complications. Australian evidence is limited regarding the association between age and post-operative outcomes, especially rapid response calls (RRCs) a...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.14433
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:Quad bikes are a prominent cause of morbidity and mortality in Australia in both agriculture and recreation. This study describes the clinical and epidemiological characteristics of quad bike injuries at the Royal Darwin Hospital (RDH). METHODS:A retrospective review of the RDH Trauma Registry for all quad ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15631
更新日期：2020-04-01 00:00:00
abstract：BACKGROUND:Abdominal actinomycosis (AA) is a rare infection. The aim of this study was to summarize the evidence available on AA. METHODS:A systematic review was conducted. Data sources included Trip Database, BIREME, SciELO, Cochrane Library, WoS, MEDLINE, EMBASE, SCOPUS, IBECS and LILACS. Eligibility criteria includ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.16141
更新日期：2020-07-01 00:00:00
abstract：:Adenoid cystic carcinoma of the trachea, although rare, is the second most common primary tumour of the trachea. It is a slow-growing tumour found in younger patients than the more common squamous cell carcinoma and is relatively resistant to treatment, but metastasizes late in the course of disease and even in unrese...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2006.03848.x
更新日期：2006-08-01 00:00:00
abstract：BACKGROUND:The role of minimally invasive major hepatectomy (MIMH) remains controversial and questions remain about its safety and reproducibility outside expert centres. This study examines the changing trends, safety and outcomes associated with the adoption of MIMH based on a contemporary single institution experien...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15563
更新日期：2020-04-01 00:00:00
abstract：INTRODUCTION:Outcomes are reviewed with traumatic brain injury (TBI) involving intracranial haematomata (ICH) with patients in rural and remote areas of South Australia and adjacent states. Patients were referred to the Royal Adelaide Hospital (RAH), a level 1 trauma centre with a major neurosurgical service. METHOD:F...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.13583
更新日期：2017-01-01 00:00:00
abstract：:In his position as curator of the Cowlishaw collection of historical medical books in the Library of the College, Kenneth Russell prepared the definitive catalogue of the collection. This catalogue is comprehensive and for almost all entries there is an annotation that demonstrates his meticulous attention to detail a...
journal_title：ANZ journal of surgery
pub_type： 传,历史文章
doi：10.1046/j.1445-1433.2003.02645.x
更新日期：2003-07-01 00:00:00
abstract：BACKGROUND:Parkland formula (PF) is the most often used schema for calculating intravenous resuscitation fluid requirement in burn patients. Some studies have reported that PF underestimates the fluid requirement in 45-63% of patients. The aim of this retrospective study was to analyse factors influencing first-day int...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2007.04221.x
更新日期：2007-09-01 00:00:00
abstract：BACKGROUND:Patella infera is a known complication of total knee arthroplasty, and the method of soft tissue closure is a possible contributing factor. The aim of our study was to evaluate the effect of knee position during surgical closure of capsule, subcutaneous tissue and skin on patella tendon length after total kn...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.15034
更新日期：2019-03-01 00:00:00
abstract：BACKGROUND:A survey conducted in 1992 found that New Zealand orthopaedic surgeons relied on non-pharmacological methods of deep vein thrombosis prevention in most arthroplasty patients and almost all hip fracture patients. This survey was repeated in 1999 to ascertain whether this pattern of use had changed. METHODS:A...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1046/j.1445-2197.2002.02404.x
更新日期：2002-05-01 00:00:00
abstract：BACKGROUND:Severe tracheal stenosis is a rare life-threatening condition that often requires early surgical intervention. The management of this anomaly has been associated with significant mortality and morbidity. We describe our experience with repair of this condition. METHODS:From 1986 to 2011, 20 patients underwe...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.12132
更新日期：2014-10-01 00:00:00
abstract：BACKGROUND:The aim of this study was to develop a points-based approach to prioritize patients for elective transurethral resection of the prostate and to determine the relative contributions that clinical and psychosocial characteristics should make to a measurement of urgency for surgery. Another objective was to mea...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2006.03988.x
更新日期：2007-03-01 00:00:00
abstract：:Carpal tunnel syndrome is a common condition affecting 1% of the population. Open carpal tunnel release is the most commonly performed procedure for this condition. About 70-90% of patients have good to excellent long-term outcomes with open carpal tunnel release. The remainder have poor outcomes. An understanding of ...
journal_title：ANZ journal of surgery
pub_type： 杂志文章,评审
doi：10.1111/j.1445-2197.2009.05175.x
更新日期：2010-01-01 00:00:00
abstract：BACKGROUND:Hepatic haemangiomas are congenital vascular malformations. They are the most common benign tumours of the liver and are often asymptomatic. Spontaneous or traumatic rupture, intratumoral bleeding, consumption coagulopathy and rapid growth are the mandatory surgical indications. We present our experience ove...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/j.1445-2197.2006.03869.x
更新日期：2006-09-01 00:00:00
abstract：BACKGROUND:A reversal of Hartmann's procedure can be performed using either a laparoscopic or open approach. However, laparoscopic reversal (LR) of Hartmann's procedure is challenging. This study was designed to compare the results between open and laparoscopic approaches. METHODS:This was a retrospective study of pro...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.13979
更新日期：2018-05-01 00:00:00
abstract：BACKGROUND:This study is a collation of baseline demographic characteristics of those presenting for rotator cuff repair in New Zealand, and exploration of associations with preoperative function and pain. Data were obtained from the New Zealand Rotator Cuff Registry; a multicentre, nationwide prospective cohort of rot...
journal_title：ANZ journal of surgery
pub_type： 杂志文章,多中心研究
doi：10.1111/ans.13921
更新日期：2017-09-01 00:00:00
abstract：BACKGROUND:To ascertain if post-operative drain fluid lipase is superior to amylase in routinely detecting clinically significant post-operative pancreatic fistulae (POPF). METHOD:Between January 2015 and March 2016 data were collected on all patients undergoing pancreatic surgery at a regional referral centre. Routin...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.14266
更新日期：2018-06-07 00:00:00
abstract：:Chronic constipation is a common condition in both adults and children. Children with chronic constipation frequently have symptoms that continue into adulthood. In the second part of the review we describe advances in the identification of abnormalities in the control of motility. The role of neurotransmitters in bot...
journal_title：ANZ journal of surgery
pub_type： 杂志文章,评审
doi：10.1111/j.1445-1433.2004.03202.x
更新日期：2004-10-01 00:00:00
abstract：BACKGROUND:Dermatofibrosarcoma protuberans (DFSP) is a rare locally advanced soft-tissue tumour that is often misdiagnosed at presentation, resulting in inadequate initial resection, requiring multiple resections and reconstructive procedures. We reviewed our experience and treatment outcomes with this tumour and propo...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1111/ans.13276
更新日期：2016-05-01 00:00:00
abstract：BACKGROUND:There are many clinical situations in which immune suppression or deficiency occurs. This may lead to healing impairment. The aim of the present study was to characterize the effect of T lymphocyte deficiency on wound healing, and on -platelet-derived growth factor (PDGF), bFGF (basic fibroblast growth facto...
journal_title：ANZ journal of surgery
pub_type： 杂志文章
doi：10.1046/j.1445-2197.2002.02424.x
更新日期：2002-07-01 00:00:00
