Rotavirus genotypes in Malaysia and universal rotavirus vaccination.

Abstract:

:Group A rotavirus (RV-A) genotypes isolated in Malaysia was studied to estimate the effectiveness of a universal RV-A vaccination in Malaysia. A simple mathematical model was used, with input from a two-year, two-center, prospective study on hospitalization of RV-A gastroenteritis (RVGE) in young children, published data on RV-A hospitalizations and genotypes, mortality on childhood GE and published genotype-specific efficacy data on two RV-A vaccines. Assuming a 95% vaccine coverage, the overall projected effectiveness was 75.7 to 88.1% for Rotateq and 78.7 to 90.6% for Rotarix® against RVGE-related hospitalizations. The projected annual reduction in RVGE-related deaths was 27 to 32 deaths (from 34 deaths) for Rotateq and 28 to 32 deaths annually for Rotarix. A universal RV-A vaccine is efficacious in reducing RVGE-related hospitalizations and mortality in Malaysia.

journal_name

Hum Vaccin Immunother

authors

Lee WS,Lim BT,Chai PF,Kirkwood CD,Lee JK

doi

10.4161/hv.21577

subject

Has Abstract

pub_date

2012-10-01 00:00:00

pages

1401-6

issue

10

eissn

2164-5515

issn

2164-554X

pii

21577

journal_volume

8

pub_type

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