Abstract:
:The α-glucosidase inhibitory activities of bergenin derivatives were evaluated. Bergenin derivatives were synthesized from bergenin which is a characteristic compound of B. ligulata. A new bergenin derivative, 11-O-(3',4'-dimethoxybenzoyl)-bergenin showed the highest potent inhibitory activity among those of bergenin derivatives. The presence of substituents at 3',4'-position in bergenin derivatives altered the α-glucosidase inhibitory activity. 11-O-(3',4'-dimethoxybenzoyl)-bergenin was noncompetitive inhibitor for α-glucosidase. The present study reveals that bergenin derivatives could be classified as a new group of α-glucosidase inhibitors.
journal_name
J Enzyme Inhib Med Chemjournal_title
Journal of enzyme inhibition and medicinal chemistryauthors
Kashima Y,Yamaki H,Suzuki T,Miyazawa Mdoi
10.3109/14756366.2012.719503subject
Has Abstractpub_date
2013-12-01 00:00:00pages
1162-70issue
6eissn
1475-6366issn
1475-6374journal_volume
28pub_type
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journal_title:Journal of enzyme inhibition and medicinal chemistry
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