Abstract：
:Cold atmospheric plasma (CAP), a technology based on quasi-neutral ionized gas at low temperatures, is currently being evaluated as a new highly selective alternative addition to existing cancer therapies. Here, we present a first attempt to identify the mechanism of CAP action. CAP induced a robust ~2-fold G2/M increase in two different types of cancer cells with different degrees of tumorigenicity. We hypothesize that the increased sensitivity of cancer cells to CAP treatment is caused by differences in the distribution of cancer cells and normal cells within the cell cycle. The expression of γH2A.X (pSer139), an oxidative stress reporter indicating S-phase damage, is enhanced specifically within CAP treated cells in the S phase of the cell cycle. Together with a significant decrease in EdU-incorporation after CAP, these data suggest that tumorigenic cancer cells are more susceptible to CAP treatment.
journal_name
Sci Repjournal_title
Scientific reportsauthors
Volotskova O,Hawley TS,Stepp MA,Keidar Mdoi
10.1038/srep00636subject
Has Abstractpub_date
2012-01-01 00:00:00pages
636issn
2045-2322journal_volume
2pub_type
杂志文章abstract：:Aberrant restoration of AR activity is linked with prostate tumor growth, therapeutic failures and development of castrate-resistant prostate cancer. Understanding the processes leading to AR-reactivation should provide the foundation for novel avenues of drug discovery. A differential gene expression study was conduc...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-10068-9
更新日期：2017-08-29 00:00:00
abstract：:Activation of the inflammasome is involved in the progression of retinal degenerative diseases, in particular, in the pathogenesis of Age-Related Macular Degeneration (AMD), with NLRP3 activation the focus of many investigations. In this study, we used genetic and pharmacological approaches to explore the role of the ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58849-z
更新日期：2020-02-10 00:00:00
abstract：:From the viewpoint of networks, a ranking system for players or teams in sports is equivalent to a centrality measure for sports networks, whereby a directed link represents the result of a single game. Previously proposed network-based ranking systems are derived from static networks, i.e., aggregation of the results...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep00904
更新日期：2012-01-01 00:00:00
abstract：:CD40 ligand (CD40L), a member of the tumor necrosis factor (TNF) superfamily, binds to CD40, leading to many effects depending on target cell type. Platelets express CD40L and are a major source of soluble CD40L. CD40L has been shown to potentiate platelet activation and thrombus formation, involving both CD40-depende...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-17189-1
更新日期：2017-12-07 00:00:00
abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...
journal_title：Scientific reports
pub_type： 已发布勘误
doi：10.1038/s41598-019-54657-2
更新日期：2019-11-25 00:00:00
abstract：:While TLR-activated pathways are key regulators of B cell responses in mammals, their impact on teleost B cells are scarcely addressed. Here, the potential of Atlantic salmon B cells to respond to TLR ligands was shown by demonstrating a constitutive expression of nucleic-acid sensing TLRs in magnetic sorted IgM+ cell...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-21895-9
更新日期：2018-02-23 00:00:00
abstract：:Many human introns carry out a function, in the sense that they are critical to maintain normal cellular activity. Their identification is fundamental to understanding cellular processes and disease. However, being noncoding elements, such functional introns are poorly predicted based on traditional approaches of sequ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-04476-0
更新日期：2017-06-23 00:00:00
abstract：:Older adults living in remote areas with limited access to health services are at higher risk to develop visual impairment and blindness. We conducted a population-based survey to determine the vision status in subjects 45 years of age and older from urban and rural areas of Parintins city, Brazilian Amazon Region. Pa...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-19338-6
更新日期：2018-01-17 00:00:00
abstract：:Surface-enhanced Raman spectroscopy (SERS) is considered a highly promising technology for different analytical purposes. The applications of SERS are still quite limited due its relatively poor quantitative repeatability and the fact that SERS is very sensitive to oxidation, which is a challenge especially with silve...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep37192
更新日期：2016-11-16 00:00:00
abstract：:Receptor trafficking is pivotal for the temporal and spatial control of GPCR signaling and is regulated by multiple cellular proteins. We provide evidence that GPCRs interact with 14-3-3 signal adaptor/scaffold proteins and that this interaction regulates receptor trafficking in two ways. We found GPCR/14-3-3 interact...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-47478-w
更新日期：2019-08-01 00:00:00
abstract：:A new species of fossil conifer wood, Podocarpoxylon donghuaiense sp. nov., is described from the late Eocene of Nadu Formation in Baise Basin of the Guangxi Province, South China. This fossil wood is characterized by distinct growth rings, circular to oval tracheids in cross section, 1-2-seriate opposite pits on radi...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep32294
更新日期：2016-08-30 00:00:00
abstract：:For understanding the quantitative effect of nonhydrostatic stress on properties of material, the crystal structure and Raman spectra of 3C-SiC under hydrostatic and nonhydrostatic stress were calculated using a first-principles method. The results show that the lattice constants (a, b, and c) under nonhydrostatic str...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-018-29666-2
更新日期：2018-07-26 00:00:00
abstract：:Angiotensin-converting enzyme (ACE) is an evolutionarily conserved peptidyl dipeptidase. Mammalian ACE converts angiotensin I to the active vasoconstrictor angiotensin II, thus playing a critical role for homeostasis of the renin-angiotensin system. In Drosophila, the ACE homolog Ance is expressed in specific regions ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13487-w
更新日期：2017-10-13 00:00:00
abstract：:Uropathogenic strains of Escherichia coli establish urinary tract infections by attaching to host epithelial cells using adhesive organelles called fimbriae. Fimbriae are helix-like structures with a remarkable adaptability, offering safeguarding for bacteria exposed to changing fluid forces in the urinary tract. We c...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep03393
更新日期：2013-12-02 00:00:00
abstract：:In this paper we present a contactless transient carrier spectroscopy and imaging technique for traps in silicon. At each pixel, we fit the transient decay of the trap emission which allows us to obtain both the trap time constant and trap concentration. Here we show that this technique allows for high-resolution imag...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-49804-8
更新日期：2019-10-03 00:00:00
abstract：:Ultrasound imaging is affected by coherent noise or speckle, which reduces contrast and overall image quality and degrades the diagnostic precision of the collected images. Elevational angular compounding (EAC) is an attractive means of addressing this limitation, since it reduces speckle noise while operating in real...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-75092-8
更新日期：2020-10-23 00:00:00
abstract：:Applying a circular economy approach, this research explores the use of cheese whey permeate (CWP), by-product of whey ultrafiltration, as cheap substrate for the production of bacterial cellulose (BC) and Sakacin-A, to be used in an antimicrobial packaging material. BC from the acetic acid bacterium Komagataeibacter ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-78430-y
更新日期：2020-12-07 00:00:00
abstract：:Biochemical remission after transsphenoidal surgery is still unsatisfied in acromegaly patients with macroadenomas, especially with invasive macroadenomas. Concerning the impact of preoperative somatostatin analogues (SSAs) on surgical outcomes, previous studies with limited cases reported conflicting results. To asse...
journal_title：Scientific reports
pub_type： 杂志文章,meta分析
doi：10.1038/s41598-019-50639-6
更新日期：2019-10-01 00:00:00
abstract：:Silver-based antibacterial agents have obtained wide attention due to the fact that bacteria in the environment is ubiquitous, which has become one of the most difficult problems for human health. However, the antibacterial mechanism and process are still inconclusive. Here, Ag2O nanoparticles (NPs) with uniform spher...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-021-81305-5
更新日期：2021-01-18 00:00:00
abstract：:We introduce an experimental method based upon a glass micropipette microinjection technique for generating a multitude of interconnected vesicles (IVs) in the interior of a single giant unilamellar phospholipid vesicle (GUV) serving as a cell model system. The GUV membrane, consisting of a mixture of soybean polar li...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-70562-5
更新日期：2020-08-20 00:00:00
abstract：:A correction to this article has been published and is linked from the HTML version of this paper. The error has been fixed in the paper. ...
journal_title：Scientific reports
pub_type： 杂志文章,已发布勘误
doi：10.1038/s41598-017-17040-7
更新日期：2017-12-05 00:00:00
abstract：:Switching magnetizations with femtosecond circularly polarized lasers may have revolutionary impacts on magnetic data storage and relevant applications. Achievements in ferrimagnetic and ferromagnetic materials of various structures strongly imply a general phenomenon of fundamental atom-laser interaction. Rotating an...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep41294
更新日期：2017-01-24 00:00:00
abstract：:Adherence to cardioprotective medications following myocardial infarction (MI) is commonly assessed using a binary threshold of 80%. We investigated the relationship between medication adherence as a continuous measure and outcomes in MI survivors using restricted cubic splines (RCS). We identified all patients aged ≥...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-60799-5
更新日期：2020-03-09 00:00:00
abstract：:Electrophysiological recordings in cortex in vivo have revealed a rich variety of dynamical regimes ranging from irregular asynchronous states to a diversity of synchronized states, depending on species, anesthesia, and external stimulation. The average population firing rate in these states is typically low. We study...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-12033-y
更新日期：2017-09-20 00:00:00
abstract：:Nile tilapia (Oreochromis niloticus) is a globally significant aquaculture species rapidly gaining status as a farmed commodity. In West Africa, wild Nile tilapia genetic resources are abundant yet knowledge of fine-scale population structure and patterns of natural genetic variation are limited. Coinciding with this ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-019-53295-y
更新日期：2019-11-14 00:00:00
abstract：:Increasing grain zinc (Zn) concentration of cereals for minimizing Zn malnutrition in two billion people represents an important global humanitarian challenge. Grain Zn in field-grown wheat at the global scale ranges from 20.4 to 30.5 mg kg-1, showing a solid gap to the biofortification target for human health (40 mg ...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-07484-2
更新日期：2017-08-01 00:00:00
abstract：:RNA-based three-way junctions (3WJs) are naturally occurring structures found in many functional RNA molecules including rRNA, tRNA, snRNA and ribozymes. 3WJs are typically characterized as resulting from an RNA molecule folding back on itself in cis but could also form in trans when one RNA, for instance a microRNA b...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep45393
更新日期：2017-03-28 00:00:00
abstract：:Plasmodiophora brassicae causes clubroot disease in cruciferous. In this report, lipid droplets were observed in the resting spores of P. brassicae. 295 lipid droplet-associated proteins were identified and categorized into nine groups. Transcriptome analysis of these proteins during three different zoosporic stages r...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/srep36965
更新日期：2016-11-22 00:00:00
abstract：:On-surface reactions based on Ullmann coupling are known to proceed on coinage-metal substrates (e.g. Au, Ag, Cu), with the chemistry of the surface strongly influencing the reaction progression. In addition, the topography of the surface may be expected to affect the local adsorption geometry of the reactants as well...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-017-13315-1
更新日期：2017-11-06 00:00:00
abstract：:The Lesotho guidelines for the management of drug-resistant tuberculosis (TB) recommend initiation of patients diagnosed with rifampicin resistant (RR)-TB on a standardized drug resistant regimen while awaiting confirmation of rifampicin resistant TB (RR-TB) and complete drug susceptibility test results. Review of dia...
journal_title：Scientific reports
pub_type： 杂志文章
doi：10.1038/s41598-020-58690-4
更新日期：2020-02-05 00:00:00
