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Micronization of taxifolin by supercritical antisolvent process and evaluation of radical scavenging activity.

Abstract：

:The aim of this study was to prepare micronized taxifolin powder using the supercritical antisolvent precipitation process to improve the dissolution rate of taxifolin. Ethanol was used as solvent and carbon dioxide was used as an antisolvent. The effects of process parameters, such as temperature (35-65 °C), pressure (10-25 MPa), solution flow rate (3-6 mL/min) and concentration of the liquid solution (5-20 mg/mL) on the precipitate crystals were investigated. With a lower temperature, a stronger pressure and a lower concentration of the liquid solution, the size of crystals decreased. The precipitation temperature, pressure and concentration of taxifolin solution had a significant effect. However, the solution flow rate had a negligible effect. It was concluded that the physicochemical properties and dissolution rate of crystalline taxifolin could be improved by physical modification such as particle size reduction using the supercritical antisolvent (SAS) process. Further, the SAS process was a powerful methodology for improving the physicochemical properties and radical scavenging activity of taxifolin.

journal_name

Int J Mol Sci

journal_title

International journal of molecular sciences

authors

Zu S,Yang L,Huang J,Ma C,Wang W,Zhao C,Zu Y

doi

10.3390/ijms13078869

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

8869-81

issue

7

issn

1422-0067

pii

ijms-13-08869

journal_volume

13

pub_type

杂志文章

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