Abstract:
:The 'at-risk' criteria are a useful paradigm for investigating the psychological, neurocognitive, neurobiological and genetic risk factors for psychosis, specifically schizophrenia. To date, the primary outcome of interest in at-risk research has been the development of psychotic disorder, whereby patients are categorized as either having 'transitioned' or 'not transitioned'. Despite the acceptance of this dichotomy, it is important to consider that the threshold at which psychotic symptoms progress from attenuated to frank 'psychotic disorder' is arbitrary and may be incorrect or meaningless in terms of neurobiological and functional changes associated with psychosis. This has implications for clinical care and the search for markers of schizophrenia. We present recent research suggesting that the term 'outcome' needs to be broadened to incorporate non-psychotic diagnoses, functioning and negative symptoms. Shifting the traditional notion of outcome is the future challenge for at-risk research, but the inclusion of outcomes other than psychosis is likely to result in better aetiological models of psychotic illness.
journal_name
Epidemiol Psychiatr Scijournal_title
Epidemiology and psychiatric sciencesauthors
Lin A,Nelson B,Yung ARdoi
10.1017/S2045796012000388subject
Has Abstractpub_date
2012-12-01 00:00:00pages
329-34issue
4eissn
2045-7960issn
2045-7979pii
S2045796012000388journal_volume
21pub_type
社论abstract::The principle of pragmatism in clinical trials has been broadly recognised as a way to close the gap between research and practice. In this contribution, we argue that the conduct of pragmatic clinical trials in Europe may be hampered by poor implementation of current European Union's Clinical Trial Regulation No. 536...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796020000396
更新日期:2020-05-06 00:00:00
abstract::Aims. Little is known about how the rates and characteristics of mental health service users in unpaid work, training and study compare with those in paid employment. Methods. From staff report and patient records, 1353 mental health service users of seven Community Mental Health Teams in two London boroughs were cate...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796012000534
更新日期:2013-06-01 00:00:00
abstract:AIMS:Establishing the minimum clinically important difference (MCID) in functioning and cognition is essential to the interpretation of the research and clinical work conducted in bipolar disorders (BD). The present study aimed to estimate the MCID for the Functioning Assessment Short Test (FAST) and a battery of neuro...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796020000566
更新日期:2020-07-20 00:00:00
abstract::Aims. Prevalence and covariates of subclinical psychosis have gained increased interest in the context of early identification and treatment of persons at risk for psychosis. Methods. We analysed 9829 adults representative of the general population within the canton of Zurich, Switzerland. Two psychosis syndromes, der...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796013000681
更新日期:2015-02-01 00:00:00
abstract::Aims. High numbers of psychiatric service users experience domestic violence, yet limited interventions exist for these victims. We piloted a domestic violence intervention for community mental health services to explore the feasibility of a future cluster randomized controlled trial. Methods. Quasi-experimental contr...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796013000206
更新日期:2014-03-01 00:00:00
abstract::A recent meta-analysis of antidepressant trials is the largest conducted to date. Although it claims to prove antidepressant effectiveness beyond dispute, the main outcome is response rates, which are derived from continuous data in a process that can inflate differences between groups. The standardised mean differenc...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796018000240
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Studies in urban areas identified environmental risk factors for mental illness, but little research on this topic has been performed in rural areas. METHODS:Hospital admission rates were computed for 174 rural municipalities in the catchment area of the state psychiatric hospital in Günzburg in years 2006 ...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796012000157
更新日期:2012-12-01 00:00:00
abstract:BACKGROUND:Population-based studies have identified that delusional-like experiences (DLEs) are common in the general population. While there is a large literature exploring the relationship between poor social support and risk of mental illness, there is a lack of empirical data examining the association of poor socia...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796011000862
更新日期:2012-06-01 00:00:00
abstract:AIMS:First-episode psychosis (FEP) is a major life event and can have an adverse impact on the diagnosed individual and their families. The importance of intervening early and providing optimal treatments is widely acknowledged. In comparison to patient groups, literature is scarce on identifying treatment predictors a...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章,多中心研究,随机对照试验
doi:10.1017/S2045796019000155
更新日期:2019-04-10 00:00:00
abstract:AIMS:To explore the role of psychiatric admission, diagnosis and reported unfair treatment in the relationship between ethnicity and mistrust of mental health services. METHODS:The Mental Illness-Related Investigations on Discrimination (MIRIAD) study was a cross-sectional study of 202 individuals using secondary ment...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796014000158
更新日期:2015-06-01 00:00:00
abstract::Understanding the excess risk of psychotic disorders in migrant and ethnic minority groups has long been an important research focus in psychiatric epidemiology and public mental health. Heterogeneity between migrant groups based on the region of origin, minority status and other socioeconomic factors may provide clue...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796018000501
更新日期:2019-04-01 00:00:00
abstract::Psychiatry is in one of its regular crises. It is a crisis of its diagnostic systems despite - perhaps because - of the recurrent claims about the extent of diagnosable 'brain disorders'. It is a crisis of its explanatory systems despite - perhaps because - of its current wager on the brain as the ultimate locus for e...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796015000621
更新日期:2016-04-01 00:00:00
abstract::Randomized controlled trials (RCTs), typically, randomize participants to one of two intervention groups. It has been shown, however, that about 25% of RCTs published in the scientific literature randomize participants to three or more treatment groups. These studies are called 'multi-arm' trials: there may be, for in...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796013000231
更新日期:2013-09-01 00:00:00
abstract::Autism spectrum disorder (ASD) is a neurodevelopmental disorder mainly characterised by deficits in social communication as well as by narrow patterns of behaviour and interests (American Psychiatric Association, 2013), often accompanied by language, intellectual and sensory impairments. The severity of these impairme...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796017000610
更新日期:2018-04-01 00:00:00
abstract::Lately on these pages, a discussion is going on over the opportunity of the use of the definition 'outsider'. Especially in the USA, it is judged as demeaning, discriminating and inappropriate, whilst in Europe, it is used in a much more unconcerned way. Mr Gioni curator of numerous international exhibitions including...
journal_title:Epidemiology and psychiatric sciences
pub_type: 传,历史文章,杂志文章
doi:10.1017/S2045796018000550
更新日期:2018-12-01 00:00:00
abstract:AIMS:There is currently no gold-standard definition or method for identifying suicide clusters, resulting in considerable heterogeneity in the types of suicide clusters that are detected. This study sought to identify the characteristics, mechanisms and parameters of suicide clusters using three cluster detection metho...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796020000645
更新日期:2020-08-06 00:00:00
abstract:AIMS:Research demonstrates elevated levels of common mental disorders among Syrian refugees, but the majority of studies have, to date, focused on adult populations. This study aims to estimate the prevalence of depression, anxiety and post-traumatic stress disorder (PTSD) among Syrian children and adolescents living i...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796020001079
更新日期:2020-12-10 00:00:00
abstract:AIM:Previous work suggests that the Dutch variant of assertive community treatment (ACT), known as Function ACT (FACT), may be effective in increasing symptomatic remission rates when replacing a system of hospital-based care and separate community-based facilities. FACT guidelines propose a different pattern of psychi...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/s2045796011000369
更新日期:2011-09-01 00:00:00
abstract::Mental health care in the second half of the 20th century in much of the developed world has been dominated by the move out from large asylums. Both in response to this move and to make it possible, a pattern of care has evolved which is most commonly referred to as 'Community Psychiatry'. This narrative review descri...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796014000560
更新日期:2014-12-01 00:00:00
abstract::Psychiatry is having a great time. Over the last few years, we have seen an exceptional explosion in neuroscience knowledge, and especially in our understanding of the molecular mechanisms through which environmental and genetic factors affect the brain and regulate behaviour, while at the same interacting with periph...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S204579601500089X
更新日期:2016-04-01 00:00:00
abstract::When developing accessible, affordable and effective mental health systems, exchange of data between countries is an important moving force towards better mental health care. Unfortunately, health information systems in most countries are weak in the field of mental health, and comparability of data is low. Special in...
journal_title:Epidemiology and psychiatric sciences
pub_type: 社论
doi:10.1017/s2045796011000060
更新日期:2011-03-01 00:00:00
abstract:AIMS:Suicidal behaviour is prevalent among adolescents and is a significant predictor of future suicide attempts (SAs) and suicide death. Data on the prevalence and epidemiological characteristics of suicidal behaviour in Chinese adolescents are limited. This study was aimed to examine the prevalence, characteristics a...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796017000488
更新日期:2019-06-01 00:00:00
abstract::Background. Interest in features of our local environments that may promote better mental health and wellbeing continues to rise among decision makers. Our purpose was to highlight a selection of these challenges and some promising avenues for enhancing the quality of evidence. Method. An analysis of approximately 267...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S204579601400050X
更新日期:2015-02-01 00:00:00
abstract::The relationship between poverty and mental health is indisputable. However, to have an influence on the next set of sustainable global development goals, we need to understand the causal relationships between social determinants such as poverty, inequality, lack of education and unemployment; thereby clarifying which...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796015000086
更新日期:2015-04-01 00:00:00
abstract::Names matter! Schizophrenia has negative associations which impede individual recovery and induce societal and self-stigmatization. Alternatives have been proposed and are worthy of debate; changes made in Japan have generally been considered successful. The group of 'schizophrenia and other psychoses' could be furthe...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796013000486
更新日期:2013-12-01 00:00:00
abstract::Aims. To assess the breadth of mental and substance coverage in the Cochrane review system. Methods. All mental health and substance entries were identified from the 2005 to April 2012 Cochrane Database of Systematic Reviews. Results. A total of 1019 entries focused on mental health or substance misuse, with 698 (68.5...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章,评审
doi:10.1017/S2045796012000455
更新日期:2013-06-01 00:00:00
abstract::Aims Social workers report high levels of stress and have an increased risk for hospitalisation with mental diagnoses. However, it is not known whether the risk of work disability with mental diagnoses is higher among social workers compared with other human service professionals. We analysed trends in work disability...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796016000597
更新日期:2017-12-01 00:00:00
abstract:AIMS:Childhood maltreatment and a family history of a schizophrenia spectrum disorder (SSD) are each associated with social-emotional dysfunction in childhood. Both are also strong risk factors for adult SSDs, and social-emotional dysfunction in childhood may be an antecedent of these disorders. We used data from a lar...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S204579601600055X
更新日期:2017-12-01 00:00:00
abstract:AIM:To determine whether disparities exist in mental health care provision to immigrants and Italian citizens with severe mental illness in Bologna, Italy. METHODS:Records of prevalent cases on 31/12/2010 with severe mental illness and ≥1 contact with Community Mental Health Centers in 2011 were extracted from the men...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章
doi:10.1017/S2045796014000250
更新日期:2015-08-01 00:00:00
abstract::Depression in the elderly is common and exhibits a distinctive phenomenology, due to neurobiological, physiological, psychological and social changes related to ageing. Most elderly with depression are managed in primary health care. Although the number of scientific publications related to geriatric psychiatry has in...
journal_title:Epidemiology and psychiatric sciences
pub_type: 杂志文章,评审
doi:10.1017/S204579601200025X
更新日期:2012-09-01 00:00:00