Efficacy of Solifenacin on Irritable Bowel Syndrome With Diarrhea: Open-label Prospective Pilot Trial.

abstract：BACKGROUND/AIMS:Several motility disorders are associated with disruption of interstitial cells of Cajal (ICC), which provide important functions, such as pacemaker activity, mediation of neural inputs and responses to stretch in the gastrointestinal (GI) tract. Restoration of ICC networks may be therapeutic for GI mot...

journal_title：Journal of neurogastroenterology and motility

authors： McCann CJ,Hwang SJ,Hennig GW,Ward SM,Sanders KM

更新日期：2014-07-31 00:00:00

abstract：Background/Aims:Self-reported lactose intolerance (LI) is frequent in patients with functional bowel disorders (FBD) that could be interpreted as irritable bowel syndrome (IBS). The present study aims to characterize the responses of FBD patients without small intestinal bacterial overgrowth (SIBO), and LI, in terms of...

journal_title：Journal of neurogastroenterology and motility

authors： Bouchoucha M,Fysekidis M,Rompteaux P,Raynaud JJ,Sabate JM,Benamouzig R

更新日期：2020-12-28 00:00:00

abstract：:Gastroesophageal reflux disease (GERD) is a very common disease, and the prevalence in the general population has recently increased. GERD is a chronic relapsing disease associated with motility disorders of the upper gastrointestinal tract. Several factors are implicated in GERD, including hypotensive lower esophagea...

journal_title：Journal of neurogastroenterology and motility

authors： Lin S,Li H,Fang X

更新日期：2019-10-30 00:00:00

abstract：BACKGROUND/AIMS:To evaluate the effects of the phosphodiesterase type 5 (PDE5) inhibitor vardenafil on esophageal function, including bolus transit, using multichannel intraluminal impedance and esophageal manometry (MII-EM). METHODS:Sixteen healthy volunteers (15 men) underwent an MII-EM study including 10 liquid swa...

journal_title：Journal of neurogastroenterology and motility

authors： Lee TH,Lee JS,Hong SJ,Jeon SR,Kim WJ,Kim HG,Cho JY,Kim JO

更新日期：2012-10-01 00:00:00

abstract：BACKGROUND/AIMS:Rats with a spontaneous null mutation in endothelin receptor type B or Ednrb (sl/sl; spotting lethal) lack enteric neurons in the distal bowel and usually die within the first week after birth. This early postnatal lethality limits their use for examining the potential of cell therapy to treat Hirschspr...

journal_title：Journal of neurogastroenterology and motility

authors： Stamp LA,Obermayr F,Pontell L,Young HM,Xie D,Croaker DH,Song ZM,Furness JB

更新日期：2015-10-01 00:00:00

abstract：:That gastrointestinal motility can influence the gut microbiota has been known for decades and the clinical consequences of impaired motility, in terms of the bacterial population of the small intestine, amply illustrated by the syndrome of small intestinal bacterial overgrowth which so commonly accompanies diffuse in...

journal_title：Journal of neurogastroenterology and motility

authors： Quigley EM

更新日期：2011-04-01 00:00:00

abstract：BACKGROUND/AIMS:Despite numerous studies on the relation of genetic polymorphisms with irritable bowel syndrome (IBS), the results still remain inconclusive. The aim of this study was to assess the possible association between SLC6A4 serotonin transporter gene linked polymorphic region (5-HTTLPR), ADRA2A -1291C>G, GNB3...

journal_title：Journal of neurogastroenterology and motility

authors： Choi YJ,Hwang SW,Kim N,Park JH,Oh JC,Lee DH

更新日期：2014-07-31 00:00:00

abstract：:Live imaging has become an essential tool to investigate the coordinated activity and output of cellular networks. Within the last decade, 2 Nobel prizes have been awarded to recognize innovations in the field of imaging: one for the discovery, use, and optimization of the green fluorescent protein (2008) and the seco...

journal_title：Journal of neurogastroenterology and motility

authors： Boesmans W,Hao MM,Vanden Berghe P

更新日期：2015-07-30 00:00:00

abstract：BACKGROUND/AIMS:In isolated guinea-pig colon, we investigated regional differences in peristalsis evoked by intrinsic electrical nerve stimulation. METHODS:Four colonic segments from mid and distal colon of Hartley guinea pigs, were mounted horizontally in an organ bath. Measurement of pellet propulsion time, intralum...

journal_title：Journal of neurogastroenterology and motility

authors： Kwak JM,Babygirija R,Gribovskaja-Rupp I,Takahashi T,Yamato S,Ludwig K

更新日期：2013-04-01 00:00:00

abstract：BACKGROUND/AIMS:Gastroparesis-like syndrome (GLS) is defined as gastroparesis-like symptoms with normal gastric scintigraphy. While the efficacy of gastric electrical stimulation (GES) in gastroparesis is well known, the utility of GES in GLS is largely unknown. Our aim was to clarify the role of GES in GLS. We implant...

journal_title：Journal of neurogastroenterology and motility

authors： Singh S,McCrary J,Kedar A,Weeks S,Beauerle B,Weeks A,Endashaw O,Lahr C,Starkebaum W,Abell T

更新日期：2015-10-01 00:00:00

abstract：Background/Aims:Since the use of dexlansoprazole in Asian subjects with gastroesophageal reflux disease (GERD) has not been adequately characterized, this study was conducted to evaluate the efficacy and safety of dexlansoprazole modified-release in Asian subjects with non-erosive reflux disease (NERD) and erosive esop...

journal_title：Journal of neurogastroenterology and motility

authors： Wu JCY,Sheu BS,Wu MS,Lee YC,Choi MG

更新日期：2020-01-30 00:00:00

abstract：:The mammalian intestine contains many different cell types but is comprised of 2 main cell types: epithelial cells and smooth muscle cells. Recent in vivo and in vitro evidence has revealed that various alterations to the DNA methylation apparatus within both of these cell types can result in a variety of cellular phe...

journal_title：Journal of neurogastroenterology and motility

authors： Jorgensen BG,Ro S

更新日期：2019-07-01 00:00:00

abstract：BACKGROUND/AIMS:Recent studies reveal that acute gastroenteritis can precipitate irritable bowel syndrome (IBS) symptoms leading to the concept of post-infectious IBS. However, the overall contribution of gastroenteritis to the total IBS prevalence is unknown. In this exercise we try to estimate the contribution of gas...

journal_title：Journal of neurogastroenterology and motility

authors： Shah ED,Riddle MS,Chang C,Pimentel M

更新日期：2012-04-01 00:00:00

abstract：:In predisposed individuals with long standing gastroesophageal reflux disease (GERD), esophageal squamous mucosa can transform into columnar mucosa with intestinal metaplasia, commonly called Barrett's esophagus (BE). Barrett's mucosa can develop dysplasia, which can be a precursor for esophageal adenocarcinoma (EAC)....

journal_title：Journal of neurogastroenterology and motility

authors： Patel A,Gyawali CP

更新日期：2019-04-30 00:00:00

abstract：Background/Aims:Current evidence suggests the presence of motility or functional abnormalities in one area of the gastrointestinal tract increases the likelihood of abnormalities in others. However, the relationship of gastroparesis to chronic constipation (slow transit constipation and dyssynergic defecation) has been...

journal_title：Journal of neurogastroenterology and motility

authors： Zikos TA,Kamal AN,Neshatian L,Triadafilopoulos G,Clarke JO,Nandwani M,Nguyen LA

更新日期：2019-04-30 00:00:00

abstract：:This article highlights the role of prucalopride in the management of chronic constipation based upon the principles of meta-analysis using data reported in the published randomized, controlled trials. Sixteen randomized, controlled trials on 3943 patients reported the effectiveness of prucalopride in patients with ch...

journal_title：Journal of neurogastroenterology and motility

authors： Sajid MS,Hebbar M,Baig MK,Li A,Philipose Z

更新日期：2016-07-30 00:00:00

abstract：:Visceral pain is the most common form of pain caused by varied diseases and a major reason for patients to seek medical consultation. It also leads to a significant economic burden due to workdays lost and reduced productivity. Further, long-term use of non-specific medications is also associated with side effects aff...

journal_title：Journal of neurogastroenterology and motility

authors： Kannampalli P,Sengupta JN

更新日期：2015-03-30 00:00:00

abstract：BACKGROUND/AIMS:Irritable bowel syndrome (IBS) is one of the most frequently observed disorders by primary care and practitioners. The aim of this study was to estimate the prevalence of IBS using the Rome II and III criteria in the general Korean population and also to compare sociodemographic differences between subj...

journal_title：Journal of neurogastroenterology and motility

authors： Park DW,Lee OY,Shim SG,Jun DW,Lee KN,Kim HY,Lee HL,Yoon BC,Choi HS

更新日期：2010-04-01 00:00:00

abstract：Background/Aims:Integrated relaxation pressure (IRP) is defined as the average minimum esophagogastric junction (EGJ) pressure for 4 seconds of relaxation (contiguous or noncontiguous) within 10 seconds of swallowing. The durability of IRP values during successive swallows in the supine position remains to be elucidate...

journal_title：Journal of neurogastroenterology and motility

authors： Elangovan A,Shibli F,Fass R

更新日期：2021-01-28 00:00:00

abstract：:Assessment of transit through the gastrointestinal tract provides useful information regarding gut physiology and patho-physiology. Although several methods are available, each has distinct advantages and limitations. Recently, an ingestible wire-less motility capsule (WMC), similar to capsule video endoscopy, has bec...

journal_title：Journal of neurogastroenterology and motility

authors： Lee YY,Erdogan A,Rao SS

更新日期：2014-04-30 00:00:00

abstract：Background/Aims:Probiotics are expected to modify the composition of gut microbiota. We aimed to investigate the changes in the composition and diversity of gut microbiota by the administration of probiotics in healthy individuals. Methods:Twelve healthy volunteers with age range of 30-42 years provided baseline fecal...

journal_title：Journal of neurogastroenterology and motility

authors： Noh CK,Kim BS,Hong G,Cheong JY,Lee KJ

更新日期：2018-07-30 00:00:00

abstract：:Irritable bowel syndrome (IBS) has been one of the commonly presented gastrointestinal disorders. It is of interest how commonly it presents in the society. Western studies indicated that most population-based IBS prevalences range 10%-15%. It is believed that IBS is prevalent in both East and West countries without a...

journal_title：Journal of neurogastroenterology and motility

authors： Chang FY,Lu CL,Chen TS

更新日期：2010-10-01 00:00:00

abstract：BACKGROUND/AIMS:Approximately one-third of non-erosive reflux disease (NERD) patients are refractory to proton pump inhibitors (PPI) and face a therapeutic challenge. Therefore, it is important to differentiate between pathological and non-pathological reflux utilizing multichannel intraluminal impedance-pH (MII-pH) to...

journal_title：Journal of neurogastroenterology and motility

authors： Khan MQ,Alaraj A,Alsohaibani F,Al-Kahtani K,Jbarah S,Al-Ashgar H

更新日期：2014-10-30 00:00:00

abstract：BACKGROUND/AIMS:To draw a normative database of laryngopharynx pH profile in Chinese subjects. METHODS:Normal volunteers were recruited from "www.Ganji.com" and People's hospital between May 2008 and December 2009. The Restech pH Probes were calibrated in pH 7 and pH 4 buffer solutions according to the manufacturer's ...

journal_title：Journal of neurogastroenterology and motility

authors： Feng G,Wang J,Zhang L,Liu Y

更新日期：2014-07-31 00:00:00

abstract：:Constipation in children is a common health problem affecting 0.7% to 29.6% children across the world. Exact etiology for developing symptoms is not clear in children and the majority is considered to have functional constipation. Alteration of rectal and pelvic floor function through the brain-gut axis seems to play ...

journal_title：Journal of neurogastroenterology and motility

authors： Rajindrajith S,Devanarayana NM

更新日期：2011-01-01 00:00:00

abstract：Background/Aims:Recent studies suggest that air pollution may play a role in gastrointestinal disorders. However, the effect of long-term exposure to air pollution on childhood irritable bowel syndrome (IBS) is unclear. Hence, we conducted a nationwide cohort study to investigate the association between long-term air p...

journal_title：Journal of neurogastroenterology and motility

authors： Tan TK,Saps M,Lin CL,Wei CC

更新日期：2019-04-30 00:00:00

abstract：Background/Aims:Currently, there exists no biomarker for visceral hypersensitivity in irritable bowel syndrome (IBS). Piezo proteins have been proven to play an important role in the mechanical stimulation to induce visceral pain in other tissues and may also be a biomarker candidate. The aim of this study was to test ...

journal_title：Journal of neurogastroenterology and motility

authors： Bai T,Li Y,Xia J,Jiang Y,Zhang L,Wang H,Qian W,Song J,Hou X

更新日期：2017-07-30 00:00:00

abstract：BACKGROUND/AIMS:Antispasmodics including otilonium bromide (OB) are recommended to treat irritable bowel syndrome (IBS). However, reports about OB experience in Asia is sparse. The purpose of present study was to provide the efficacy of OB in treating Asian IBS patients. METHODS:Overall, 117 IBS patients meeting Rome ...

journal_title：Journal of neurogastroenterology and motility

authors： Chang FY,Lu CL,Luo JC,Chen TS,Chen MJ,Chang HJ

更新日期：2011-10-01 00:00:00

abstract：Background/Aims:The prevalence of eosinophilic esophagitis (EoE) is reportedly increasing in Western countries. However, its prevalence in Korea remains unknown. We investigated the diagnostic trends and clinical characteristics of EoE in Korea. Methods:Using an endoscopic database maintained at a tertiary care center...

journal_title：Journal of neurogastroenterology and motility

authors： Kim GH,Jung KW,Jung HY,Choi KD,Lee J,Park YS,Kim SW,Lee JH,Kim DH,Ahn JY,Song HJ,Lee GH,Kim JH

更新日期：2018-04-30 00:00:00

abstract：:An increase in intracellular Ca(2+) is the primary trigger of contraction of gastrointestinal (GI) smooth muscles. However, increasing the Ca(2+) sensitivity of the myofilaments by elevating myosin light chain phosphorylation also plays an essential role. Inhibiting myosin light chain phosphatase activity with protein...

journal_title：Journal of neurogastroenterology and motility

authors： Perrino BA

更新日期：2016-04-30 00:00:00