Genetics of sudden cardiac death in children and young athletes.

Abstract:

:Sudden cardiac death is a rare but socially devastating event. The most common causes of sudden cardiac death are congenital electrical disorders and structural heart diseases. The majority of these diseases have an incomplete penetrance and variable expression; therefore, patients may be unaware of their illness. In several cases, physical activity can be the trigger for sudden cardiac death as first symptom. Our purpose is to review the causes of sudden cardiac death in sportive children and young adults and its genetic background. Symptomatic individuals often receive an implantable cardioverter-defibrillator, the preventive treatment for sudden cardiac death in most of cases due to channelopathies, which can become a challenging option in young and active patients. The identification of one of these diseases in asymptomatic patients has similarly a great impact on their everyday life, especially on their ability to undertake competitive physical activities, and the requirement of prophylactic treatment. We review main causes of sudden cardiac death in relation to its genetics and diagnostic work-up

journal_name

Cardiol Young

journal_title

Cardiology in the young

authors

Sarquella-Brugada G,Campuzano O,Iglesias A,Sánchez-Malagón J,Guerra-Balic M,Brugada J,Brugada R

doi

10.1017/S1047951112001138

subject

Has Abstract

pub_date

2013-04-01 00:00:00

pages

159-73

issue

2

eissn

1047-9511

issn

1467-1107

pii

S1047951112001138

journal_volume

23

pub_type

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