Abstract:
:Microorganisms have evolved elaborate strategies to adhere to host cells and to evade the host complement and immune attack, ensuring survival in various host niches and dissemination into sterile parts of the human body. Streptococcus pneumoniae (the pneumococcus) is not only a commensal of the human respiratory tract but also the etiological agent of severe and life-threatening diseases. Pneumococcal attachment to mucosal surfaces is a highly dynamic process requiring the contact of pneumococcal surface-exposed proteins with soluble or immobilized host factors. These avid interactions may trigger proteolytic cascades or result in engagement of cell surface receptors and intracellularly associated signaling machineries for subsequent uptake of pneumococci into host cells. In the present review, the intimate communication of S. pneumoniae molecules recognizing adhesive matrix molecules (microbial surface components recognizing adhesive matrix molecules) with their host counterparts and their individual role in pneumococcal colonization is discussed.
journal_name
Mol Oral Microbioljournal_title
Molecular oral microbiologyauthors
Voss S,Gámez G,Hammerschmidt Sdoi
10.1111/j.2041-1014.2012.00654.xsubject
Has Abstractpub_date
2012-08-01 00:00:00pages
246-56issue
4eissn
2041-1006issn
2041-1014journal_volume
27pub_type
杂志文章,评审abstract::We have previously shown that benzamidine-type compounds can inhibit the activity of arginine-specific cysteine proteinases (gingipains HRgpA and RgpB); well-known virulence factors of Porphyromonas gingivalis. They also hinder in vitro growth of this important periodontopathogenic bacterium. Apparently growth arrest ...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12015
更新日期:2013-06-01 00:00:00
abstract::Biofilm formation and cell-cell sensing by the pioneer dental plaque colonizer Streptococcus gordonii are dependent upon arginine. This study aimed to identify genetic factors linking arginine-dependent responses and biofilm formation in S. gordonii. Isogenic mutants disrupted in genes required for the biosynthesis or...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12207
更新日期:2018-04-01 00:00:00
abstract::Porphyromonas gingivalis is a bacterial species that causes destruction of periodontal tissues. Additionally, previous evidence indicates that GroEL from P. gingivalis may possess biological activities involved in systemic inflammation, especially inflammation involved in the progression of periodontal diseases. The l...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12083
更新日期:2015-06-01 00:00:00
abstract::Toll-like receptor 9 (TLR9) expression is increased in periodontally diseased tissues compared with healthy sites indicating a possible role of TLR9 and its ligand, bacterial DNA (bDNA), in periodontal disease pathology. Here, we determine the immunostimulatory effects of periodontal bDNA in human monocytic cells (THP...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/j.2041-1014.2009.00551.x
更新日期:2010-04-01 00:00:00
abstract::Tannerella forsythia is implicated as a pathogen causing chronic and aggressive periodontitis. However, its virulence factors, including numerous putative proteases, are mostly uncharacterized. Karilysin is a newly described matrix metalloprotease-like enzyme of T. forsythia. Since pathogen-derived proteases may affec...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12080
更新日期:2014-12-01 00:00:00
abstract::Interbacterial adhesion between streptococci and actinomyces promotes early dental plaque biofilm development. Recognition of coaggregation receptor polysaccharides (RPS) on strains of Streptococcus sanguinis, Streptococcus gordonii and Streptococcus oralis by Actinomyces spp. type 2 fimbriae is the principal mechanis...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12042
更新日期:2014-02-01 00:00:00
abstract::Lactobacillus rhamnosus is a lactic acid bacterium with a diverse ecological habitat. We recently isolated a L. rhamnosus strain (LRB) from a healthy baby-tooth that had naturally fallen out. We determined the whole genome sequence of LRB and found that the isolate is closely genetically related to an intestinal isola...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12242
更新日期:2018-10-01 00:00:00
abstract::Streptococcus mutans is a cariogenic pathogen in humans. To persist in the oral cavity, S. mutans is resistant against several antibacterial factors derived from the host. In this study, we investigated the mechanism of resistance to cationic antimicrobial peptides (AMPs), which are innate immune factors in humans. Be...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/j.2041-1014.2012.00637.x
更新日期:2012-04-01 00:00:00
abstract::A hallmark of infection with the gram-negative pathogen Porphyromonas gingivalis is the induction of a chronic inflammatory response. P. gingivalis induces a local chronic inflammatory response that results in oral inflammatory bone destruction, which manifests as periodontal disease. In addition to chronic inflammati...
journal_title:Molecular oral microbiology
pub_type: 杂志文章,评审
doi:10.1111/j.2041-1014.2010.00582.x
更新日期:2010-10-01 00:00:00
abstract::The commensal oral microbial flora has evolved with the human host to support colonization of the various intraoral sites without triggering a significant immune response. In exchange, the commensal microbes provide critical protection against invading pathogens. The intrinsic ability of the oral flora to create a sym...
journal_title:Molecular oral microbiology
pub_type: 杂志文章,评审
doi:10.1111/omi.12170
更新日期:2017-06-01 00:00:00
abstract::A novel bacterium was isolated from the subgingival plaque of a patient with periodontal disease. Bacterial strain BA112T is a facultative Gram-positive coccus. It metabolizes alanine, arginine, glycine, histidine, leucine, proline, serine and tyrosine, but does not appear to use carbohydrates. Urease, esculin, indole...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12205
更新日期:2018-02-01 00:00:00
abstract::Although iron under anaerobic conditions is more accessible and highly reactive because of its reduced form, iron-dependent regulation is not well known in anaerobic bacteria. Here, we investigated iron- and hemin-dependent gene regulation in Porphyromonas gingivalis, an established periodontopathogen that primarily i...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12066
更新日期:2015-02-01 00:00:00
abstract::During periodontitis, alveolar bone resorption is associated with activation of T helper type 17 (Th17) lymphocytes and receptor activator of nuclear factor-κB ligand (RANKL) -induced osteoclasts. We previously reported that serotype b of Aggregatibacter actinomycetemcomitans has a higher capacity to trigger Th17-type...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12112
更新日期:2016-04-01 00:00:00
abstract::Lactobacillus rhamnosus is a lactic acid bacterium that survives diverse ecological niches, including the human oral cavity and gastrointestinal tract. L. rhamnosus is an acidogenic bacterium that produces copious amounts of lactic acid. The organism is also considered as aciduric, since it can survive prolonged expos...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12262
更新日期:2019-08-01 00:00:00
abstract::The NLRP3 inflammasome, an intracellular sensor consisting of the nucleotide-binding oligomerization domain-like receptor family, pyrin domain containing 3 (NLRP3), the adaptor protein apoptosis-associated speck-like protein containing a caspase-recruitment domain (ASC), and procaspase-1, plays critical roles in host ...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12225
更新日期:2018-08-01 00:00:00
abstract::To successfully colonize host cells, pathogenic bacteria must circumvent the host's structural barrier such as the collagen-rich extracellular matrix (ECM), as a preliminary step to invasion and colonization of the periodontal tissue. Filifactor alocis possesses a putative Peptidase U32 family protein (HMPREF0389_0050...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12163
更新日期:2017-04-01 00:00:00
abstract::Periodontal diseases are multifactorial infections elicited by a complex of primarily gram-negative bacteria that interact with host tissues and lead to the destruction of the periodontal structures. Bdellovibrio bacteriovorus is a gram-negative bacterium that preys upon other gram-negative bacteria. It was previously...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/j.2041-1014.2010.00592.x
更新日期:2011-02-01 00:00:00
abstract::The past decades of biomedical research have yielded massive evidence for the contribution of the microbiome in the development of a variety of chronic human diseases. There is emerging evidence that Porphyromonas gingivalis, a well-adapted opportunistic pathogen of the oral mucosa and prominent constituent of oral bi...
journal_title:Molecular oral microbiology
pub_type: 杂志文章,评审
doi:10.1111/omi.12047
更新日期:2014-04-01 00:00:00
abstract::Porphyromonas gingivalis (P. gingivalis) expres-ses the enzyme peptidylarginine deiminase (PPAD), which has a strong preference for C-terminal arginines. Due to the combined activity of PPAD and Arg-specific gingipains, P. gingivalis on the cell surface is highly citrullinated. To investigate the contribution of PPAD ...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12081
更新日期:2014-12-01 00:00:00
abstract::Microbial pathogens have evolved mechanisms to proactively manipulate innate immunity, thereby improving their fitness in mammalian hosts. We have previously shown that Porphyromonas gingivalis exploits CXC-chemokine receptor-4 (CXCR4) to instigate a subversive crosstalk with Toll-like receptor 2 that inhibits leukocy...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/j.2041-1014.2012.00657.x
更新日期:2012-12-01 00:00:00
abstract::The microbial plaque biofilm resides adjacent to the tissue-destructive inflammatory infiltrate in periodontitis. Although not sufficient, this biofilm is necessary for this inflammatory response. Patients with periodontitis generate antibodies specific for bacteria in the biofilm - although the role of these antibodi...
journal_title:Molecular oral microbiology
pub_type: 杂志文章,评审
doi:10.1111/omi.12144
更新日期:2016-12-01 00:00:00
abstract::Streptococcus mitis is a viridans streptococcus and a normal commensal of the human oropharynx. However, S. mitis can escape from this niche and cause a variety of infectious complications including infective endocarditis, bacteraemia and septicaemia. It uses a variety of strategies to effectively colonize the human o...
journal_title:Molecular oral microbiology
pub_type: 杂志文章,评审
doi:10.1111/j.2041-1014.2010.00601.x
更新日期:2011-04-01 00:00:00
abstract::Chronic periodontitis is one of the most common infectious inflammatory diseases worldwide. Current therapeutic options for the disease are only partially and temporarily successful due to periodontal re-emergence of pathogens such as Porphyromonas gingivalis, a keystone bacterium in the oral microbial communities, wh...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12305
更新日期:2020-10-01 00:00:00
abstract::In Porphyromonas gingivalis, the protein PG1660, composed of 174 amino acids, is annotated as an extracytoplasmic function (ECF) sigma factor (RpoE homologue-σ24). Because PG1660 can modulate several virulence factors and responds to environmental signals in P. gingivalis, its genetic properties were evaluated. PG1660...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12204
更新日期:2018-02-01 00:00:00
abstract::The use of next generation sequencing and bioinformatics has revealed the complexity and richness of the human oral microbiota. While some species are well known for their periodontal pathogenicity, the molecular-based approaches for bacterial identification have raised awareness about new putative periodontal pathoge...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12274
更新日期:2020-01-01 00:00:00
abstract::Desulfovibrio are sulfate-reducing anaerobic gram-negative rods that have been proposed as potential periodontopathogens. We investigated the capacity of Desulfovibrio to invade epithelial cells and induce cytokine secretion from these cells. Desulfovibrio strains were co-cultured with KB cells and counts of intracell...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/j.2041-1014.2009.00550.x
更新日期:2010-06-01 00:00:00
abstract::Treponema denticola, a periopathogen, evades complement-mediated killing by binding the negative complement regulatory protein factor H (FH) to its surface via the FhbB protein. Paradoxically, bound FH is cleaved by T. denticola's dentilisin protease, a process hypothesized to trigger localized dysregulation of comple...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12054
更新日期:2014-10-01 00:00:00
abstract::Mature dental biofilms consist of towering microcolonies in which the resident bacterial cells interact with one another and exchange messages in the form of signalling molecules and metabolites. These structures have been compared with the bustling office blocks and apartment buildings of busy cities. Social and comm...
journal_title:Molecular oral microbiology
pub_type: 杂志文章,评审
doi:10.1111/j.2041-1014.2009.00563.x
更新日期:2010-02-01 00:00:00
abstract::The present in vitro study examines molecular processes that are relevant during bone homeostasis after Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis infection with a focus on the differentiation level of osteoblasts. Regenerative processes are often hindered by the recurrence of bacterial infecti...
journal_title:Molecular oral microbiology
pub_type: 杂志文章
doi:10.1111/omi.12203
更新日期:2018-04-01 00:00:00
abstract::Chronic wounds, including pressure ulcers, foot ulcers, and venous leg ulcers, have a detrimental impact on the health and well-being of an estimated 2% of people in the UK. Chronic wounds are normally colonized by bacteria and in some instances bacterial load increases sufficiently for infection to ensue. Once a chro...
journal_title:Molecular oral microbiology
pub_type: 杂志文章,评审
doi:10.1111/omi.12174
更新日期:2017-08-01 00:00:00