Vinylphenylmercapturic acids in human urine as biomarkers of styrene ring oxidation.

Abstract:

:New metabolites of styrene, three isomeric vinylphenylmercapturic acids (2-, 3-, and 4-VPMA), were recently identified by LC-ESI-MS in the urine of mice. In this study, 4-VPMA together with traces of 2- and 3-VPMA were found also in the urine of hand-lamination workers, which were exposed to styrene vapours at concentrations ranging from 23 to 244mg/m(3). Concentrations of 4-VPMA in these end-of-shift samples were 4.59±3.64ng/mL (mean±S.D.; n=10), those found next morning after the work-shift were 2.14±2.07ng/mL (mean±S.D.; n=10). Strong correlation (R=0.959) was found in the next-morning samples between concentrations of 4-VPMA and phenylglyoxylic acid, whereas correlations found between 4-VPMA and mandelic acid in both end-of-shift and next-morning samples were much weaker. The excretion of 4-VPMA accounted for only about 3.5×10(-4)% of the absorbed dose of styrene. Despite very low metabolic yield, formation of VPMAs clearly indicates occurrence and extent of styrene ring oxidation considered to be a toxicologically relevant metabolic pathway.

journal_name

Toxicol Lett

journal_title

Toxicology letters

authors

Linhart I,Mráz J,Dabrowská L,Mališ M,Krouželka J,Kořínek M

doi

10.1016/j.toxlet.2012.06.012

subject

Has Abstract

pub_date

2012-09-03 00:00:00

pages

260-5

issue

2

eissn

0378-4274

issn

1879-3169

pii

S0378-4274(12)01176-9

journal_volume

213

pub_type

杂志文章
  • Activation of the cold-receptor TRPM8 by low levels of menthol in tobacco products.

    abstract::Activation of the cold-receptor TRPM8 by menthol or other tobacco additives can suppress natural defense reactions such as coughing that usually would become effective as involuntary resistance against the inhalation of fumes. In Europe menthol is only regulated as flavor, but can be used as additive as long as no cha...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2017.02.020

    authors: Paschke M,Tkachenko A,Ackermann K,Hutzler C,Henkler F,Luch A

    更新日期:2017-04-05 00:00:00

  • Effects of di-2-ethylhexyl phthalate on lipid composition of serum and testis in rats.

    abstract::Dietary administration of di-2-ethylhexyl phthalate (DEHP; 2%) to male rats caused testicular atrophy. Serum non-esterified fatty acid increased while cholesterol, triglyceride and phospholipid decreased in treated rats. Testicular concentration of cholesterol and non-esterified fatty acid increased in DEHP-treated ra...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(84)90011-0

    authors: Oishi S

    更新日期:1984-10-01 00:00:00

  • Relationship between the neurotoxicities of Soman, Sarin and Tabun, and acetylcholinesterase inhibition.

    abstract::Acetylcholinesterase (AChE)-induced chewing movements, tremors, convulsions and hind limb abduction at doses of 50-85% LD50 in rats were monitored in order to determine whether the severity of these different signs would correlate with brain AChE levels and the time course of such a relationship. 30 min after subcutan...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(86)90094-9

    authors: Hoskins B,Fernando JC,Dulaney MD,Lim DK,Liu DD,Watanabe HK,Ho IK

    更新日期:1986-02-01 00:00:00

  • Pneumotoxicity of butylated hydroxytoluene applied dermally to CD-1 mice.

    abstract::Pneumotoxicity of butylated hydroxytoluene (BHT) applied to the skin of CD-1 mice was investigated and compared with that of butylated hydroxyanisole (BHA). To 6 groups of 10 male mice and 10 female mice 0.1 ml of dimethylsulfoxide (DMSO) solutions containing 0, 5, 10, 20, or 30 mg of BHT or 30 mg of BHA were topicall...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(86)90151-7

    authors: Miyakawa Y,Takahashi M,Furukawa F,Toyoda K,Sato H,Hayashi Y

    更新日期:1986-11-01 00:00:00

  • Mutagenic effects of fluphenazine hydrochloride in Drosophila melanogaster.

    abstract::The mutagenic potential of fluphenazine hydrochloride was tested on male germ cells of Drosophila melanogaster. The criterion used was sex-linked recessive lethal mutations. Oregon-K males of D. melanogaster, reared on a medium containing 0.01, 0.02 and 0.03 mg/ml of the drug, were screened for sex-linked recessive le...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(80)90050-8

    authors: Rao KP,Rao MS

    更新日期:1980-12-01 00:00:00

  • Induction of chromosome aberrations by phenobarbitone in the germ cells of Swiss male mice.

    abstract::The cytogenetic effects of phenobarbitone were studied in the male germ cells of Swiss mice. The drug was orally administered at 42, 84 and 126 mg/kg body weight dose levels by sub-acute and chronic modes of treatment. In the treated series, the incidence of chromosome aberrations was significant at all dose levels. H...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(82)90002-9

    authors: Nandan SD,Rao MS

    更新日期:1982-11-01 00:00:00

  • Involvement of cytokines in the hepatic expression of metallothionein by ursolic acid.

    abstract::Ursolic acid (UA), a pentacyclic triterpene acid, is reported to have inducing activity of hepatic metallothionein (MT) which responsible for the detoxification of heavy metals; however, the mechanism underlying its effects is poorly understood. To further determine the underlying mechanism of UA, this study investiga...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2004.11.002

    authors: Jeong HG,Kim HG,Hwang YP

    更新日期:2005-03-15 00:00:00

  • Cytogenetic investigations in employees from waste disposal sites.

    abstract::In connection with extensive health studies of employees from two big central waste disposal sites, cytogenetic investigations were performed. The subject of these special analyses was to examine whether the complex mixture of pollutants from waste disposal sites comprises a genotoxic hazardous potential. Cytogenetic ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00062-9

    authors: Fender H,Wolf G

    更新日期:1998-08-01 00:00:00

  • Evaluation of combined toxic effects of GB/GF and efficacy of jielin injection against combined poisoning in mice.

    abstract::A computer program (Q-test) was used to evaluate the combined toxic effects of nerve agent GF and its combined form with sarin (GB/GF) in mice. Efficacy of Jielin Injection, the 2-PAM-containing antidote used successfully in China for the treatment of organophosphate pesticide poisoning, was also evaluated and compare...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(97)00057-x

    authors: Luo C,Liang J

    更新日期:1997-08-22 00:00:00

  • Effect of vitamin C on plasma total antioxidant status in patients with paraquat intoxication.

    abstract::This study was conducted to evaluate whether vitamin C (VC) was associated with total antioxidant status (TAS) in human plasma and to determine the usefulness of VC on TAS in the treatment of patients with paraquat poisoning. VC and TAS were measured in 56 healthy subjects. Then, various concentrations (1-100 mg/dl) o...

    journal_title:Toxicology letters

    pub_type: 临床试验,杂志文章

    doi:10.1016/s0378-4274(01)00431-3

    authors: Hong SY,Hwang KY,Lee EY,Eun SW,Cho SR,Han CS,Park YH,Chang SK

    更新日期:2002-01-05 00:00:00

  • Bardoxolone methyl modulates efflux transporter and detoxifying enzyme expression in cisplatin-induced kidney cell injury.

    abstract::Cisplatin is prescribed for the treatment of solid tumors and elicits toxicity to kidney tubules, which limits its clinical use. Nuclear factor erythroid 2-related factor 2 (Nrf2, NFE2L2) is a critical transcription factor that has been shown to protect against kidney injury through activation of antioxidant mechanism...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2016.07.021

    authors: Atilano-Roque A,Aleksunes LM,Joy MS

    更新日期:2016-09-30 00:00:00

  • Ten-day repeated-exposure inhalation study of dimethylformamide (DMF) in cynomolgus monkeys.

    abstract::Cynomolgus monkeys showed no measurable adverse effects following inhalation of 500 ppm dimethylformamide (DMF), 6 h/d, 5 d/wk, for 2 weeks either when exposed whole-body or head-only (one monkey per exposure route). Measurement of DMF concentrations into and out of the head-only exposure unit along with measurement o...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(91)90076-i

    authors: Hurtt ME,McCooey KT,Placke ME,Kennedy GL

    更新日期:1991-12-01 00:00:00

  • Acid hydrolases in brain, spinal cord and sciatic nerves of acrylamide-intoxicated rats.

    abstract::Activity of beta-glucuronidase and cathepsin-D were studied in brain, spinal cord and sciatic nerves of rats at 24 h or 10 days after daily i.p. administration of 50 mg/kg acrylamide. The activities of beta-glucuronidase and cathepsin-D in brain, spinal cord and sciatic nerves remained unaffected on single exposure bu...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(84)90068-7

    authors: Srivastava SP,Srivastava SP,Seth PK

    更新日期:1984-08-01 00:00:00

  • One-month persistence of inflammation and alteration of fibrotic marker and cytoskeletal proteins in rat kidney after Cd-doped silica nanoparticle instillation.

    abstract::In vivo effects of model cadmium-containing silica nanoparticles (SiNPs-Cd, 1 mg/rat) were investigated by i.t. instillation in rats to evaluate potential effects on secondary target organ, e.g., kidney. Specific endpoints and pathological outcomes were focused to assess inflammation and fibrosis in renal tissue, 7 an...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2014.11.021

    authors: Coccini T,Barni S,Mustarelli P,Locatelli C,Roda E

    更新日期:2015-01-22 00:00:00

  • Rat hepatic CYP1A1 and CYP1A2 induction by menadione.

    abstract::The effects of menadione on activities and expression of cytochrome P450 (CYP) 1A subfamily (CYP1A) isozymes in rat hepatic tissue were examined. When rats were treated orally with 15 mg/kg menadione for 4 days, the elevation of hepatic CYP1A1/1A2 specific activities in microsomal preparations was detected with approx...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2004.10.001

    authors: Sidorova YA,Grishanova AY,Lyakhovich VV

    更新日期:2005-02-15 00:00:00

  • The effects of n-alcohols on evoked synaptic potentials in rat hippocampal slices: Hill coefficients account for the cut-off phenomenon.

    abstract::The anesthetic potencies of n-alcohols increase progressively with lengthening of the carbon chain and then disappear at a cut-off point of a longer-chain n-alcohol. In order to assess the mechanisms for cut-off in mammalian central nervous system, the effects of a series of n-alcohols (C(2)-C(11)) were examined on th...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(00)00186-7

    authors: Takehana K,Hirota K,Roth SH,Masuda A,Ito Y

    更新日期:2000-05-19 00:00:00

  • Central respiratory effects on motor nerve activities after organophosphate exposure in a working heart brainstem preparation of the rat.

    abstract::The impact of organophosphorus compound (OP) intoxication on the activity of central respiratory circuitry, causing acetylcholinesterase (AChE) inhibition and accumulation of acetylcholine in the respiratory brainstem circuits, is not understood. We investigated the central effect of the OP Crotylsarin (CRS) on respir...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2011.07.005

    authors: Klein-Rodewald T,Seeger T,Dutschmann M,Worek F,Mörschel M

    更新日期:2011-09-25 00:00:00

  • Effects of primary metabolites of organophosphate flame retardants on transcriptional activity via human nuclear receptors.

    abstract::Organophosphate flame retardants (OPFRs) have been used in a wide variety of applications and detected in several environmental matrices, including indoor air and dust. Continuous human exposure to these chemicals is of growing concern. In this study, the agonistic and/or antagonistic activities of 12 primary OPFR-met...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2016.01.004

    authors: Kojima H,Takeuchi S,Van den Eede N,Covaci A

    更新日期:2016-03-14 00:00:00

  • Metal environmental contamination within different human exposure context- specific and non-specific biomarkers.

    abstract::Exposure to high levels of persistent pollutants, such as metal mixtures, is commonly encountered by the general population especially in industrialized countries. The aim of this work was to evaluate how metal pollution in contaminated areas is reflected in terms of biomarkers (BMs) of exposure and effect in human su...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.12.022

    authors: de Andrade VL,Cota M,Serrazina D,Mateus ML,Aschner M,Dos Santos APM

    更新日期:2020-05-15 00:00:00

  • Heavy metal-induced cytotoxicity to cultured human epidermal keratinocytes and effects of antioxidants.

    abstract::Human epidermal keratinocytes which have been cultured were treated with the heavy metal ions of cadmium, mercury, copper and zinc. Cytotoxicity was measured either by protein estimation or by using the neutral red assay. Antioxidants were added in order to find out whether heavy metal-induced cytotoxicity is related ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90170-8

    authors: Kappus H,Reinhold C

    更新日期:1994-04-01 00:00:00

  • Subchronic oral toxicity of turmeric and ethanolic turmeric extract in female mice and rats.

    abstract::Subchronic oral toxicity of turmeric and ethanolic turmeric extract was studied in female Swiss mice and Wistar rats fed turmeric (0, 1 and 5%) and ethanolic turmeric extract (0, 0.05 and 0.25%) through diet for 14 and/or 90 days. The administration of a high dose of turmeric (5%) for longer duration (90 days) showed ...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00035-6

    authors: Deshpande SS,Lalitha VS,Ingle AD,Raste AS,Gadre SG,Maru GB

    更新日期:1998-05-01 00:00:00

  • The mechanism of methyl mercury toxicity in isolated rat hepatocytes.

    abstract::Mercury is the major component of dental amalgam restorative material, which typically has 50% pure elemental mercury. It is also used in some skin creams, and in the manufacturing of plastic, drugs and fungicides. The present study was designed to investigate the toxicity of methyl mercury (MeHg+) on isolated rat hep...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(93)90149-r

    authors: Ashour H,Abdel-Rahman M,Khodair A

    更新日期:1993-07-01 00:00:00

  • A new photosafety screening strategy based on in chemico photoreactivity and in vitro skin exposure for dermally-applied chemicals.

    abstract::This study involved an attempt to establish a new photosafety screening system for dermally-applied chemicals consisting of a reactive oxygen species (ROS) assay and an in vitro skin permeation test. The ROS assay was undertaken to evaluate photoreactivity of six test compounds, acridine (ACD), furosemide (FSM), hexac...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.09.016

    authors: Iyama Y,Sato H,Seto Y,Onoue S

    更新日期:2019-12-15 00:00:00

  • No increase in carcinogen-DNA adducts in the lungs of monkeys exposed chronically to marijuana smoke.

    abstract::Rhesus monkeys exposed to marijuana smoke either 7 or 2 days/weeks (HI and LO groups, respectively), or ethanol-extracted marijuana smoke for 7 days/week (EM) or sham treatment (SH) for 1 year were sacrificed 7 months following the last exposure. Pulmonary levels of carcinogen-DNA adducts were determined. Although mea...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(92)90094-z

    authors: Talaska G,Schamer M,Bailey JR,Ali SF,Scallet AC,Slikker W Jr,Paule MG

    更新日期:1992-12-01 00:00:00

  • AZT-induction of micronuclei in human lymphocyte subpopulations.

    abstract::Micronucleus (MN) induction by azidothymidine (AZT) in B and T lymphocytes was analyzed by a recently developed MAC (morphology-antibody-chromosome) method which allows the immunologic identification of different cell lineages. An increased frequency of MN in AZT-treated cultures compared with controls was observed. C...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(94)90167-8

    authors: Stern M,Cid MG,Larripa I,Slavutsky I

    更新日期:1994-02-01 00:00:00

  • Environmental exposure to pesticides and risk of thyroid diseases.

    abstract::Occupational and environmental exposure to pesticides has been associated with thyroid dysfunction, particularly changes in circulating thyroid hormone levels (T3, T4) and thyroid stimulating hormone (TSH). This study assessed the association between environmental exposure to pesticides and the risk of developing thyr...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2019.08.017

    authors: Requena M,López-Villén A,Hernández AF,Parrón T,Navarro Á,Alarcón R

    更新日期:2019-10-15 00:00:00

  • TRPA1 and CGRP antagonists counteract vesicant-induced skin injury and inflammation.

    abstract::The skin is highly sensitive to the chemical warfare agent in mustard gas, sulfur mustard (SM) that initiates a delayed injury response characterized by erythema, inflammation and severe vesication (blistering). Although SM poses a continuing threat, used as recently as in the Syrian conflict, no mechanism-based antid...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/j.toxlet.2018.03.007

    authors: Achanta S,Chintagari NR,Brackmann M,Balakrishna S,Jordt SE

    更新日期:2018-09-01 00:00:00

  • Measuring problems in estimating the exposure to passive smoking using the excretion of cotinine.

    abstract::Quality control studies on cotinine measurements following low level environmental tobacco smoke (ETS) exposure are rare. The exposure to ETS was controlled and systematically changed in a series of experiments in a climatic chamber. Healthy nonsmoking volunteers were exposed to ETS simultaneously. The duration and le...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(87)90083-x

    authors: Letzel H,Fischer-Brandies A,Johnson LC,Uberla K,Biber A

    更新日期:1987-01-01 00:00:00

  • Molecular failure of apoptosis: inappropriate cell survival and mutagenesis?

    abstract::Since cell death by apoptosis is achieved through complex interactions between numerous molecular components, cells may fail to die when stimulated because of molecular abnormalities in the apoptosis pathway or in its control mechanisms. Such inappropriate cell survival is well established when apoptosis is suppressed...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/s0378-4274(98)00343-9

    authors: Williams GT,Critchlow MR,Hedge VL,O'Hare KB

    更新日期:1998-12-28 00:00:00

  • A physiologically based model of skeletal growth in the rat.

    abstract::A model of the growing small animal skeleton has been developed. The model accurately reproduces a variety of different kinds of measurements made at different ages in different species, as well as reproducing a precise and detailed series of measurements in the growing guinea pig. Of the multiple mechanisms responsib...

    journal_title:Toxicology letters

    pub_type: 杂志文章

    doi:10.1016/0378-4274(88)90022-7

    authors: O'Flaherty EJ

    更新日期:1988-10-01 00:00:00