Complete genome sequence of the strong mutator Salmonella enterica subsp. enterica serotype Heidelberg strain B182.

Abstract:

:In bacteria, normal mutation frequencies are mostly around 10(-10) per base pair. However, there exists natural isolates, called "mutators," that exhibit permanent mutation occurrences up to 1,000-fold greater than usual. As mutations play essential roles, particularly in the evolution of antibiotic resistance, bacteria showing elevated mutation rates could have an important responsibility in the emergence of antibiotic resistance, especially in the clinical background. In this announcement, we report the first complete genome sequence of the Salmonella enterica subsp. enterica serotype Heidelberg B182 mutator strain, isolated from bovine feces (France), which consists of a 4,750,465-bp circular chromosome (cB182_4750; GC, 52.2%) and one circular plasmid of 37,581 bp (pB182_37; GC, 42.8%).

journal_name

J Bacteriol

journal_title

Journal of bacteriology

authors

Le Bars H,Bousarghin L,Bonnaure-Mallet M,Jolivet-Gougeon A,Barloy-Hubler F

doi

10.1128/JB.00498-12

subject

Has Abstract

pub_date

2012-07-01 00:00:00

pages

3537-8

issue

13

eissn

0021-9193

issn

1098-5530

pii

194/13/3537

journal_volume

194

pub_type

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