Human retinal pigment epithelium contains two distinct species of superoxide dismutase.

abstract：:The authors have examined the fate of intravitreally injected liposomes in the aphakic, vitrectomized eye of the rabbit. Liposomes labelled with 125[I]-p-hydroxybenzimidylphosphatidylethanolamine were eliminated rapidly from the intraocular fluid. Nonetheless, a significant fraction of these liposomes were found to bi...

journal_title：Investigative ophthalmology & visual science

authors： Stern WH,Heath TD,Lewis GP,Guerin CJ,Erickson PA,Lopez NG,Hong KL

更新日期：1987-05-01 00:00:00

abstract：PURPOSE:We reviewed and illustrated the most optimal retinal structural measurements to make in stem cell clinical trials. METHODS:Optical coherence tomography (OCT) and autofluorescence (AF) imaging were used to evaluate patients with severe visual loss from nonsyndromic and syndromic retinitis pigmentosa (RP), ABCA4...

journal_title：Investigative ophthalmology & visual science

authors： Jacobson SG,Matsui R,Sumaroka A,Cideciyan AV

更新日期：2016-04-01 00:00:00

abstract：PURPOSE:Retinal dopamine deficiency is a potential cause of myopia and visual deficits in retinopathy of prematurity (ROP). We investigated the cellular mechanisms responsible for lowered levels of retinal dopamine in an oxygen-induced retinopathy (OIR) mouse model of ROP. METHODS:Retinopathy was induced by exposing m...

journal_title：Investigative ophthalmology & visual science

authors： Spix NJ,Liu LL,Zhang Z,Hohlbein JP,Prigge CL,Chintala S,Ribelayga CP,Zhang DQ

更新日期：2016-06-01 00:00:00

abstract：PURPOSE:To study transition zones from normal to abnormal retina in Usher syndrome IB (USH1B) caused by myosin 7A (MYO7A) mutations. METHODS:Optical coherence tomography (OCT) scattering layers in outer retina were segmented in patients (n = 16, ages 2-42; eight patients had serial data, average interval 4.5 years) to...

journal_title：Investigative ophthalmology & visual science

authors： Sumaroka A,Matsui R,Cideciyan AV,McGuigan DB 3rd,Sheplock R,Schwartz SB,Jacobson SG

更新日期：2016-07-01 00:00:00

abstract：:Light and electron microscopic studies were done on 11 cynomolgus monkey eyes which had undergone total iris removal followed by surgical disinsertion of the ciliary muscle from the scleral spur 4.7 to 14.4 months earlier. Anterior chamber perfusion to measure gross outflow facility had been performed one to nine time...

journal_title：Investigative ophthalmology & visual science

authors： Lütjen-Drecoll E,Kaufman PL,Bárány EH

更新日期：1977-03-01 00:00:00

abstract：PURPOSE:To investigate the mechanism of σ receptor 1 (σR1) neuroprotection in retinal neurons. METHODS:Oxidative stress, which is implicated in diabetic retinopathy, was induced in mouse primary ganglion cells (GCs) and RGC-5 cells, and the effect of the σR1 ligand (+)-pentazocine on pro- and anti-apoptotic and endopl...

journal_title：Investigative ophthalmology & visual science

authors： Ha Y,Dun Y,Thangaraju M,Duplantier J,Dong Z,Liu K,Ganapathy V,Smith SB

更新日期：2011-01-25 00:00:00

abstract：PURPOSE:To investigate the intracellular mechanisms that induce amyloid beta (Abeta) accumulation and angiogenesis in the human retinal pigment epithelial cell line ARPE19. METHODS:The authors used two endoplasmic reticulum (ER) stress-inducing reagents, thapsigargin (TG), which inhibits the sarcoplasmic/endoplasmic c...

journal_title：Investigative ophthalmology & visual science

authors： Koyama Y,Matsuzaki S,Gomi F,Yamada K,Katayama T,Sato K,Kumada T,Fukuda A,Matsuda S,Tano Y,Tohyama M

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:To determine whether constitutive signal flow arising from defective rhodopsin shut-off causes photoreceptor cell death in arrestin knockout mice. METHODS:The retinas of cyclic-light-reared, pigmented arrestin knockout mice and wild-type littermate control mice were examined histologically for photoreceptor ce...

journal_title：Investigative ophthalmology & visual science

authors： Chen J,Simon MI,Matthes MT,Yasumura D,LaVail MM

更新日期：1999-11-01 00:00:00

abstract：PURPOSE:There is uncertainty in the published literature as to whether physical activity should be advocated for age-related macular degeneration (AMD) prevention. We aimed to assess prospectively the association between physical activity and the 15-year incidence of AMD in older adults. METHODS:We assessed AMD from r...

journal_title：Investigative ophthalmology & visual science

authors： Gopinath B,Liew G,Burlutsky G,Mitchell P

更新日期：2014-11-11 00:00:00

abstract：PURPOSE:To determine the mechanism that leads to the UVA light-dependent loss of glutathione reductase (GR) activity in human lens (HL). METHODS:Both the HL water-soluble (WS) fraction and yeast GR were irradiated with UVA light (200 mW/(cm(2). h) for 1 hour at +20 degrees C, and the specific activity (SA) was observe...

journal_title：Investigative ophthalmology & visual science

authors： Linetsky M,Hill JM,Chemoganskiy VG,Hu F,Ortwerth BJ

更新日期：2003-09-01 00:00:00

abstract：PURPOSE:To report neural rim dimensions for South Indians and examine rim shape with relevance to clinical evaluation. METHODS:Healthy phakic participants (n = 623) of the Chennai Glaucoma Study with normal frequency-doubling perimetry underwent complete eye examinations including optic disc digital stereophotography....

journal_title：Investigative ophthalmology & visual science

authors： Arvind H,George R,Raju P,Ve RS,Mani B,Kannan P,Vijaya L

更新日期：2008-08-01 00:00:00

abstract：PURPOSE:To investigate the role of leukotriene B4 (LTB4) and its receptor BLT1 in the pathogenesis of mouse uveitis. METHODS:Experimental autoimmune uveitis (EAU) was induced in B10RIII mice by immunization of interphotoreceptor retinoid binding protein (IRBP; peptide sequence 161-180) or in C57BL/6 (B6) mice by trans...

journal_title：Investigative ophthalmology & visual science

authors： Liao T,Ke Y,Shao WH,Haribabu B,Kaplan HJ,Sun D,Shao H

更新日期：2006-04-01 00:00:00

abstract：Purpose:To investigate the plasma concentration of nicotinamide in primary open-angle glaucoma (POAG). Methods:Plasma of 34 POAG individuals was compared to that of 30 age- and sex-matched controls using a semiquantitative method based on liquid chromatography coupled to high-resolution mass spectrometry. Subsequently...

journal_title：Investigative ophthalmology & visual science

authors： Kouassi Nzoughet J,Chao de la Barca JM,Guehlouz K,Leruez S,Coulbault L,Allouche S,Bocca C,Muller J,Amati-Bonneau P,Gohier P,Bonneau D,Simard G,Milea D,Lenaers G,Procaccio V,Reynier P

更新日期：2019-06-03 00:00:00

abstract：PURPOSE:To study retinal structure in choroideremia patients and carriers using high-resolution imaging techniques. METHODS:Subjects from four families (six female carriers and five affected males) with choroideremia (CHM) were characterized with best-corrected visual acuity (BCVA), kinetic and static perimetry, full-...

journal_title：Investigative ophthalmology & visual science

authors： Syed R,Sundquist SM,Ratnam K,Zayit-Soudry S,Zhang Y,Crawford JB,MacDonald IM,Godara P,Rha J,Carroll J,Roorda A,Stepien KE,Duncan JL

更新日期：2013-02-01 00:00:00

abstract：PURPOSE:To evaluate the efficacy of a computerized optokinetic nystagmus (OKN) test in detecting visual acuity (VA) of >20/200. METHODS:This was a combined retrospective and prospective, noninterventional study. In phase I of the study, data from 168 eyes of 154 subjects who underwent the computerized objective VA tes...

journal_title：Investigative ophthalmology & visual science

authors： Han SB,Yang HK,Hyon JY,Seo JM,Lee JH,Lee IB,Hwang JM

更新日期：2011-09-27 00:00:00

abstract：PURPOSE:To describe the phenotype caused by a retinol deficiency in a family with compound heterozygous missense mutations (Ile41Asn and Gly75Asp) in the gene for serum retinol binding protein (RBP). METHODS:The two affected sisters, 17 (BR) and 13 (MR) years old, were examined clinically and with perimetry, color vis...

journal_title：Investigative ophthalmology & visual science

authors： Seeliger MW,Biesalski HK,Wissinger B,Gollnick H,Gielen S,Frank J,Beck S,Zrenner E

更新日期：1999-01-01 00:00:00

abstract：PURPOSE:China has among the lowest cataract surgical rates in Asia. This study was conducted to identify barriers to cataract surgery in rural China. METHODS:All subjects having undergone cataract surgery and persons with presenting visual acuity or=1 eye due to nons...

journal_title：Investigative ophthalmology & visual science

authors： Yin Q,Hu A,Liang Y,Zhang J,He M,Lam DS,Ge J,Wang N,Friedman DS,Zhao J,Congdon N

更新日期：2009-03-01 00:00:00

abstract：PURPOSE:Fibrillins are the major constituent of tissue microfibrils, which form the ocular zonule. In Marfan syndrome (MFS), FBN1 mutations lead to ectopia lentis. The goal of this work was to investigate zonule composition and formation in fibrillin-deficient and wild-type mice. METHODS:Immunofluorescence staining of...

journal_title：Investigative ophthalmology & visual science

authors： Beene LC,Wang LW,Hubmacher D,Keene DR,Reinhardt DP,Annis DS,Mosher DF,Mecham RP,Traboulsi EI,Apte SS

更新日期：2013-12-23 00:00:00

abstract：PURPOSE:Recently, a segregation study in families with uveal and cutaneous melanoma identified 9q21 as a potential locus harboring a tumor-suppressor gene (TSG). One of the genes in this area, RASEF, was then analyzed as a candidate TSG, but lack of point mutations and copy number changes could not confirm this. In thi...

journal_title：Investigative ophthalmology & visual science

authors： Maat W,Beiboer SH,Jager MJ,Luyten GP,Gruis NA,van der Velden PA

更新日期：2008-04-01 00:00:00

abstract：PURPOSE:To investigate the role of the gap junction protein connexin43 (Cx43), which is predominantly expressed in lens epithelial cells in the control of lens development and organization. METHODS:Newborn mice in which the Cx43 gene was disrupted by homologous recombination were used. Lenses from Cx43 (-/-) mice and ...

journal_title：Investigative ophthalmology & visual science

authors： Gao Y,Spray DC

更新日期：1998-06-01 00:00:00

abstract：PURPOSE:The aim of this study was to determine the function of the tight junction protein occludin in the control of permeability, under diffusive and hydrostatic pressures, and its contribution to the control of cell division in retinal pigment epithelium. METHODS:Occludin expression was inhibited in the human retina...

journal_title：Investigative ophthalmology & visual science

authors： Phillips BE,Cancel L,Tarbell JM,Antonetti DA

更新日期：2008-06-01 00:00:00

abstract：PURPOSE:Heparanase and VEGF are related closely to angiogenesis in cancer. The purpose of our study was to evaluate the expression and correlation of heparanase and VEGF in hypoxia-induced retinal neovascularization. METHODS:C57BL/6 oxygen-induced retinopathy (OIR) mice and human retinal microvascular endothelial cell...

journal_title：Investigative ophthalmology & visual science

authors： Hu J,Song X,He YQ,Freeman C,Parish CR,Yuan L,Yu H,Tang S

更新日期：2012-10-03 00:00:00

abstract：PURPOSE:To evaluate the expression of tissue inhibitor of metalloproteinases (TIMP) mRNA in corneal tissues before and at early time points (6 and 12 hours and 1, 3, and 5 days) after corneal infection with Pseudomonas aeruginosa. METHODS:Ribonuclease protection assays were used to detect and quantitate TIMP mRNA expr...

journal_title：Investigative ophthalmology & visual science

authors： Kernacki KA,Goebel DJ,Poosch MS,Hazlett LD

更新日期：1998-02-01 00:00:00

abstract：:The life history of melanin and lipofuscin granules of human retinal pigment epithelium (RPE) was studied in 30 human eyes spanning nine decades of life. Autofluorescent granules in the cytoplasm of eye over 30 years of age were shown, ultrastructurally and through lipid solvent extraction, to be lipofuscin granules. ...

journal_title：Investigative ophthalmology & visual science

authors： Feeney L

更新日期：1978-07-01 00:00:00

abstract：PURPOSE:To characterize a new nontransfected, spontaneously immortalized epithelial cell line from normal human conjunctiva (IOBA-NHC), both morphologically and functionally, to determine whether the differentiated phenotype of conjunctival epithelial cells is preserved. METHODS:Outgrowing cells from explanted conjunc...

journal_title：Investigative ophthalmology & visual science

authors： Diebold Y,Calonge M,Enríquez de Salamanca A,Callejo S,Corrales RM,Sáez V,Siemasko KF,Stern ME

更新日期：2003-10-01 00:00:00

abstract：PURPOSE:Refraction, as measured by spherical equivalent, is the need for an external lens to focus images on the retina. While genetic factors play an important role in the development of refractive errors, few susceptibility genes have been identified. However, several regions of linkage have been reported for myopia ...

journal_title：Investigative ophthalmology & visual science

authors： Klein AP,Duggal P,Lee KE,Cheng CY,Klein R,Bailey-Wilson JE,Klein BE

更新日期：2011-07-13 00:00:00

abstract：:Nonenzymatic glycated lens alpha-crystallin, isolated from human diabetic cataract lenses, does not differ in subunit size and secondary structure from nonglycated alpha-crystallin. The tertiary structure, however, has undergone a significant change as reflected in the changes of near-ultraviolet (UV) circular dichroi...

journal_title：Investigative ophthalmology & visual science

authors： Liang JN,Chylack LT Jr

更新日期：1987-05-01 00:00:00

abstract：:We describe an instrument called a scanning ocular spectrofluorophotometer (SOSF) that measures fluorescence in a two-dimensional cross-section through the anterior chamber and cornea and provides the ability to change excitation and emission wavelengths rapidly. The output of a xenon arc lamp is filtered by a diffrac...

journal_title：Investigative ophthalmology & visual science

authors： McLaren JW,Brubaker RF

更新日期：1988-08-01 00:00:00

abstract：PURPOSE:Phakic intraocular lenses (pIOLs) are used for correcting vision; in this paper we investigate the fluid dynamical effects of an iris-fixated lens in the anterior chamber. In particular, we focus on changes in the wall shear stress (WSS) on the cornea and iris, which could be responsible for endothelial and pig...

journal_title：Investigative ophthalmology & visual science

authors： Repetto R,Pralits JO,Siggers JH,Soleri P

更新日期：2015-05-01 00:00:00

abstract：PURPOSE:To compare visual evoked potentials (VEPs) and contrast sensitivity in adults with early- or late-onset strabismic amblyopia. METHODS:Twelve adults with early- and 12 with late-onset strabismic amblyopia with similar ranges of visual acuity were studied. Pattern-onset VEPs to 30-minute checks were recorded at ...

journal_title：Investigative ophthalmology & visual science

authors： Davis AR,Sloper JJ,Neveu MM,Hogg CR,Morgan MJ,Holder GE

更新日期：2003-02-01 00:00:00