Abstract:
BACKGROUND:Bone metastasis developing after differentiated thyroid carcinoma (DTC) is common, and in most cases, this condition leads to osteolysis. However, treatment of bone metastases in DTC patients is a great challenge. The purpose of this study was to evaluate the effectiveness of percutaneous osteoplasty (POP) combined with radioiodine therapy for treating bone metastasis developing after DTC. PATIENTS AND METHODS:We retrospectively studied 8 patients who had undergone POP combined with radioiodine therapy for bone metastases after DTC. All patients underwent total thyroidectomy and were administered an oral dose of 131I (3.7 GBq, 100 mCi) for ablation of the residual thyroid. Thereafter, a POP was performed at 2 to 3 months followed by 2 to 5 sessions of radioiodine therapy every 4 to 6 months after the first 131I therapy. The therapeutic effectiveness of this treatment was evaluated on the basis of the changes in serum thyroglobulin (Tg) level and imaging characteristics, palliation of bone pain, and alleviation of neurologic symptoms. RESULTS:After POP, the mean serum Tg level decreased by 86.0% (range, 68.1%-99.3%). The mean serum Tg level markedly declined further by 67.4% (range, 37.1%-90.2%) after repeated radioiodine therapy. All the patients experienced immediate and substantial alleviation of bone pain and neurologic symptoms, and their quality of life markedly improved. The bone-destructive lesions were filled with bone cement to enhance skeletal stability. No severe complications developed. CONCLUSION:POP, a minimally invasive procedure, combined with radioiodine therapy seems to be highly effective in providing pain relief and bone stability and in improving the quality of life of DTC patients with bone metastases. After POP, radioiodine therapy is essential.
journal_name
Clin Nucl Medjournal_title
Clinical nuclear medicineauthors
Song HJ,Wu CG,Xue YL,Xu YH,Qiu ZL,Luo QYdoi
10.1097/RLU.0b013e31824786d0subject
Has Abstractpub_date
2012-06-01 00:00:00pages
e129-33issue
6eissn
0363-9762issn
1536-0229pii
00003072-201206000-00028journal_volume
37pub_type
杂志文章abstract::Ocular metastases secondary to thyroid cancer are extremely uncommon, typically affecting the orbit rather than the globe and uvea. Within the uveal structures, the choroid is more commonly involved than the iris and ciliary body. We present a 56-year-old male patient who underwent total thyroidectomy for metastatic p...
journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章,评审
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abstract::The Transcatheter Valve Therapy Registry has been very helpful in providing data to better understand patient risk factors for transcatheter aortic valve replacement (TAVR). The outcome of TAVR depends on many patient indicators, some of which are given in this article, including the age, dependence on oxygen, classif...
journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/RLU.0b013e318263907b
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更新日期:2012-01-01 00:00:00
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更新日期:1991-01-01 00:00:00
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journal_title:Clinical nuclear medicine
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doi:10.1097/00003072-198605000-00008
更新日期:1986-05-01 00:00:00
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journal_title:Clinical nuclear medicine
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doi:
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journal_title:Clinical nuclear medicine
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
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更新日期:2009-04-01 00:00:00
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更新日期:1993-10-01 00:00:00
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更新日期:2018-01-01 00:00:00
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journal_title:Clinical nuclear medicine
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doi:10.1097/00003072-197907000-00001
更新日期:1979-07-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 临床试验,杂志文章
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更新日期:2001-02-01 00:00:00
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更新日期:2017-02-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199708000-00006
更新日期:1997-08-01 00:00:00
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journal_title:Clinical nuclear medicine
pub_type: 杂志文章
doi:10.1097/00003072-199509000-00012
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