Abstract:
:Bovine lactoferrin (bLf) is a multifunctional glycoprotein that plays an important role in innate immunity against infections, including influenza. Here we have dissected bLf into its C- and N-lobes and show that inhibition of influenza virus hemagglutination and cell infection is entirely attributable to the C-lobe and that all major virus subtypes, including H1N1 and H3N2, are inhibited. By far-western blotting and sequencing studies, we demonstrate that bLf C-lobe strongly binds to the HA(2) region of viral hemagglutinin, precisely the highly conserved region containing the fusion peptide. By molecular docking studies, three C-lobe fragments were identified which inhibited virus hemagglutination and infection at fentomolar concentration range. Besides contributing to explain the broad anti-influenza activity of bLf, our findings lay the foundations for exploiting bLf fragments as source of potential anti-influenza therapeutics.
journal_name
Pathog Glob Healthjournal_title
Pathogens and global healthauthors
Ammendolia MG,Agamennone M,Pietrantoni A,Lannutti F,Siciliano RA,De Giulio B,Amici C,Superti Fdoi
10.1179/2047773212Y.0000000004subject
Has Abstractpub_date
2012-03-01 00:00:00pages
12-9issue
1eissn
2047-7724issn
2047-7732journal_volume
106pub_type
杂志文章abstract::Acanthamoeba keratitis is a painful and progressive infection of the cornea that can result in loss of vision. Here, for the first time in Pakistan, we report two cases of Acanthamoeba keratitis. The first patient was a 37-year-old female who presented with severe itching, redness, pain, along with loss of vision. The...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000124
更新日期:2014-01-01 00:00:00
abstract::Genetic control strategies aimed to bias the sex of progenies towards males present a promising new paradigm to eliminate malaria-transmitting mosquitoes. A synthetic sex-ratio distortion (SD) system was successfully engineered in Anopheles gambiae by exploiting the meiotic activity of the I-PpoI endonuclease targetin...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2020.1803628
更新日期:2020-10-01 00:00:00
abstract::Recent data strongly suggest an association between the current outbreak of ZIKA virus (ZIKV) in many countries of Central and South America and a sharp increase in the detection of microcephaly and fetal malformations. The link with brain defect, which has been detected mainly in some areas of Brazil, is supported by...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1080/20477724.2016.1234804
更新日期:2016-01-01 00:00:00
abstract:INTRODUCTION:Waste management through community mobilization to reduce breeding places at household level could be an effective and sustainable dengue vector control strategy in areas where vector breeding takes place in small discarded water containers. The objective of this study was to assess the validity of this a...
journal_title:Pathogens and global health
pub_type: 杂志文章,随机对照试验
doi:10.1179/2047773212Y.0000000060
更新日期:2012-12-01 00:00:00
abstract::Infection caused by intestinal parasites has significant public health consequences amongst children in the developing world. Street children are an under-studied group of society subjected to increased health risks when compared to their peers. To estimate the prevalence of intestinal parasitic infection and ascertai...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000073
更新日期:2013-03-01 00:00:00
abstract::Sand flies of Phlebotomus papatasi and P. sergenti are the main vectors of cutaneous leishmanisis (CL) in the old world. We aimed to screen Iranian P. papatasi and P. sergenti for their natural infections with Wolbachia and to determine their phylogenetic association with other species. Wolbachia surface protein (wsp)...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2018.1471438
更新日期:2018-05-01 00:00:00
abstract::Approximately 120 years ago the link between mosquito and the malaria transmission was discovered. However, even today it remains an open question whether the parasite is able to direct the blood-seeking and feeding behavior of its mosquito vector to maximize the probability of transmission. If the parasite has this a...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1080/20477724.2019.1703398
更新日期:2019-12-01 00:00:00
abstract::Trichomonas vaginalis is a flagellated protozoan parasite that infects the human urogenital tract, causing the most common non-viral, sexually transmitted disease worldwide. In this study, genetic variants of T. vaginalis were identified in Henan Province, China. Fragments of the small subunit of nuclear ribosomal RNA...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773215Y.0000000020
更新日期:2015-07-01 00:00:00
abstract:BACKGROUND:We aimed to identify challenges and to propose solutions for the implementation of tuberculosis (TB) programmes in rural Sub-Saharan Africa (SSA) by evaluating the outcomes of the TB programme in the Ancuabe district in rural Northern Mozambique. METHODS:Retrospective descriptive study of the patients inclu...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773215Y.0000000027
更新日期:2015-07-01 00:00:00
abstract::One of the essential steps in targeting tuberculosis (TB) intervention is early diagnosis and treatment of patients by reducing the reservoir of infection in the community. In the North-Eastern (NE) region of India pulmonary TB and paragonimiasis are overlapping public health issues. We performed a cross-sectional stu...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000086
更新日期:2013-04-01 00:00:00
abstract::We report a case of facultative intestinal myiasis due to larvae of the drone fly Eristalis tenax, also named the rat-tailed maggots. The development of larvae in the lower bowel was responsible for non-specific gastrointestinal symptoms that resembled ulcerative proctitis. The diagnosis was established upon the obser...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773214Y.0000000135
更新日期:2014-04-01 00:00:00
abstract::We previously attempted to identify 96 nonpolio enteroviruses (EVs) recovered in RD cell culture from children <15 years with acute flaccid paralysis in Nigeria. We succeeded in identifying 69 of the isolates. Here, we describe an attempt to identify the remaining 27 isolates. Twenty-six (the 27th isolate was exhauste...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2018.1548117
更新日期:2018-12-01 00:00:00
abstract::Neurocysticercosis has been recognized as a major cause of secondary epilepsy worldwide. So far, most of the knowledge about the disease comes from Latin America and the Indian subcontinent. Unfortunately, in sub-Saharan Africa the condition was neglected for a long time, mainly owing to the lack of appropriate diagn...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1179/2047773212Y.0000000047
更新日期:2012-09-01 00:00:00
abstract:INTRODUCTION:Acute hepatitis A is a worldwide public health problem especially in developing countries. Recently, a large, community-wide outbreak of hepatitis A occurred in the northeast part of Thailand. METHODS:Demographic and clinical data as well as blood samples were collected and analyzed from patients with acu...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000116
更新日期:2013-10-01 00:00:00
abstract::Immigration increases physical, mental, and social health problems. Emergency departments constitute resources that refugees can easily access and where they frequently present. Physicians from every specialty (chest diseases, thoracic surgery, internal diseases, etc.) may be consulted if needed. We aimed to compare d...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2021.1878442
更新日期:2021-01-24 00:00:00
abstract::Giardiasis is one of the commonest intestinal parasitic infections in Cuba. In order to determine care-seeking behaviour and diagnostic processes in paediatric in-patients with giardiasis, structured questionnaires were administered by interview mothers of children with giardiasis during January to December 2010. Duri...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773214Y.0000000152
更新日期:2014-09-01 00:00:00
abstract::The objective of this work is to compare the phenotypic and virulence genes characteristics in human and chicken isolates of Proteus mirabilis. The bacterial examination of 50 livers of individual broilers, marketed by four major outlets, revealed a high recovery of P. mirabilis (66%), and a low recovery frequency of ...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773212Y.0000000042
更新日期:2012-10-01 00:00:00
abstract::Crimean-Congo hemorrhagic fever (CCHF) is endemic in Turkey, with peak incidence of hospital admissions in the summer months. The aim of this pilot study was to evaluate the role of the severity grading score (SGS) in predicting length of hospital stay, laboratory usage, need for blood products, and hence total costs ...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2015.1136130
更新日期:2016-01-01 00:00:00
abstract:BACKGROUND:Visceral leishmaniasis (VL), also known as kala-azar in the Indian sub-continent (ISC), is a major public health concern in Bangladesh, India, and Nepal, where it is caused by Leishmania donovani transmitted by the sand fly Phlebotomus argentipes. Various ecological parameters including air temperature, rain...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1080/20477724.2016.1180775
更新日期:2016-05-01 00:00:00
abstract::In order to assess cardiac tolerance of halofantrine in children, we studied, retrospectively, 15 non complicated falciparum malaria cases treated with halofantrine, and focused on the effect on ventricular repolarisation. Our data showed that halofantrine can produce a moderate QTc prolongation without any life-thre...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773212Y.0000000007
更新日期:2012-05-01 00:00:00
abstract::Over 2 billion people in both developing as well as developed countries - over 30% of the world's population - are anaemic. With the classical preconception that oral iron administration or the intake of foods rich in iron increase haemoglobin concentration and reduce the prevalence of anaemia, specific programs have...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1179/2047773212Y.0000000043
更新日期:2012-08-01 00:00:00
abstract::Plasma levels of pro- and anti-inflammatory cytokines of Plasmodium falciparum-infected patients with severe malaria (SM; n = 62) and uncomplicated malaria (UM; n = 69) from Sri Lanka were assessed. SM patients had significantly higher levels of TNF-alpha (P < 0·01), IL-6 (P < 0·01), and IL-10 (P < 0·05) compared to t...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773212Y.0000000069
更新日期:2013-01-01 00:00:00
abstract::The second largest outbreak of Ebolavirus is currently ongoing in Eastern Democratic Republic of the Congo (DRC) and is characterized by lack of compliance with recommended control measures. Trusted local health agents, including medical students, may be valuable social mobilizers in this challenging context. We repor...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2020.1754654
更新日期:2020-05-18 00:00:00
abstract::Methicillin-resistant Staphylococcus aureus (MRSA) is one of the important pathogens worldwide showing resistance to several widely used antibiotics. This has made the treatment of MRSA infections harder, especially due to their prevalence in the hospital setting. We evaluated the antibiotic susceptibility patterns of...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2020.1827197
更新日期:2020-12-01 00:00:00
abstract::Anti-bacterial proteins in mosquitoes are known to play an important modulatory role on immune responses to infections with human pathogens including malaria parasites. In this study we characterized two members of the Anopheles gambiae Nimrod superfamily, namely AgNimB2 and AgEater. We confirm that current annotation...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/204777213X13867543472674
更新日期:2013-12-01 00:00:00
abstract::During the last decade, the chikungunya (CHIKV) virus has expanded its range of activity, conquering new territories and becoming an important global health threat. In particular, the challenge represented by the recent emergence of CHIKV in the Americas has strengthened the need of a safe and effective vaccine. Altho...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1179/2047773215Y.0000000017
更新日期:2015-06-01 00:00:00
abstract::Italy was initially one of the worse affected countries by the novel coronavirus (COVID-19). Medical students frequenting hospitals are more susceptible to be infected by the virus but also able to see the effects of the pandemic from the frontline. The aim of this study was to assess the COVID-19 related knowledge, b...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2021.1878447
更新日期:2021-01-31 00:00:00
abstract:BACKGROUND:The prevalence of sickle cell disease (SCD) is extremely high in the Democratic Republic of Congo (DRC). Despite the high prevalence of this disease in our midst, there has been no report on the clinical features in the sickle cell pediatric population suffering from malaria in our midst. METHODS:A retrospe...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1179/2047773213Y.0000000089
更新日期:2013-06-01 00:00:00
abstract::The aim of this study was to describe the clinical and epidemiological profile of immunosuppressed patients with imported strongyloidiasis in a non-endemic setting, and to compare these results with non-immunosuppressed patients. This is a case-control substudy from a larger observational retrospective study that incl...
journal_title:Pathogens and global health
pub_type: 杂志文章
doi:10.1080/20477724.2020.1857491
更新日期:2020-12-30 00:00:00
abstract::Eastern Europe (EE) has been severely affected by mosquito-borne viruses (moboviruses). In this review, we summarize the epidemiology of moboviruses, with particular attention to West Nile virus (WNV). The study of WNV human cases in EE between 2010 and 2016, revealed that the epidemiology of WNV in EE is complex with...
journal_title:Pathogens and global health
pub_type: 杂志文章,评审
doi:10.1080/20477724.2018.1483567
更新日期:2018-07-01 00:00:00