Bovine lactoferrin-derived peptides as novel broad-spectrum inhibitors of influenza virus.

Abstract:

:Bovine lactoferrin (bLf) is a multifunctional glycoprotein that plays an important role in innate immunity against infections, including influenza. Here we have dissected bLf into its C- and N-lobes and show that inhibition of influenza virus hemagglutination and cell infection is entirely attributable to the C-lobe and that all major virus subtypes, including H1N1 and H3N2, are inhibited. By far-western blotting and sequencing studies, we demonstrate that bLf C-lobe strongly binds to the HA(2) region of viral hemagglutinin, precisely the highly conserved region containing the fusion peptide. By molecular docking studies, three C-lobe fragments were identified which inhibited virus hemagglutination and infection at fentomolar concentration range. Besides contributing to explain the broad anti-influenza activity of bLf, our findings lay the foundations for exploiting bLf fragments as source of potential anti-influenza therapeutics.

journal_name

Pathog Glob Health

authors

Ammendolia MG,Agamennone M,Pietrantoni A,Lannutti F,Siciliano RA,De Giulio B,Amici C,Superti F

doi

10.1179/2047773212Y.0000000004

subject

Has Abstract

pub_date

2012-03-01 00:00:00

pages

12-9

issue

1

eissn

2047-7724

issn

2047-7732

journal_volume

106

pub_type

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