Projective simulation for artificial intelligence.

abstract：:We investigated the relationship between aqueous cytokine levels, changes in ocular blood flow, and morphological and functional improvements after intravitreal ranibizumab injection (IRI) in treatment-naïve eyes with center-involving diabetic macular edema (DME). Thirty-three eligible patients with DME (33 eyes) were...

journal_title：Scientific reports

authors： Mizui T,Noma H,Yasuda K,Kanemaki T,Goto H,Shimura M

更新日期：2020-12-10 00:00:00

abstract：:Dietary modulation of the gut microbiota impacts human health. Here we investigated the hitherto unknown effects of resistant starch type 4 (RS4) enriched diet on gut microbiota composition and short-chain fatty acid (SCFA) concentrations in parallel with host immunometabolic functions in twenty individuals with signs...

journal_title：Scientific reports

authors： Upadhyaya B,McCormack L,Fardin-Kia AR,Juenemann R,Nichenametla S,Clapper J,Specker B,Dey M

更新日期：2016-06-30 00:00:00

abstract：:By employing a single AlGaN layer with low Al composition, high quality and uniformity AlGaN/GaN heterostructures have been successfully grown on Si substrates by metal-organic chemical vapor deposition (MOCVD). The heterostructures exhibit a high electron mobility of 2150 cm(2)/Vs with an electron density of 9.3 × 10...

journal_title：Scientific reports

authors： Cheng J,Yang X,Sang L,Guo L,Zhang J,Wang J,He C,Zhang L,Wang M,Xu F,Tang N,Qin Z,Wang X,Shen B

更新日期：2016-03-10 00:00:00

abstract：:Analyzing heart rate variability (HRV) in preterm infants can help track maturational changes and subclinical signatures of disease. We conducted an observational study to characterize the effect of demographic and cardiorespiratory factors on three features of HRV using a linear mixed-effects model. HRV-features were...

journal_title：Scientific reports

authors： Joshi R,Kommers D,Guo C,Bikker JW,Feijs L,van Pul C,Andriessen P

更新日期：2019-05-22 00:00:00

abstract：:Serotype-cross-reactive memory T cells responding to secondary dengue virus (DENV) infection are thought to contribute to disease. However, epitope-specific T cell responses have not been thoroughly compared between subjects with primary versus secondary DENV infection. We studied CD8(+) T cells specific for the HLA-A...

journal_title：Scientific reports

authors： Friberg H,Bashyam H,Toyosaki-Maeda T,Potts JA,Greenough T,Kalayanarooj S,Gibbons RV,Nisalak A,Srikiatkhachorn A,Green S,Stephens HA,Rothman AL,Mathew A

更新日期：2011-01-01 00:00:00

abstract：:Carcinomas constitute over 80% of all human cancer types with no effective therapy for metastatic disease. Here, we demonstrate, for the first time, the efficacy of therapeutic-ultrasound (TUS) to deliver a human tumor suppressor gene, hSef-b, to prostate tumors in vivo. Sef is downregulated in various human carcinoma...

journal_title：Scientific reports

authors： Mishel S,Shneyer B,Korsensky L,Goldshmidt-Tran O,Haber T,Machluf M,Ron D

更新日期：2017-11-08 00:00:00

abstract：:The stochastic tunneling-basin hopping method (STUN-BH) was utilized to obtain the most stable peptide S7 configuration (Ac-Ser-Ser-Phe-Pro-Gln-Pro-Asn-CONH2) adsorbed on Au(111) facet. After the most stable S7 configuration was found, molecular dynamics (MD) simulation was conducted to investigate the thermal stabili...

journal_title：Scientific reports

authors： Lin CH,Ju SP,Su JW,Li DE

更新日期：2020-02-07 00:00:00

abstract：:Functional imaging has become an important tool in oncology because it not only provides information about the size and localization of the tumour, but also about the pathophysiological features of the tumoural cells. One of the characteristic features of some tumour types is that their fast growth leads to deficient ...

journal_title：Scientific reports

authors： Iglesias P,Penas C,Barral-Cagiao L,Pazos E,Costoya JA

更新日期：2019-05-08 00:00:00

abstract：:This study aimed to develop and validate a model for the preoperative prediction of the effectiveness of hysteroscopic resection of a uterine cesarean niche in patients with postmenstrual spotting. The predictive model was developed in a primary prospective cohort consisting of 208 patients with niche treated by hyste...

journal_title：Scientific reports

authors： Zhu Q,He X,Jiang L,Liang G,Zhu C,Pan H,Zhang J,Huirne JA

更新日期：2020-10-15 00:00:00

abstract：:Analysis of volatile organic compounds (VOCs) is a promising approach for non-invasive, fast and potentially inexpensive diagnostics. Here, we present a new methodology for profiling the body chemistry by using the volatile fraction of molecules in various body fluids. Using mass spectrometry and cross-reactive nanoma...

journal_title：Scientific reports

authors： Broza YY,Zuri L,Haick H

更新日期：2014-04-09 00:00:00

abstract：:Malaria has steadily increased in the Peruvian Amazon over the last five years. This study aimed to determine the parasite prevalence and micro-geographical heterogeneity of Plasmodium vivax parasitaemia in communities of the Peruvian Amazon. Four cross-sectional active case detection surveys were conducted between Ma...

journal_title：Scientific reports

authors： Carrasco-Escobar G,Gamboa D,Castro MC,Bangdiwala SI,Rodriguez H,Contreras-Mancilla J,Alava F,Speybroeck N,Lescano AG,Vinetz JM,Rosas-Aguirre A,Llanos-Cuentas A

更新日期：2017-08-14 00:00:00

abstract：:Dye-sensitised solar cells (DSCs) are a promising substitute for conventional silicon solar cells. A scattering layer of submicrometer pores or particles has been widely introduced to achieve a high light-harvesting efficiency. However, many such fabrication processes require high temperatures and multiple steps to pr...

journal_title：Scientific reports

authors： Ha SJ,Moon JH

更新日期：2014-07-09 00:00:00

abstract：:We set out to determine the usability of serum neurofilament light chain (sNfL), serum glial fibrillary acidic protein (sGFAP), and retinal parameters by using optical coherence tomography (OCT) as reliable biomarkers of the progression of oxaliplatin-induced peripheral neuropathy (OIPN). Forty-three patients schedule...

journal_title：Scientific reports

authors： Kim SH,Choi MK,Park NY,Hyun JW,Lee MY,Kim HJ,Jung SK,Cha Y

更新日期：2020-05-14 00:00:00

abstract：:Early antiretroviral therapy (ART) initiation is a recommended public health approach for the prevention of HIV-1 transmission. In this cohort study, we included 13132 serodiscordant couples. ART was initiated for patients with CD4+ T cell counts less than 200 cells/uL, 350 cells/uL, and 500 cells/uL respectively. Thi...

journal_title：Scientific reports

authors： Liu P,Tang Z,Lan G,Zhu Q,Chen H,You Y,Yang X,Liang S,Chen Y,Xing H,Liao L,Feng Y,Shen Z,Ruan Y,Shao Y

更新日期：2018-02-21 00:00:00

abstract：:The N-methyl-D-aspartate subfamily of ionotropic glutamate receptors (NMDARs) is well known for its important roles in the central nervous system (CNS), e.g. learning and memory formation. Besides the CNS, NMDARs are also expressed in numerous peripheral tissues including the pancreas, kidney, stomach, and blood cells...

journal_title：Scientific reports

authors： Koch A,Bonus M,Gohlke H,Klöcker N

更新日期：2019-07-11 00:00:00

abstract：:MicroRNA (miRNA) regulates gene expression by binding to specific sites in the 3'untranslated regions of its target genes. Machine learning based miRNA target prediction algorithms first extract a set of features from potential binding sites (PBSs) in the mRNA and then train a classifier to distinguish targets from no...

journal_title：Scientific reports

authors： Bandyopadhyay S,Ghosh D,Mitra R,Zhao Z

更新日期：2015-01-23 00:00:00

abstract：:Alcohol consumption before or during pregnancy poses serious health risks to the fetus; however, the underlying mechanisms involved remain obscure. Here, we investigated whether ethanol consumption before pregnancy affects maternal or fetal health and whether pharmacological inhibition of CYP2E1, a major ethanol oxida...

journal_title：Scientific reports

authors： Lee YJ,Kim JY,Lee DY,Park KJ,Kim GH,Kim JE,Roh GS,Lim JY,Koo S,Lim NK,Park HY,Kim WH

更新日期：2020-06-22 00:00:00

abstract：:Colorectal cancer (CRC) treatment is associated with a high morbidity which may result in a reduced health-related quality of life (HRQoL). The pre-operative measurement of handgrip strength (HGS) might be a tool to predict the patient's outcome after CRC surgery. The aim of this study was to evaluate the association ...

journal_title：Scientific reports

authors： van Heinsbergen M,Konsten JL,Bours MJL,Bouvy ND,Weijenberg MP,Janssen-Heijnen ML

更新日期：2020-08-03 00:00:00

abstract：:Immune parameters show characteristic normal baseline levels and variance in the population. We characterised the degree of inter-individual and within-individual variation over one-year time period in 33 immune cell subsets by flow cytometry in peripheral blood mononuclear cells from 43 healthy young adult volunteers...

journal_title：Scientific reports

authors： Kanodia P,Kaur G,Coshic P,Chatterjee K,Neeman T,George A,Rath S,Bal V,Prabhu SB

更新日期：2019-10-14 00:00:00

abstract：:An amendment to this paper has been published and can be accessed via a link at the top of the paper. ...

journal_title：Scientific reports

authors： Kamath PL,Manlove K,Cassirer EF,Cross PC,Besser TE

更新日期：2020-04-22 00:00:00

abstract：:Grain size is an important trait influencing both the yield and quality of rice and its major determinant is glume size. However, how glume size is regulated remains largely unknown. Here, we report the characterization of OsKinesin-13A, which regulates cell elongation and glume length in rice. The mutant of OsKinesin...

journal_title：Scientific reports

authors： Deng ZY,Liu LT,Li T,Yan S,Kuang BJ,Huang SJ,Yan CJ,Wang T

更新日期：2015-03-25 00:00:00

abstract：:An atmospheric component of the Philippine-Taiwan Oscillations (PTOa) is used to examine its potential connection with tropical cyclone (TC) frequency in the western North Pacific in the period of 1979-2014. During positive PTOa years, more TCs are observed in the tropical western Pacific south of 18 °N where cyclonic...

journal_title：Scientific reports

authors： Chang YK,Miyazawa Y,Kodaira T,Behera S

更新日期：2018-11-29 00:00:00

abstract：:Pantoea sp. IMH is the only bacterium found in genus Pantoea with a high As resistance capacity, but its molecular mechanism is unknown. Herein, the organization, function, and evolution of ars genes in IMH are studied starting with analysis of the whole genome. Two ars systems - ars1 (arsR1B1C1H1) and ars2 (arsR2B2C2...

journal_title：Scientific reports

authors： Wang L,Zhuang X,Zhuang G,Jing C

更新日期：2016-12-14 00:00:00

abstract：:L-arginine:glycine amidinotransferase (AGAT) and its metabolites creatine and homoarginine (HA) have been linked to cardiovascular pathologies in both human and murine studies, but the underlying molecular mechanisms are poorly understood. Here, we report the first analysis of heart transcriptome variation using micro...

journal_title：Scientific reports

authors： Jensen M,Müller C,Choe CU,Schwedhelm E,Zeller T

更新日期：2020-03-16 00:00:00

abstract：:Transcript levels are the primary factor determining protein levels, but for the majority of genes, fold changes in transcript levels are larger than the corresponding changes in protein levels, a phenomenon that is termed "protein homeostasis". However, this phenomenon is not well characterized in the context of envi...

journal_title：Scientific reports

authors： Sun Y,Wen J,Chen R,Deng Y

更新日期：2019-05-24 00:00:00

abstract：:FMS-like tyrosine kinase 3 (FLT3) is a key driver of acute myeloid leukemia (AML). Several tyrosine kinase inhibitors (TKIs) targeting FLT3 have been evaluated clinically, but their effects are limited when used in monotherapy due to the emergence of drug-resistance. Thus, a better understanding of drug-resistance pat...

journal_title：Scientific reports

authors： Morales ML,Arenas A,Ortiz-Ruiz A,Leivas A,Rapado I,Rodríguez-García A,Castro N,Zagorac I,Quintela-Fandino M,Gómez-López G,Gallardo M,Ayala R,Linares M,Martínez-López J

更新日期：2019-12-09 00:00:00

abstract：:Pitch is a complex hearing phenomenon that results from elicited and self-generated cochlear vibrations. Read-off vibrational information is relayed higher up the auditory pathway, where it is then condensed into pitch sensation. How this can adequately be described in terms of physics has largely remained an open que...

journal_title：Scientific reports

authors： Martignoli S,Gomez F,Stoop R

更新日期：2013-01-01 00:00:00

abstract：:Multi-atlas-based segmentation (MAS) methods have demonstrated superior performance in the field of automatic image segmentation, and label fusion is an important part of MAS methods. In this paper, we propose a label fusion method that incorporates pixel greyscale probability information. The proposed method combines...

journal_title：Scientific reports

authors： Wang M,Li P

更新日期：2019-11-29 00:00:00

abstract：:As an AAA-ATPase, Vps4 is important for function of multivesicular bodies (MVB) sorting pathway, which involves in cellular phenomena ranging from receptor down-regulation to viral budding to cytokinesis. The activity of Vps4 is stimulated by the interactions between Vta1 N-terminus (named as Vta1NTD) and Did2 fragmen...

journal_title：Scientific reports

authors： Shen J,Yang Z,Wang J,Zhao B,Lan W,Wang C,Zhang X,Wild CJ,Liu M,Xu Z,Cao C

更新日期：2016-12-07 00:00:00

abstract：:Ceramide, a bioactive lipid and signaling molecule associated with cardiovascular disease, is known to activate extracellular signal regulated kinases 1 and 2 (ERK1/2). Here, we determined that the effect of ceramide on ERK1/2 is mediated by ceramide signaling on an ERK scaffold protein, IQ motif containing GTPase act...

journal_title：Scientific reports

authors： Vetterkind S,Lin QQ,Morgan KG

更新日期：2017-08-24 00:00:00