Alteration of MMP-2 and -14 expression by imatinib in HPV-positive and -negative squamous cell carcinoma.

abstract：:The p53 tumor suppressor is a transcription factor that regulates cell cycle and apoptosis in response to a variety of environmental stress conditions. Recent studies indicated that the apoptotic protease activating factor-1 (Apaf-1) is a direct transcriptional target of p53 in DNA damage-induced apoptosis. However, t...

journal_title：Oncology reports

authors： Ho CK,Bush JA,Li G

更新日期：2003-09-01 00:00:00

abstract：:The present study was performed to investigate the protective effects of tannic acid (TA) on liver injury induced by arsenic trioxide (ATO) and to elucidate the mechanism involved as related to the Kelch‑like ECH‑associated protein 1 (Keap1)‑nuclear factor erythroid 2‑related factor 2 (Nrf2)/antioxidant response eleme...

journal_title：Oncology reports

authors： Li M,Liu P,Xue Y,Liang Y,Shi J,Han X,Zhang J,Chu X,Chu L

更新日期：2020-11-01 00:00:00

abstract：:Livistona chinensis seeds have been used for centuries to clinically treat various types of cancer. Our published data suggest that Livistona chinensis seeds are able to inhibit hepatocellular carcinoma (HCC) growth in vitro and in vivo via promotion of mitochondrial-dependent apoptosis. To further elucidate the molec...

journal_title：Oncology reports

authors： Lin W,Zhao J,Cao Z,Zhuang Q,Zheng L,Zeng J,Hong Z,Peng J

更新日期：2014-04-01 00:00:00

abstract：:The present study investigated the effect of macrophage colony-stimulating factor (M-CSF) on the immune functions and blood cell counts of patients with ovarian carcinoma receiving cytotoxic chemotherapy (CTX). Seventy-five consecutive patients with white blood cell counts less than 3,000/microl after CTX were randoml...

journal_title：Oncology reports

authors： Shimizu Y,Utsugi K,Umezawa S,Shimizu K,Hasumi K,Suzuki M,Takaku F

更新日期：2001-07-01 00:00:00

abstract：:It has been shown that deguelin, one of the compounds of rotenoids from flavonoid family, induced cytotoxic effects through induction of cell cycle arrest and apoptosis in many types of human cancer cell lines, but deguelin-affected DNA damage and repair gene expression (mRNA) are not clarified yet. We investigated th...

journal_title：Oncology reports

authors： Ji BC,Yu CC,Yang ST,Hsia TC,Yang JS,Lai KC,Ko YC,Lin JJ,Lai TY,Chung JG

更新日期：2012-04-01 00:00:00

abstract：:The aim of the present study was to investigate the role of miR‑203a‑3p in colorectal cancer (CRC) and identify the target gene of microRNA (miR)‑203a‑3p. A total of 59 sets of cancer tissues and corresponding adjacent non‑tumor tissues were collected from CRC patients (aged 31‑78 years) between October 2016 and May 2...

journal_title：Oncology reports

authors： Qian Z,Gong L,Mou Y,Han Y,Zheng S

更新日期：2019-11-01 00:00:00

abstract：:Alterations in DNA methylation have a central role in the development and outcome of most human malignancies. Non‑small cell lung cancer (NSCLC), the most common lung cancer, leads to the largest number of cancer‑related deaths worldwide. FBJ murine osteosarcoma viral oncogene homolog B (FOSB) is a key component of th...

journal_title：Oncology reports

authors： Kim DS,Lee WK,Park JY

更新日期：2020-02-01 00:00:00

abstract：:We aimed to investigate the relationship between miRNA-146a and latent membrane protein 1 (LMP1) of Epstein-Barr virus (EBV) in nasopharyngeal carcinoma (NPC). The expression levels of LMP1 in 40 cases of NPC, 28 cases of chronic nasopharyngitis and NPC cell lines CNE1 and CNE1-GL (...

journal_title：Oncology reports

authors： Zhao Y,Chen X,Jing M,Du H,Zeng Y

更新日期：2012-10-01 00:00:00

abstract：:Chronic hepatitis B virus (HBV) infection is a leading cause of liver cirrhosis and cancer. Among the pathogenic factors of HBV, HBV X protein (HBx) is attracting increased attention. Although it is documented that HBx is a multifunctional regulator that modulates cell inflammation and apoptosis, the exact mechanism r...

journal_title：Oncology reports

authors： Gao WY,Li D,Cai DE,Huang XY,Zheng BY,Huang YH,Chen ZX,Wang XZ

更新日期：2017-01-01 00:00:00

abstract：:Recent studies have shown that miRNAs have potent abilities to activate gene expression by targeting promoter elements, a phenomenon known as RNA activation (RNAa). In the present study, we identified a new endogenous miR-3619-5p which was decreased in prostate cancer tissues and cells compared to corresponding normal...

journal_title：Oncology reports

authors： Li S,Wang C,Yu X,Wu H,Hu J,Wang S,Ye Z

更新日期：2017-01-01 00:00:00

abstract：:Matrix metalloproteinases (MMPs) and their tissue inhibitors (TIMPs) are involved in tumor invasion, but their prognostic significance is still under discussion. We set out to analyze the epithelial and stromal expression of MMP-2, MMP-7, MMP-9, MT1-MMP, TIMP-1 and TIMP-2 in advanced epithelial ovarian cancers and to ...

journal_title：Oncology reports

authors： Brun JL,Cortez A,Lesieur B,Uzan S,Rouzier R,Daraï E

更新日期：2012-04-01 00:00:00

abstract：:Given its tumor-specific expression, including liver cancer, OY-TES-1 is a potential molecular marker for the diagnosis and immunotherapy of liver cancers. However, investigations of the mechanisms and the role of OY-TES-1 in liver cancer are rare. In the present study, based on a comprehensive bioinformatic analysis ...

journal_title：Oncology reports

authors： Hu Q,Fu J,Luo B,Huang M,Guo W,Lin Y,Xie X,Xiao S

更新日期：2015-04-01 00:00:00

abstract：:Ribonucleotide reductase M2 subunit (RRM2) is one of the two subunits of human ribonucleotide reductase which plays a critical role in tumor progression. The aim of the present study was to analyze its expression, clinical significance and biological functions in gastric adenocarcinoma. We observed the upregulation of...

journal_title：Oncology reports

authors： Kang W,Tong JH,Chan AW,Zhao J,Wang S,Dong Y,Sin FM,Yeung S,Cheng AS,Yu J,To K

更新日期：2014-06-01 00:00:00

abstract：:Treatment of patients affected by advanced or inoperable GIST was revolutionized by the use of the tyrosine kinase inhibitors. Despite the fact that most patients have a good durable response of disease, they develop a resistance to treatments after a median time of 24 months. The acquired resistance is an emerging as...

journal_title：Oncology reports

authors： Maleddu A,Pantaleo MA,Nannini M,Di Battista M,Saponara M,Lolli C,Biasco G

更新日期：2009-06-01 00:00:00

abstract：:Oncolytic viruses have emerged as a novel class of potent anticancer agents offering an improvement on chemo- and radiotherapy in terms of tumor targeting and reduction of side-effects. Among these agents, autonomous parvoviruses have attracted the attention of researchers for their ability to preferentially replicate...

journal_title：Oncology reports

authors： Raykov Z,Grekova S,Galabov AS,Balboni G,Koch U,Aprahamian M,Rommelaere J

更新日期：2007-06-01 00:00:00

abstract：:Esophageal carcinosarcoma (ECS) is a rare malignant neoplasm associated with a poor patient prognosis. It is characterized by the presence of both malignant epithelial and mesenchymal components. Molecular-targeted therapy of several receptor tyrosine kinases (RTKs) has been reported to be effective in the treatment o...

journal_title：Oncology reports

authors： Sano A,Sakurai S,Kato H,Suzuki S,Yokobori T,Sakai M,Tanaka N,Inose T,Sohda M,Nakajima M,Fukai Y,Miyazaki T,Ojima H,Hosoya Y,Enomoto T,Kanda T,Ajioka Y,Kuwano H

更新日期：2013-06-01 00:00:00

abstract：:The effects of a novel oral fluoropyrimidine derivative S-1 on peritoneal metastasis from gastric cancer were investigated. OCUM-2MD3 cells, a highly peritoneal-metastatic cell line, were injected intraperitoneally in nude mice. These mice were allocated to the following three groups (each group, n=10): the S-1 group,...

journal_title：Oncology reports

authors： Yamagata S,Nakata B,Hirakawa K

更新日期：2004-11-01 00:00:00

abstract：:The purpose of this study was to examine the effects of irradiation by 125I seeds in human lung cancer xenograft model and to determine the underlying mechanisms involved, with a focus on angiogenesis. A group of 40 mice bearing A549 lung adenocarcinoma xenografts was randomly separated into 4 groups: control group (n...

journal_title：Oncology reports

authors： Xiang GL,Zhu XH,Lin CZ,Wang LJ,Sun Y,Cao YW,Wang FF

更新日期：2017-05-01 00:00:00

abstract：:The tumor necrosis factor receptor (TNFR)-associated factor 4 (TRAF4) is a member of TRAF family proteins that act as major signal transducers of the TNF receptor and the interleukin-1 receptor/Toll-like receptor (IL-1R/TLR) superfamily. TRAF4 has been reported to be overexpressed in various human cancers. However, th...

journal_title：Oncology reports

authors： Ahmed F,Shiraishi T,Vessella RL,Kulkarni P

更新日期：2013-12-01 00:00:00

abstract：:Despite significant advances in micro-metastasis detection methods, little is known about the relationship between micro-metastasis and primary tumors. The purpose of this study was to assess the ability of expression of the breast cancer-related markers, HER-2/neu, COX-2, VEGF and PDGF-B, as a predictor for micro-met...

journal_title：Oncology reports

authors： Zhu L,Loo WT,Cheng CW,Chow LW

更新日期：2006-05-01 00:00:00

abstract：:Fluoroquinolones affect the proliferation and apoptotic cell death of several human malignancies. Therefore, we investigated whether new 6-aminoquinolone derivatives, initially synthesized as anti-HIV agents, could affect the proliferation and apoptotic cell death of human prostate cancer cell lines. PC3 and LNCaP cel...

journal_title：Oncology reports

authors： Minelli A,Bellezza I,Siciliano E,Liguori L,Tabarrini O,Cecchetti V,Fravolini A

更新日期：2005-06-01 00:00:00

abstract：:Cervical cancer is the second most commonly diagnosed cancer in women. Novel prognostic biomarkers are required to predict the progression of cervical cancer. Cervical cancer expression data were obtained from The Cancer Genome Atlas (TCGA) database. MicroRNAs (miRNAs) significantly differentially expressed between ea...

journal_title：Oncology reports

authors： Shi C,Yang Y,Zhang L,Zhang T,Yu J,Qin S,Gao Y

更新日期：2019-06-01 00:00:00

abstract：:Nuclear factor (NF)-κB is the key transcription factor involved in the inflammatory responses, and its activation aggravates tumors. Peptidoglycan (PGN), a main cell wall component of Gram-positive bacteria, stimulates Toll-like receptor 2 (TLR-2) and activates a number of inflammat...

journal_title：Oncology reports

authors： Echigo R,Sugimoto N,Yachie A,Ohno-Shosaku T

更新日期：2012-10-01 00:00:00

abstract：:In breast cancer, neuregulin-1 (NRG1) is known as a ligand for the HER3 receptor, which has no intrinsic tyrosine kinase activity. When activated by NRG1 binding, the HER3 receptor forms a heterodimer with other HER family receptors and mediates downstream signaling pathways, leading to multiple effects including grow...

journal_title：Oncology reports

authors： Jeong H,Kim J,Lee Y,Seo JH,Hong SR,Kim A

更新日期：2014-09-01 00:00:00

abstract：:We previously reported that chromosome arm 10q is one of the target regions of allelic loss in human endometrial cancer. To identify the gene in this region responsible for endometrial cancer, we further characterized this region and localized the hBRAG gene. The function of hBRAG has not yet been fully studied, and t...

journal_title：Oncology reports

authors： Yuki M,Yoshinaga K,Yamakawa H,Sakurada K,Sato S,Yajima A,Horii A

更新日期：2000-11-01 00:00:00

abstract：:Inflammation is regarded as one of the major hallmarks of tumors, and has a very close relationship with gastric cancer. Interleukin-33 (IL-33), a new member of the IL-1 family, plays an important role in both inflammatory disease and tumors. The present study was designed to explore the effects of IL-33 on the prolif...

journal_title：Oncology reports

authors： Ye XL,Zhao YR,Weng GB,Chen YC,Wei XN,Shao JP,Ji H

更新日期：2015-06-01 00:00:00

abstract：:As a common malignancy of the endocrine system, papillary thyroid carcinoma (PTC) seriously affects the quality of life of patients. lncRNA PAX8‑AS1:28, or lnc‑PSD4‑1:14 has been reported to be abnormally expressed in PTC. However, the function of PAX8‑AS1:28 in PTC is still unknown. Therefore, the present study aimed...

journal_title：Oncology reports

authors： Zhang Y,Li F,Chen J

更新日期：2019-04-01 00:00:00

abstract：:Although chemotherapy is initially effective in debulking tumor mass in a number of different types of malignancy, tumor cells gradually acquire chemoresistance and frequently progress to advanced clinical stage. Accumulating evidence has indicated that the tumor sensitivity to several chemotherapeutic drugs is regula...

journal_title：Oncology reports

authors： Tomita R,Sasabe E,Tomomura A,Yamamoto T

更新日期：2020-11-01 00:00:00

abstract：:The usefulness of the in vitro chemosensitivity test, the collagen gel droplet embedded culture drug- sensitivity test (CD-DST, Int J Oncol 11: 449, 1997), in cisplatin-based combined chemotherapy for postoperative recurrent tumors in non-small cell lung cancer (NSCLC) patients was retrospectively analyzed. CD-DST dat...

journal_title：Oncology reports

authors： Higashiyama M,Kodama K,Yokouchi H,Takami K,Nakagawa H,Imamura F,Minamigawa K,Kobayashi H

更新日期：2001-03-01 00:00:00

abstract：:Breast cancer is one of the most common malignancies diagnosed in women and it is increasing in incidence. Siegesbeckia glabrescens (SG) has been used in traditional oriental medicine to treat cardiovascular diseases such as hypertension and angina pectoris. This study examined whether or not SG could induce apoptosis...

journal_title：Oncology reports

authors： Jun SY,Choi YH,Shin HM

更新日期：2006-06-01 00:00:00