Abstract:
:A 50-year-old male patient demonstrated an existing left proptosis for several weeks. The patient was suffering from physical exhaustion and had lost considerable weight. Furthermore, we observed greatly enlarged parotid and submandibular glands on both sides. MRI of the neck showed multiple, sharply circumscribed lesions in the major salivary glands and both lacrimal glands as well as in the orbit. Initially we suspected Heerfordt's syndrome, a manifestation of sarcoidosis, but laboratory diagnosis could not reveal a pathological erythrocyte sedimentation rate or an increased ACE titer. After exploratory excision from the right submandibular gland, histological examination revealed Castleman's disease. Therefore, we initiated an immunomodulatory therapy with interleukin-6 receptor antagonists.Castleman's disease is one of the very rare, benign, lymphoproliferative processes that have a tendency to turn malignant. Isolated findings of Castleman's disease should be completely resected. There are no clear treatment strategies for multiple localizations of Castleman's disease. The approaches range from systemic glucocorticoid therapy with chemotherapy to immunomodulatory treatment. In contrast to isolated findings, the prognosis for multicentric occurrence is unfavorable.
journal_name
HNOjournal_title
HNOauthors
Hirt R,Krause U,Knipping Sdoi
10.1007/s00106-012-2522-1subject
Has Abstractpub_date
2012-12-01 00:00:00pages
1123-6issue
12eissn
0017-6192issn
1433-0458journal_volume
60pub_type
杂志文章相关文献
HNO文献大全abstract::To investigate the dynamic properties of human hearing, experiments in vivo and with cadaver specimens can be carried out. Furthermore, electrical or mechanical models can also be used to study specific phenomena and parameter sensitivities. Present electrical and mechanical models are often based on crude structural ...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1994-12-01 00:00:00
abstract::From a series of 35 cases with intraoperative monitoring of acoustic evoked brainstem responses 4 cases with cerebellopontine angle surgery are presented in detail. The aim of neuromonitoring is to provide the surgeon with an additional instrument to assess the functional state of the hearing pathway with objective ne...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1985-11-01 00:00:00
abstract::Symmetric, sometimes monstrous fat deposits occur in this rare benign disease. They can extend from the neck to the shoulders and from the mandible to the clavicle. The authors have treated 3 patients during the last 4 years. One of them was sent as an inpatient with the diagnosis of lymphadenitis. The aetiology is un...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1984-09-01 00:00:00
abstract::Failed intubation in three patients is reported. All three patients suffered sudden, extreme impaired of mask-ventilation. Twice a coniotomy with subsequent tracheostomy proved to be life saving and without permanent injury. In the other patient tracheostomy had been attempted without success, and subsequent, successf...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1987-10-01 00:00:00
abstract:OBJECTIVES:Cerebellopontine angle tumors, although uniform in location, are diverse with regard to the site of tumor origin and displacement of the neurovascular structures. With the increasing use of magnetic resonance imaging in the diagnosis of brain lesions, the treatment of tumors of the cerebellopontine angle has...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-002-0797-3
更新日期:2003-04-01 00:00:00
abstract::Orbital complications of various pathogenesis include impairment or loss of vision inhibition of globe motility and exophthalmos, and are treated best by an interdisciplinary team. Preoperative strategy should include information about underlying diseases, since success of treatment is related to diagnosis. To analyse...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1994-11-01 00:00:00
abstract::We describe a 36 year old man who underwent three Caldwell-Luc operations during a five year period. Following the first operation, a persistent induration of the cheek was noted, and was found to be sarcoidosis histologically after the third operation. Since sarcoidosis is uncommonly found in the region of the maxill...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1981-03-01 00:00:00
abstract::During recent decades, the clinical use of botulinum toxin has become increasingly well established. In the field of otorhinolaryngology there are many indications for which botulinum toxin can improve patients' quality of life. These include applications in the region of the head and neck muscles and the autonomic ne...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-017-0409-x
更新日期:2017-10-01 00:00:00
abstract::Extracranial meningiomas are rare tumors of the lateral skull base. A 37-year-old woman presented with tinnitus und progressive hearing loss of her right ear. A painful mass lesion was also palpable in her mandibular angle. CT and MRI scans revealed an intracranial mass with extension to the lateral skull base. These ...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s001060050358
更新日期:1999-01-01 00:00:00
abstract:BACKGROUND:Recurrent exacerbation of chronic external otitis represents a special challenge for the attending physician. The goal of our study was to evaluate the effectiveness of novel topical immunomodulators acting through an anti-inflammatory, nonsteroidal mechanism. PATIENTS AND METHODS:In a prospective study, in...
journal_title:HNO
pub_type: 临床试验,杂志文章
doi:10.1007/s00106-007-1615-8
更新日期:2008-05-01 00:00:00
abstract::Obstructive sleep apnea (OSA) has a relatively high prevalence of 3-7% in the general population in western industrialized countries. The prevalence is higher in older patients and in patients with cardiac or metabolic disorders. In the general surgical population patients with OSA are often unrecognized prior to surg...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-012-2495-0
更新日期:2012-04-01 00:00:00
abstract::Granuloma gangraenescens is placed between Wegener's granulomatosis and reticulum cell sarcoma. It is very difficult to diagnose due to absence of early symptoms as in this reported case, which was diagnosed histologically and which temporally responded to steroids and Imurek. Change histologically to a reticulum cell...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1976-01-01 00:00:00
abstract:INTRODUCTION:The therapy of choice in nasoseptal defects is reconstruction with vital respiratory mucosa; in particular, three-layer repair using the bridge-flap technique according to Schultz-Coulon is the most promising. Cases exceeding operative limitations can be treated with silastic buttons. Our aim was to overco...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-009-2072-3
更新日期:2010-04-01 00:00:00
abstract::Transtympanic electrocochleography (ECoG) enables auditory evoked potentials to be recorded directly from the peripheral organ, and ECoG recordings can be used as a routine during operations. Examples of cochlear and eighth nerve monitoring in middle ear, inner ear, and cerebellopontine angle surgery are given. This m...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1992-04-01 00:00:00
abstract::Despite recent advances in radiochemotherapy, treatment of locally advanced head and neck squamous cell carcinoma is still challenging, and survival rates have improved only slightly. This is due to the high frequency of metastases and local and/or regional tumor recurrences that have acquired radio- or chemoresistanc...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-015-0111-9
更新日期:2016-05-01 00:00:00
abstract::A retrospective study of 24 children suffering from nasopharyngeal cancer (NPC) during the years 1974-1983 is reported. The diagnosis was delayed because of the primary tumor site and difficulty in examination. Cervical lymph node enlargement (83.3%) was the commonest presenting symptom. The diagnosis was usually conf...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1988-04-01 00:00:00
abstract:OBJECTIVE:In the diagnostic investigation of impaired auditory processing and perception in children one aspect examined is the auditory sequential memory span. The purpose in this study was to examine the diagnostic usefulness of the subtest Number Recall in the German version of the Kaufman Assessment Battery for Chi...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-007-1621-x
更新日期:2007-12-01 00:00:00
abstract:BACKGROUND:In pre-school children suffering from pure non-inflammatory hyperplasia of the tonsils, tonsillotomy has recently been recommended in preference to tonsillectomy. Absence of inflammatory tonsillitis in the previous medical history is accepted as evidence that tonsillotomy is indicated. In this study, we ther...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-007-1544-6
更新日期:2007-12-01 00:00:00
abstract::At routinely performed autopsies as described by Hamperl in 1956, ENT-specific regions such as the naso- and mesopharynx usually remain untouched. However, in cases with pathological changes in these regions a topographical preparation is necessary. Moreover, there is great interest among ENT-surgeons for studying the...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1994-04-01 00:00:00
abstract:BACKGROUND:The aim of this study was to evaluate the Navibase navigation system for ear, nose, and throat (ENT) surgery. A new methodology for evaluating surgical and human factors is developed. PATIENTS AND METHODS:The evaluation is based on 102 ENT surgical applications, including 89 cases of functional endoscopic s...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-006-1401-z
更新日期:2006-12-01 00:00:00
abstract::The conservative treatment of idiopathic sudden deafness generally shows good results. There are, however, some cases resistant to therapy which may be treated surgically by vestibulotomy. Reports are made on personal experiences as well as those of other authors. Vestibulotomy is recommended for those patients in who...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1975-03-01 00:00:00
abstract:BACKGROUND:In order to evaluate the possible submillimeter application accuracy in computer-aided navigation in the petrous bone, we performed a set of approximately 3,000 measurements on a specially prepared anatomic specimen using the Zeiss STN intraoperative navigation system. This allowed direct measurements of rel...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-003-0964-1
更新日期:2004-08-01 00:00:00
abstract::Concluding from audiometrical practice using hearing aids unilaterally we could find an inactivity of the unused contralateral ear. We have investigated if it is possible to measure this inactivity by common psychoacoustic methods. We tested 92 persons with advanced combined hearing loss. We had to state that the inac...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1989-11-01 00:00:00
abstract::Dementia results not only in the impairment of cognitive-mnestic skills, but also of communication skills. Symptoms include difficulties in finding words and limited expression. The diagnosis of speech and language pathologies in dementia is problematic because there are no standard examination methods. Furthermore, i...
journal_title:HNO
pub_type: 杂志文章,评审
doi:10.1007/s00106-004-1135-8
更新日期:2005-02-01 00:00:00
abstract:BACKGROUND:The prognostic potential of click-evoked early acoustic evoked potentials (EAEP) for vestibular schwannoma (VS) diagnostics is considered insufficient for tumors small than approximately <1.5 cm in diameter. However, up until now, the derivations at higher sound pressure levels have mainly been used for EAEP...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-016-0261-4
更新日期:2017-09-01 00:00:00
abstract::The nasal approach for operations of the maxillary sinus is becoming increasingly popular. The oral approach provides the best access for demonstration of the orbital floor, for ligation of the maxillary artery, for drainage of resistant rhinogenic sinusitis, and for removal of foreign bodies, tooth roots, dislocated ...
journal_title:HNO
pub_type: 杂志文章,评审
doi:
更新日期:1988-12-01 00:00:00
abstract::Ionomeric bone bond cement (Ionocem) is a new alloplastic bone replacement material, which was used by us for functional and aesthetic purposes in surgery of the head and neck. We have used the cement 44 times (in 43 patients) for repair of skull and mid-face trauma, reconstruction of defects after tumor removal and f...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1993-02-01 00:00:00
abstract:BACKGROUND:There are controversial opinions about the incidence of hearing impairment of children and adolescents with Down's syndrome as an additional cause for obstruction in social and communicative live. Next to congenital diseases of the inner ear, functional limitations can often lead to conductive hearing disord...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-004-1205-y
更新日期:2006-03-01 00:00:00
abstract::In 1987 Lopez published the results of a survey of voice rehabilitation after total laryngectomy as carried out by 400 North American ENT surgeons. In order to obtain the same information on the current state of voice rehabilitation in the German Federal Republic we did a similar survey of 103 ENT clinics. Ninety-five...
journal_title:HNO
pub_type: 杂志文章
doi:
更新日期:1990-11-01 00:00:00
abstract:BACKGROUND:The microvascular anastomosed transverse rectus abdominis muscle (TRAM) island flap has been successfully used in plastic surgery for more than 10 years. In reconstructive head and neck surgery, however, it is not yet established. METHOD:We analysed the preparation and anatomical variation in TRAM flaps in ...
journal_title:HNO
pub_type: 杂志文章
doi:10.1007/s00106-005-1286-2
更新日期:2006-01-01 00:00:00