Abstract：
AIMS:To investigate about serum PCT, IL-6 and IL-8 levels and how they are affected by the treatment in diabetic foot patients. METHODS:Fifty patients' blood samples were taken to study ESR and CRP, IL-6, IL-8 and PCT before and at the 14th day of the treatment. RESULTS:The pretreatment results of the 50 patients showed positive correlations between PCT and either ESH (r=0.49, p<0.001), or CRP (r=0.56, p<0.001). Similarly, there was a positive correlation between IL-6 and ESH (r=0.46, p=0.001), just like as it was between IL-6 and CRP (r=0.54, p<0.001). At the 14th day, the levels of ESR (70 ± 30.2 and 58.4 ± 26.2, p=0.02), CRP (63.8 ± 73.1 and 18.1 ± 19.7, p<0.001) and PCT (0.6 ± 2.1 and 0.05 ± 0.02, p=0.007) were significantly decreased while IL-6 was decreased at a close range to statistical significancy at healing patients (97.5 ± 147.2 and 47.1 ± 77.6; p=0.05), but they did not at nonhealing patients. IL-8 levels were not changed anyhow. CONCLUSIONS:PCT was significantly decreased such as ESR and CRP were in the early phase of healing; IL-6 and IL-8 levels were also decreased by the treatment, but not statistically significantly. IL-6 and PCT were affected in correlation with the other inflammatory parameters in the beginning, but IL-8 was not. PCT and IL-6 may be useful like CRP and ESR in the diagnosis and follow up of diabetic foot infection, but IL-8 is not. Further investigation is needed.
journal_name
J Diabetes Complicationsjournal_title
Journal of diabetes and its complicationsauthors
Altay FA,Sencan İ,Şentürk GÇ,Altay M,Güvenman S,Ünverdi S,Açıkgöz ZCdoi
10.1016/j.jdiacomp.2012.03.018subject
Has Abstractpub_date
2012-05-01 00:00:00pages
214-8issue
3eissn
1056-8727issn
1873-460Xpii
S1056-8727(12)00058-Xjournal_volume
26pub_type
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journal_title：Journal of diabetes and its complications
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abstract：BACKGROUND:Altered platelet morphology and function have been reported in patients with diabetes mellitus. They are likely to be associated with the pathological processes and increased risk of vascular disease seen in these patients. We aimed to determine the mean platelet volume (MPV) in diabetics compared to nondiab...
journal_title：Journal of diabetes and its complications
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journal_title：Journal of diabetes and its complications
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journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
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journal_title：Journal of diabetes and its complications
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journal_title：Journal of diabetes and its complications
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journal_title：Journal of diabetes and its complications
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journal_title：Journal of diabetes and its complications
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journal_title：Journal of diabetes and its complications
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更新日期：1997-03-01 00:00:00
abstract：OBJECTIVE:Little is known about serum concentrations of Matrix Metalloproteinase-9 (MMP-9), MMP-2, TIMP-1 and TIMP-2 in diabetic patients with foot ulcers. This study demonstrates their relationship with wound healing. METHODS:Ninety-four patients with diabetic foot ulcers were recruited in the study. Serum MMP-9, MMP...
journal_title：Journal of diabetes and its complications
pub_type： 杂志文章
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更新日期：2013-07-01 00:00:00
abstract：OBJECTIVES:Controversy remains as to the effects of type 2 diabetes on bone metabolism. The aims of this study were to assess the association between type 2 diabetes and bone mineral density (BMD) and to evaluate the possible relationship between chronic diabetic complications and bone density. METHODS:Bone mineral de...
journal_title：Journal of diabetes and its complications
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journal_title：Journal of diabetes and its complications
pub_type： 杂志文章,meta分析
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journal_title：Journal of diabetes and its complications
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pub_type： 杂志文章,评审
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abstract：AIMS:To determine the association between 20-year trajectories in insulin resistance (IR) since young adulthood and appendicular lean mass (ALM) at middle-age in adults without diabetes. METHODS:A prospective cohort study was designed among young and middle-aged US men (n = 925) and women (n = 1193). Fasting serum glu...
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