Abstract:
:Fas is a transmembrane receptor involved in the death program of several cell lines, including T lymphocytes. Deleterious mutations hitting genes involved in the Fas pathway cause the autoimmune lymphoprolipherative syndrome (ALPS). Moreover, defective Fas function is involved in the development of common autoimmune diseases, including autoimmune syndromes hitting the nervous system, such as multiple sclerosis (MS) and chronic inflammatory demyelinating polyneuropathy (CIDP). In this review, we first explore some peculiar aspects of Fas mediated apoptosis in the central versus peripheral nervous system (CNS, PNS); thereafter, we analyze what is currently known on the role of T cell apoptosis in both MS and CIDP, which, in this regard, may be seen as two faces of the same coin. In fact, we show that, in both diseases, defective Fas mediated apoptosis plays a crucial role favoring disease development and its chronic evolution.
journal_name
Autoimmun Revjournal_title
Autoimmunity reviewsauthors
Comi C,Fleetwood T,Dianzani Udoi
10.1016/j.autrev.2011.08.011subject
Has Abstractpub_date
2012-12-01 00:00:00pages
150-6issue
2eissn
1568-9972issn
1873-0183pii
S1568-9972(12)00078-Xjournal_volume
12pub_type
杂志文章,评审abstract::Despite the improvement in the quality of life of patients with SLE due to scientific and technological advances, SLE remains a disease that over the years may produce irreversible damage to patients. Osteoporosis and secondary bone fractures are two of the major causes of irreparable injury in patients with SLE. Vita...
journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2017.09.011
更新日期:2017-11-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 历史文章,杂志文章,评审
doi:10.1016/j.autrev.2012.07.014
更新日期:2012-11-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章
doi:10.1016/j.autrev.2020.102612
更新日期:2020-09-01 00:00:00
abstract::Anti-neutrophil cytoplasmic antibodies (ANCA) are a family of autoantibodies that react with proteins predominantly expressed in cytoplasmic granules of polymorphonuclear neutrophil granulocytes (PMNs). ANCA was initially detected using indirect immunofluorescence, allowing for different patterns such as p-ANCA (perin...
journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2016.07.016
更新日期:2016-10-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2015.03.007
更新日期:2015-08-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2017.05.019
更新日期:2017-08-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2011.01.007
更新日期:2011-06-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2007.02.019
更新日期:2007-12-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2004.07.035
更新日期:2004-11-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2017.05.016
更新日期:2017-08-01 00:00:00
abstract::The "exposome" is a term recently used to describe all environmental factors, both exogenous and endogenous, which we are exposed to in a lifetime. It represents an important tool in the study of autoimmunity, complementing classical immunological research tools and cutting-edge genome wide association studies (GWAS)....
journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2012.12.005
更新日期:2013-05-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2007.03.007
更新日期:2007-11-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2003.08.002
更新日期:2004-03-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2014.12.002
更新日期:2015-04-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2005.08.009
更新日期:2006-02-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2015.03.001
更新日期:2015-07-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章
doi:10.1016/j.autrev.2009.10.001
更新日期:2010-02-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章
doi:10.1016/j.autrev.2008.04.005
更新日期:2008-07-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2009.11.008
更新日期:2010-03-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章
doi:10.1016/j.autrev.2014.08.024
更新日期:2014-10-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2017.07.018
更新日期:2017-10-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2009.02.033
更新日期:2009-09-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/s1568-9972(02)00084-8
更新日期:2002-12-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2009.11.015
更新日期:2010-04-01 00:00:00
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journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2009.03.011
更新日期:2009-12-01 00:00:00
abstract:BACKGROUND:Increased expression of RNA polymerase 1 (POL1) molecular pathway was reported to be associated with increased disease activity in patients with multiple sclerosis (MS). However, the operating molecular mechanisms that characterize the pattern of acute MS relapse activity has not been thoroughly studied. OB...
journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2018.07.006
更新日期:2018-12-01 00:00:00
abstract::The earliest experimental trials of monoclonal antibodies took place in the early 1980s using murine monoclonal antibodies directed at human lymphoma and leukemia cell antigens. Since those early trials, therapeutic advances have produced monoclonal antibodies and fusion proteins that are now used in multiple disease ...
journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2016.07.001
更新日期:2016-09-01 00:00:00
abstract::Since many years immunologists have being tried to answer the tantalizing enigma of immunological tolerance. Complex mechanisms in both thymus (central tolerance) and peripheral lymphoid organs (peripheral tolerance) underly lymphocyte tolerance and its maintenance. The genesis of autoimmunity involves environmental a...
journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2010.08.019
更新日期:2011-01-01 00:00:00
abstract::Viral infections are involved in the pathogenesis of blood autoimmune diseases such as hemolytic anemia and thrombocytopenia. Although antigenic mimicry has been proposed as a major mechanism by which viruses could trigger the development of such diseases, it is not easy to understand how widely different viruses migh...
journal_title:Autoimmunity reviews
pub_type: 杂志文章,评审
doi:10.1016/j.autrev.2004.11.010
更新日期:2005-04-01 00:00:00
abstract::Myasthenia gravis (MG) is an autoimmune disease characterized by muscle weakness, fatigability, and autoantibodies against protein antigens of the muscle endplate. Antibodies against acetylcholine receptor (AChR), and less frequently against muscle-Specific Kinase (MuSK) or lipoprotein related protein 4 (LRP4) occur i...
journal_title:Autoimmunity reviews
pub_type: 杂志文章
doi:10.1016/j.autrev.2014.08.039
更新日期:2014-10-01 00:00:00