Progress in circulating tumor cell capture and analysis: implications for cancer management.

Abstract:

:The hematogenous dissemination of cancer and development of distant metastases is the cause of nearly all cancer deaths. Detection of circulating tumor cells (CTCs) as a surrogate biomarker of metastases has gained increasing interest. There is accumulating evidence on development of novel technologies for CTC detection, their prognostic relevance and their use in therapeutic response monitoring. Many clinical trials in the early and metastatic cancer setting, particularly in breast cancer, are including CTCs in their translational research programs and as secondary end points. We summarize the progress of detection methods in the context of their clinical importance and speculate on the possibilities of wider implementation of CTCs as a diagnostic oncology tool, the likelihood that CTCs will be used as a useful biomarker, especially to monitor therapeutic response, and what may be expected from the future improvements in technologies.

journal_name

Expert Rev Mol Diagn

authors

Balic M,Lin H,Williams A,Datar RH,Cote RJ

doi

10.1586/erm.12.12

subject

Has Abstract

pub_date

2012-04-01 00:00:00

pages

303-12

issue

3

eissn

1473-7159

issn

1744-8352

journal_volume

12

pub_type

杂志文章,评审
  • Genomic and proteomic approaches for Chagas' disease: critical analysis of diagnostic methods.

    abstract::Trypanosoma cruzi is the etiologic agent of Chagas' disease, a chronic inflammatory condition that results in heart and digestive complications. The first draft of the parasite genome is now complete and it is expected that, along with the published genomic and proteomic analyses discussed herein, it will lead to the ...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.5.4.521

    authors: Huete-Pérez JA,Flores-Obando RE,Ghedin E,Caffrey CR

    更新日期:2005-07-01 00:00:00

  • Beyond cardiac troponin: recent advances in the development of alternative biomarkers for cardiovascular disease.

    abstract::Biomarkers complement clinical assessment, electrocardiogram and cardiac imaging in the diagnosis, risk stratification, triage and management of patients with suspected acute cardiovascular diseases. While there is broad consensus that cardiac troponin is the preferred biomarker in clinical practice for the detection ...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.2015.1010519

    authors: Rubini Gimenez M,Twerenbold R,Mueller C

    更新日期:2015-04-01 00:00:00

  • Thin-film technology for direct visual detection of nucleic acid sequences: applications in clinical research.

    abstract::Certain optical conditions permit the unaided eye to detect thickness changes on surfaces on the order of 20 A, which are of similar dimensions to monomolecular interactions between proteins or hybridization of complementary nucleic acid sequences. Such detection exploits specific interference of reflected white light...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.6.1.89

    authors: Jenison RD,Bucala R,Maul D,Ward DC

    更新日期:2006-01-01 00:00:00

  • Nanodiagnostics for tuberculosis detection.

    abstract:INTRODUCTION:Tuberculosis (TB) is a leading killer worldwide. End TB strategy aims at ending the TB epidemic by 2030. Early, accurate, and affordable diagnosis represents a cornerstone to achieve this goal. Innovative strategies for TB diagnostics have been introduced. However, the ideal assay is yet unavailable and co...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1080/14737159.2017.1308825

    authors: El-Samadony H,Althani A,Tageldin MA,Azzazy HME

    更新日期:2017-05-01 00:00:00

  • Diagnostic potential of peritoneal fluid biomarkers of endometriosis.

    abstract::Endometriosis is defined as the presence of endometrial glands and stroma outside the uterus, in different parts of the peritoneal cavity. It affects up to 10% of reproductive-age women and up to 50% of women with infertility. Surgical diagnosis of endometriosis is still the gold standard, with no diagnostic biomarker...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.2015.1015994

    authors: Rižner TL

    更新日期:2015-04-01 00:00:00

  • Molecular diagnostics: a healthcare perspective.

    abstract::Recent progress in the development of molecular diagnostics in medicine has been rapid and the hope has been expressed by some people that it will soon be possible to have a detailed 'genetic readout' to assist in the diagnosis of treatment of a variety of diseases. However, such an outcome may be neither achievable n...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.3.1.13

    authors: Hall AG,Coulthard SA,Irving JA

    更新日期:2003-01-01 00:00:00

  • An updated view on the origin and use of angiogenic biomarkers for preeclampsia.

    abstract::Introduction: The last decade has seen massive efforts towards the identification and the potential use of predictive biomarkers for the pregnancy pathology preeclampsia. The angiogenic factors sFlt-1 and placental growth factor (PGF) have been in focus and have been massively supported. Areas covered: This review des...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1080/14737159.2018.1546579

    authors: Huppertz B

    更新日期:2018-12-01 00:00:00

  • Molecular profiling of tissue samples using laser capture microdissection.

    abstract::The management of cancer and other genetically based diseases is far from optimal in even our most advanced medical centers. There is still uncertainty regarding how diseases will progress in certain patients, toxicity that must be tolerated with imprecise treatment regimens and significant potential for treatment fai...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.1.1.53

    authors: Best CJ,Emmert-Buck MR

    更新日期:2001-05-01 00:00:00

  • Oligonucleotide microarrays in constitutional genetic diagnosis.

    abstract::Oligonucleotide microarrays such as comparative genomic hybridization arrays and SNP microarrays enable the identification of genomic imbalances - also termed copy-number variants - with increasing resolution. This article will focus on the most significant applications of high-throughput oligonucleotide microarrays, ...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/erm.11.32

    authors: Keren B,Le Caignec C

    更新日期:2011-06-01 00:00:00

  • Molecular analysis of the destruction of articular joint tissues by Raman spectroscopy.

    abstract:INTRODUCTION:Osteoarthritis (OA) is a highly heterogenous disease influenced by different molecular, anatomic, and physiologic imbalances. Some of the bottlenecks for enhanced diagnosis and therapeutic assessment are the lack of validated biomarkers and early diagnosis tools. In this narrative review, we analyze the po...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章

    doi:10.1080/14737159.2020.1782747

    authors: Casal-Beiroa P,González P,Blanco FJ,Magalhães J

    更新日期:2020-08-01 00:00:00

  • Recent progress in protein profiling of clinical tissues for next-generation molecular diagnostics.

    abstract::Differences in protein levels and the activation of signaling pathways have been extensively studied in tumor tissues, but the implementation of protein profiling methods in routine hospital workflows lags far behind that of nucleic acid-based approaches. In this review, major technologies that are currently used for ...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.2015.1070098

    authors: Boellner S,Becker KF

    更新日期:2015-01-01 00:00:00

  • Application of mass spectrometry to molecular diagnostics of viral infections.

    abstract::Mass spectrometry (MS) has found numerous applications in life sciences. It has high accuracy, sensitivity and wide dynamic range in addition to medium- to high-throughput capabilities. These features make MS a superior platform for analysis of various biomolecules including proteins, lipids, nucleic acids and carbohy...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/erm.13.24

    authors: Ganova-Raeva LM,Khudyakov YE

    更新日期:2013-05-01 00:00:00

  • Portable devices and mobile instruments for infectious diseases point-of-care testing.

    abstract:INTRODUCTION:Rapidity, simplicity, and portability are highly desirable characteristics of tests and devices designed for performing diagnostics at the point of care (POC), either near patients managed in healthcare facilities or to offer bioanalytical alternatives in external settings. By reducing the turnaround time ...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1080/14737159.2017.1310619

    authors: Bissonnette L,Bergeron MG

    更新日期:2017-05-01 00:00:00

  • PNA FISH: present and future impact on patient management.

    abstract::Inappropriate and inaccurate antimicrobial therapy can lead to adverse patient outcomes and also the development of antimicrobial resistance. Peptide nucleic acid (PNA) fluorescence in situ hybridization (FISH) gives rapid reporting with highly sensitive and specific results to clinicians within 3 h after blood cultur...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.7.3.231

    authors: Forrest GN

    更新日期:2007-05-01 00:00:00

  • Emerging techniques employed in aptamer-based diagnostic tests.

    abstract::Since aptamers were reported in 1990, research into the applications of aptamers, particularly diagnostic applications, has been growing. Aptamers can act as recognition elements instead of antibodies. In this regard, aptamers have unique characteristics because they are composed of nucleic acids. Intra- and intermole...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.2014.868307

    authors: Yoshida W,Abe K,Ikebukuro K

    更新日期:2014-03-01 00:00:00

  • Prognostic and predictive biomarkers in prostate cancer.

    abstract::Prostate cancer (PCa) is one of the leading causes of cancer death among males, especially in more developed countries. Diagnosis is often achieved at an early stage of the disease with prostate biopsy, following a screening test showing elevated serum levels of prostate-specific antigen or a positive digital rectal e...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.2015.1110022

    authors: Kontos CK,Adamopoulos PG,Scorilas A

    更新日期:2015-01-01 00:00:00

  • Circulating peripheral blood mononuclear cells exhibit altered miRNA expression patterns in pancreatic cancer.

    abstract::Evaluation of: Wang WS, Liu LX, Li GP et al. Combined serum CA19-9 and miR-27a-3p in peripheral blood mononuclear cells to diagnose pancreatic cancer. Cancer Prev. Res. (Phila.) 6(4), 331-338 (2013). Patients with pancreatic ductal adenocarcinoma (PDAC) have a bleak outlook, primarily because tumors are detected late ...

    journal_title:Expert review of molecular diagnostics

    pub_type: 评论,杂志文章

    doi:10.1586/erm.13.31

    authors: Frampton AE,Fletcher CE,Gall TM,Castellano L,Bevan CL,Stebbing J,Krell J

    更新日期:2013-06-01 00:00:00

  • Rapid tests for detection of viral markers in blood transfusion.

    abstract::Since the early 1990s, rapid tests have been available for detection of HIV infection. They were intended for field diagnosis, emergency and home testing. In addition, rapid tests for anti-HIV, hepatitis B surface antigen and antihepatitis C virus have been used for blood screening in many resource-poor areas to save ...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章

    doi:10.1586/14737159.5.1.31

    authors: Allain JP,Lee H

    更新日期:2005-01-01 00:00:00

  • Evaluating the use of PCR for diagnosing invasive aspergillosis.

    abstract:INTRODUCTION:Aspergillus species, primarily Aspergillus fumigatus, are still the most emerging fungal pathogens. Within recent years, novel molecular methods have been developed to improve the diagnosis of life-threatening invasive aspergillosis in high risk patients. Especially patients with malignant hematological di...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1080/14737159.2017.1325735

    authors: Buchheidt D,Reinwald M,Hofmann WK,Boch T,Spiess B

    更新日期:2017-06-01 00:00:00

  • Personalized medicine and pharmacogenetic biomarkers: progress in molecular oncology testing.

    abstract::In the field of oncology, clinical molecular diagnostics and biomarker discoveries are constantly advancing as the intricate molecular mechanisms that transform a normal cell into an aberrant state in concert with the dysregulation of alternative complementary pathways are increasingly understood. Progress in biomarke...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/erm.12.59

    authors: Ong FS,Das K,Wang J,Vakil H,Kuo JZ,Blackwell WL,Lim SW,Goodarzi MO,Bernstein KE,Rotter JI,Grody WW

    更新日期:2012-07-01 00:00:00

  • The clinical implementation of copy number detection in the age of next-generation sequencing.

    abstract:INTRODUCTION:The role of copy number variants (CNVs) in disease is now well established. In parallel NGS technologies, such as long-read technologies, there is continual development and data analysis methods continue to be refined. Clinical exome sequencing data is now a reality for many diagnostic laboratories in both...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1080/14737159.2018.1523723

    authors: Hehir-Kwa JY,Tops BBJ,Kemmeren P

    更新日期:2018-10-01 00:00:00

  • Near instrument-free, simple molecular device for rapid detection of herpes simplex viruses.

    abstract::The first near instrument-free, inexpensive and simple molecular diagnostic device (IsoAmp HSV, BioHelix Corp., MA, USA) recently received US FDA clearance for use in the detection of herpes simplex viruses (HSV) in genital and oral lesion specimens. The IsoAmp HSV assay uses isothermal helicase-dependent amplificatio...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/erm.12.34

    authors: Lemieux B,Li Y,Kong H,Tang YW

    更新日期:2012-06-01 00:00:00

  • Traceability of genetically modified organisms.

    abstract::EU regulations stipulate the labeling of food products containing genetically modified organisms (GMOs) unless the GMO content is due to adventitious and unintended 'contamination' and not exceeding the 1% level at ingredient basis. In addition, member states have to ensure full traceability at all stages of the placi...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.2.1.69

    authors: Aarts HJ,van Rie JP,Kok EJ

    更新日期:2002-01-01 00:00:00

  • Detection of BRCA1/2 large genomic rearrangements in breast and ovarian cancer patients: an overview of the current methods.

    abstract::Introduction: Currently, genetic testing of BRCA1/2 genes includes screening for single-nucleotide variants, small insertions/deletions, and copy number variations (CNVs). In fact, many studies document the involvement of BRCA1/2 gene rearrangements in genetic predisposition to breast and ovarian cancer. Large genomic...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1080/14737159.2019.1657011

    authors: Concolino P,Capoluongo E

    更新日期:2019-09-01 00:00:00

  • The cellular prion protein and its derived fragments in human prion diseases and their role as potential biomarkers.

    abstract::Introduction: Human prion diseases are a heterogeneous group of incurable and debilitating conditions characterized by a progressive degeneration of the central nervous system. The conformational changes of the cellular prion protein and its formation into an abnormal isoform, spongiform degeneration, neuronal loss, a...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1080/14737159.2019.1667231

    authors: Thüne K,Schmitz M,Villar-Piqué A,Altmeppen HC,Schlomm M,Zafar S,Glatzel M,Llorens F,Zerr I

    更新日期:2019-11-01 00:00:00

  • Measurement of blood activation markers applied to the early diagnosis of cardiovascular alterations.

    abstract::Introduction: This review concerns biomarkers of blood activation and their measurement in plasma, as described in the literature up to 2019, and from our personal experience. How their measurement can be informative and useful, for research studies or for diagnostic applications, is presented and discussed.Areas cove...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章

    doi:10.1080/14737159.2020.1704258

    authors: Amiral J

    更新日期:2020-01-01 00:00:00

  • The introduction of syphilis point of care tests in resource limited settings.

    abstract:INTRODUCTION:Syphilis remains an important and preventable cause of stillbirth and neonatal mortality. About 1 million women with active syphilis become pregnant each year. Without treatment, 25% of them will deliver a stillborn baby and 33% a low birth weight baby with an increased chance of dying in the first month o...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1080/14737159.2017.1303379

    authors: Marks M,Mabey DC

    更新日期:2017-04-01 00:00:00

  • A profile of the cobas® CT/NG assay on the cobas® 6800/8800 system for detection of Chlamydia trachomatis and Neisseria gonorrhoeae.

    abstract::Introduction: Chlamydia trachomatis and Neisseria gonorrhoeae infection rates continue to rise worldwide. Increasing screening of the largely asymptomatic infections is critical for timely and effective disease control. Laboratory solutions that can handle increasing volumes and generate highly accurate test results a...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章

    doi:10.1080/14737159.2020.1724093

    authors: Van Der Pol B

    更新日期:2020-04-01 00:00:00

  • Hereditary sensorineural hearing loss: advances in molecular genetics and mutation analysis.

    abstract::Hearing loss has a genetic etiology in the majority of cases and is very common. The universal newborn hearing screening program, together with remarkable recent progress in the characterization of genes associated with the function of hearing, have resulted in increased demand and exciting possibilities of detecting ...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/14737159.6.3.375

    authors: Schrijver I,Gardner P

    更新日期:2006-05-01 00:00:00

  • Primary and secondary prevention of cervical cancer.

    abstract::The burden of cervical cancer is very high in low-resource countries, while it is lower in several high-income countries. Secondary prevention based on cervical screening has been very successful in countries where the resources exist to ensure high-quality and good coverage of the population at risk. In many develope...

    journal_title:Expert review of molecular diagnostics

    pub_type: 杂志文章,评审

    doi:10.1586/erm.09.64

    authors: Grce M

    更新日期:2009-11-01 00:00:00