Abstract：
:NF-κB proteins were identified in the search for mechanisms that regulate B-lymphocyte-specific transcription of immunoglobulin κ light chain genes. Twenty-five years later, though the function of the κB site in the enhancer remains enigmatic, NF-κB proteins have been shown to have important roles in B-cell development, maintenance, and function. In this review, we summarize the functions of NF-κB in B cells. An overview of B-cell biology that identifies stages in the life of B lymphocytes for the general reader is followed by three sections that examine the role of NF-κB family of proteins in B-cell development, mature B-cell survival and B-cell function. We endeavor throughout to suggest mechanisms and implications of the wide-ranging observations that have been made and conclude by highlighting the need to understand NF-κB-mediated gene expression in more depth.
journal_name
Immunol Revjournal_title
Immunological reviewsauthors
Kaileh M,Sen Rdoi
10.1111/j.1600-065X.2012.01106.xsubject
Has Abstractpub_date
2012-03-01 00:00:00pages
254-71issue
1eissn
0105-2896issn
1600-065Xjournal_volume
246pub_type
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