Mechanisms of protein kinase Sch9 regulating Bcy1 in Saccharomyces cerevisiae.

Abstract:

:In this study, we investigated the mechanisms of Sch9 regulating the localization and phosphorylation of Bcy1. Our research indicated that Sch9 regulated localization of Bcy1 via Zds1 for the following reasons: (1) deletions of SCH9 or ZDS1 both caused nuclear localization of Bcy1; (2) Sch9 and Zds1 interacted physically; (3) overexpression of ZDS1 led to a significantly increased cytoplasmic localization of Bcy1 in sch9Δ cells, whereas overexpression of SCH9 had no visible effect on cytoplasmic localization of Bcy1 in zds1Δ cells. Our study also suggested that Sch9 regulated phosphorylation of Bcy1 via Yak1.

journal_name

FEMS Microbiol Lett

authors

Zhang A,Gao W

doi

10.1111/j.1574-6968.2012.02552.x

subject

Has Abstract

pub_date

2012-06-01 00:00:00

pages

10-6

issue

1

eissn

0378-1097

issn

1574-6968

journal_volume

331

pub_type

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