Chemical reaction of soybean flavonoids with DNA: a computational study using the implicit solvent model.

Abstract:

:Genistein, daidzein, glycitein and quercetin are flavonoids present in soybean and other vegetables in high amounts. These flavonoids can be metabolically converted to more active forms, which may react with guanine in the DNA to form complexes and can lead to DNA depurination. We assumed two ultimate carcinogen forms of each of these flavonoids, diol epoxide form and diketone form. Density functional theory (DFT) and Hartree-Fock (HF) methods were used to study the reaction thermodynamics between active forms of flavonoids and DNA guanine. Solvent reaction field method of Tomasi and co-workers and the Langevin dipoles method of Florian and Warshel were used to calculate the hydration free energies. Activation free energy for each reaction was estimated using the linear free energy relation. Our calculations show that diol epoxide forms of flavonoids are more reactive than the corresponding diketone forms and are hence more likely flavonoid ultimate carcinogens. Genistein, daidzein and glycitein show comparable reactivity while quercetin is less reactive toward DNA.

journal_name

Int J Mol Sci

authors

Abdallah HH,Mavri J,Repič M,Lee VS,Wahab HA

doi

10.3390/ijms13021269

subject

Has Abstract

pub_date

2012-01-01 00:00:00

pages

1269-83

issue

2

issn

1422-0067

pii

ijms-13-01269

journal_volume

13

pub_type

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