Abstract：
BACKGROUND AND OBJECTIVE:The vanilloid receptor TRPV1 is a molecular integrator of painful stimuli. Several recent studies suggest that TRPV1 may play a role in development and maintenance of chronic pain. In an attempt to determine if genotypic variations in TRPV1 gene could be involved in the susceptibility to suffer neuropathic pain we have studied genetic variants of human TRPV1 gene. PATIENTS AND METHODS:We have studied the distribution of Met315Ile and Ile585Val TRPV1 polymorphisms in a total of 440 Caucasian subjects: 232 patients with neuropathic pain and 208 healthy subjects matched by age and sex. The polymorphisms were analyzed with polymerase chain reaction (PCR) using TaqMan probes specific for each allele. RESULTS:Our results show that the distribution of Met315Ile and Ile585Val genotypes and alleles is similar in patients with neuropathic pain and in healthy subjects. However, the Met315Met genotype is more frequent in females diagnosed as suffering neuropathic pain. No differences were observed when we segregate the patients according to visual analogue scale values. CONCLUSIONS:The observation of differences in the distribution of Met315Ile TRPV1 genotypes only in females diagnosed of neuropathic pain suggests that this polymorphism, together with other physiological factors such as sex, may influence individual susceptibility to neuropathic pain.
journal_name
Med Clin (Barc)journal_title
Medicina clinicaauthors
Armero P,Muriel C,López M,Santos J,González-Sarmiento Rdoi
10.1016/j.medcli.2011.10.028subject
Has Abstractpub_date
2012-06-02 00:00:00pages
1-4issue
1eissn
0025-7753issn
1578-8989pii
S0025-7753(12)00050-4journal_volume
139pub_type
杂志文章相关文献
MEDICINA CLINICA文献大全abstract：BACKGROUND AND OBJECTIVE:Twin and family studies support large genetic influences on variability in body mass index (BMI), with heritability estimates ranging from 47% to over 90%. Our objective was to study the relative contributions of genetics and environment to BMI, evaluating sex differences, in an adolescent twin...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2014.05.039
更新日期：2015-08-21 00:00:00
abstract：:Meningitis and other infectious diseases of the central nervous system are predisposing causes of the inadequate secretion syndrome of the antidiuretic hormone (ISADH). The association between the acquired immunodeficiency syndrome (AIDS) and ISADH is recognized but little studied. In AIDS patients hyponatremia is a f...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1993-03-20 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We aimed to know the prevalence of classical cardiovascular risk factors, hyperinsulinism, insulin resistance and metabolic syndrome (MS) in a population with coronary heart disease (CHD) as compared with a population without personal or familial history of cardiovascular risk factors. SUBJECT...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(03)73907-4
更新日期：2003-07-12 00:00:00
abstract：:The REACH registry allows the degree of control of risk factors associated with atherothrombosis to be evaluated. Although 90% were taking at least one antihypertensive agent, hypertension was controlled in only 42.9% of the patients with vascular disease. This inadequate control may have multiple causes but the main ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/S0025-7753(09)71754-3
更新日期：2009-09-01 00:00:00
abstract：INTRODUCTION AND OBJECTIVE:To achieve control of rheumatoid arthritis (RA) it is necessary to be able to evaluate its activity. The American College of Rheumatology (ACR) recommends for this purpose indexes of activity that can be performed by the patient (PAS-II and RAPID-3) and IA including medical evaluation with la...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2017.02.025
更新日期：2017-10-11 00:00:00
abstract：:We report 3 patients with chronic myeloproliferative syndromes and active tuberculous infection. The first patient had chronic myelocytic leukemia. In this patient, primary tuberculosis was localized in the lung. In spite of tuberculostatic treatment, he developed laterocervical lymphadenopathy and a tuberculous absce...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1990-04-21 00:00:00
abstract：:Familial hypophosphoremic rickets, although exceptional, is a frequent form of presentation in communities where nutritional rachitism has been eradicated. Hypophosphoremia is the biochemical defect which led to an insuffieient osseous mineralization. The real pathogenic mechanism of the disease is still unknown. Two ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1980-04-10 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Since World Health Organization (WHO) recommends brief interventions for smoking cessation to be included systematically in daily practise as a part of clinical work, the main aim of this study is to know if this intervention is done by health professionals working in hospital wards in a genera...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13106128
更新日期：2007-05-19 00:00:00
abstract：:The clinical records of 304 patients with acute respiratory insufficiency were studied in retrospect. All of them had been treated in an Intensive Care Unit during its first year and a half of operation. One hundred and thirty-one patients suffered from chronic obstructive lung disease and acute episodes of chronic re...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1979-01-25 00:00:00
abstract：BACKGROUND AND OBJECTIVES:Endoscopy is the gold standard to assess disease severity in inflammatory bowel disease, although it is an invasive procedure. Clinical activity and biological markers have been routinely used to determine disease activity in a non-invasive manner. The aim of this study was to determine concor...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2013.09.047
更新日期：2015-01-06 00:00:00
abstract：:Giant cell myocarditis is a rare disease of unknown etiology, which develops as a myocardial isolated affection or associated to different diseases. Its characteristics are such as necrosis, inflammation and giant cell presence in the myocardium. We present the case of a woman who suffered of giant cell myocarditis, t...
journal_title：Medicina clinica
pub_type： 杂志文章,评审
doi：
更新日期：1993-10-16 00:00:00
abstract：:The electrocardiogram as a diagnostic aid in acute myocardial infarction of the right ventricle (AMI-RV) was studied prospectively in a group of 66 patients in our coronary unit. Diagnosis was AMI in all cases, divided into 29 (44%) with posterior-descending and 35 (53%) with anterior location. Electrocardiography was...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-09-25 00:00:00
abstract：BACKGROUND AND OBJECTIVE:After the good results obtained by the Société Française d'Oncologie Pédiatrique (SFOP) regarding the pediatric B-type non-Hodgkin's (Burkitt and large B-cell) lymphoma and L3 leukemia, the Sociedad Española de Hematología y Oncología Pediátricas (SHOP) decided to use the same treatment protoco...
journal_title：Medicina clinica
pub_type： 临床试验,杂志文章,多中心研究
doi：10.1157/13102049
更新日期：2007-05-05 00:00:00
abstract：BACKGROUND:Fetal microchimerism (FM) has been implicated in the pathogenesis of primary biliary cirrhosis (PBC). The aim of the study was to investigate the presence of FM in PBC patients. PATIENTS AND METHOD:FM was studied in 28 women, 14 with PBC and 14 healthy controls.DNA was extracted from peripheral blood cells,...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(02)73575-6
更新日期：2002-12-07 00:00:00
abstract：BACKGROUND:Recent studies have suggested that women with ischemic heart disease receive lesser therapeutic care than males. The aim of this study was to verify the hypothesis that sex is an independent predictive factor in therapeutic care upon admission in patients with acute myocardial infarction. METHODS:Secondary ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1994-03-19 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The plasma protein leakage produced in the bronchial mucose of patients with acute asthma might be associated to the quickness of the onset exacerbation. The aim of this study was to study this association. PATIENTS AND METHOD:22 patients with acute asthma were recruited, and the magnitude of ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13093055
更新日期：2006-09-30 00:00:00
abstract：BACKGROUND:To assess how patients with diabetes experience their condition. PATIENTS AND METHOD:Pilot study conducted in 10 selected patients with type 1 diabetes. A structured interview guide was prepared including physical, social and emotional areas. The information provided was analyzed qualitatively, key statemen...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：BACKGROUND AND OBJECTIVE:Our objective was to assess the activity of thiopurine methyltransferase (TPMT) in a very large number of Spanish patients with inflammatory bowel disease (IBD), to evaluate the influence of several variables (including azathioprine or 6-mercaptopurine) on that activity, and to know the proport...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13078420
更新日期：2005-09-10 00:00:00
abstract：BACKGROUND:The values of the squamous cell carcinoma (SCC) antigen in benign diseases were studied with the aim of determining false positive values in the study of epidermoid carcinomas. METHODS:Serum determinations of the SCC antigen were performed by radioimmunoanalysis with the Abbott SCC-RIA kit. The control grou...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1996-02-17 00:00:00
abstract：BACKGROUND:The differences in clinical presentation, morphology, phenotype and genetic changes between lymphomas originating in the gastrointestinal tract and the lymph nodes justified the proposal of a system of specific classification for lymphomas originating in lymphoid tissue associated to mucosa (MALT). Neverthel...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-10-24 00:00:00
abstract：:Accumulation of pus in the perinephritic cavity often gives rise to doubtful clinical manifestations, which hinder and delay prompt diagnosis of this severe process. The clinical, biological, radiological and therapeutic characteristics of 50 cases are reviewed; all were confirmed by either surgery or necropsy. The mo...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-07-15 00:00:00
abstract：BACKGROUND:To study the evolution of the diet and the nutritional intake between 1983 and 1999, by age and sex. SUBJECTS AND METHODS:We performed a series of analysis of the food intake on a representative sample of the population of Reus (aged 10-69 years). Dietary intake was estimated using the 24-hours recall metho...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/s0025-7753(00)71448-5
更新日期：2000-06-03 00:00:00
abstract：BACKGROUND:To identify and to compare the recommendations of the currently existing clinical protocols for arterial hypertension (HT) screening, diagnosis and baseline study in the Murcia Region, Spain, in order to assess their validity and reliability. MATERIAL AND METHODS:Structured comparative description of guidel...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：2000-01-01 00:00:00
abstract：:The authors study the usefulness of the measurement of the negative area of P in V1 (Morris' index) in patients with acute myocardial infarction. The study was carried out prospectively in 70 patients, 31 of them having a Swan-Ganz catheter inserted permitting simultaneous hemodynamic and electrocardiographic measurem...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1981-03-10 00:00:00
abstract：BACKGROUND:With the aim of studying the characteristics of the use of digoxin in a population which attended a hospital emergency department for heart failure or auricular fibrillation a 3 month observational study was carried out in the emergency department of the Ciudad Sanitaria de la Vall d'Hebron. METHODS:One hun...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1993-01-23 00:00:00
abstract：BACKGROUND AND OBJECTIVE:The standard treatment of the obstructive sleep apnea syndrome (OSAS) is the nCPAP. There is evidence that its use improves the quality of life of patients. The objective of the study is to measure the effect of nCPAP on the quality of life of patients in a Spanish cohort. PATIENTS AND METHOD:...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1157/13080827
更新日期：2005-11-05 00:00:00
abstract：:Hemolytic disease by cold-reacting antibodies is a rare form of hemolytic anemia. In most cases a subjacent cause is found. This disease is generally related with reactive lymphoproliferative processes (infections by the Epstein-Barr virus and cytomegalovirus) or uncontrolled lymphoproliferative disorders (lymphomas, ...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1992-04-04 00:00:00
abstract：:We have evaluated the close contacts of 191 patients diagnosed of tuberculosis in our center between 1984 and 1987. The overall number of evaluated contacts was 666, and the mean number of contacts for each index case was 3.7. In 55% of the evaluated population PPD reaction was positive, and their mean age was 33.3 ye...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1989-04-22 00:00:00
abstract：BACKGROUND AND OBJECTIVE:We aimed to assess the population-based incidence and survival of primary Merkel cell carcinoma. MATERIAL AND METHOD:From January 1995 to December 2005, 19 patients diagnosed with primary Merkel cell carcinoma were recruited in the population-based Cancer Registry of Girona. RESULTS:The age-a...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：10.1016/j.medcli.2008.10.056
更新日期：2009-05-16 00:00:00
abstract：BACKGROUND:The aim of the present study was to validate the SpaceLabs 90207 apparatus used in non-invasive outpatient monitoring of blood pressure. METHODS:The measurements of blood pressure (BP) and cardiac frequency (CF) obtained with the SpaceLabs monitor were compared with those obtained with a mercury sphygmomano...
journal_title：Medicina clinica
pub_type： 杂志文章
doi：
更新日期：1994-09-24 00:00:00
