Cedrol Enhances Extracellular Matrix Production in Dermal Fibroblasts in a MAPK-Dependent Manner.

Abstract:

BACKGROUND:The extracellular matrix (ECM) produced by dermal fibroblasts supports skin structure, and degradation and/or reduced production of ECM are the main causes of wrinkle formation. OBJECTIVE:The aim of this study was to identify the active ingredient that enhances ECM production in dermal fibroblasts. METHODS:Polarity-based fractionation was used to isolate the active ingredient from natural extracts, and the effects of cedrol (isolated from Pterocarpus indicusirginia) on ECM production in cultured human dermal fibroblasts was investigated by reverse transcription-polymerase chain reaction, enzyme linked immunosorbent assay, and Western blot analysis. RESULTS:Cedrol accelerated fibroblast growth in a dose-dependent manner and increased the production of type 1 collagen and elastin. Phosphorylation of p42/44 extracellular signal-regulated kinase, p38 mitogen-activated protein kinase, and Akt was markedly increased by cedrol, indicating that enhanced ECM production is linked to activation of intracellular signaling cascades. CONCLUSION:These results indicate that cedrol stimulates ECM production, with possible applications to the maintenance of skin texture.

journal_name

Ann Dermatol

journal_title

Annals of dermatology

authors

Jin MH,Park SG,Hwang YL,Lee MH,Jeong NJ,Roh SS,Lee Y,Kim CD,Lee JH

doi

10.5021/ad.2012.24.1.16

subject

Has Abstract

pub_date

2012-02-01 00:00:00

pages

16-21

issue

1

eissn

1013-9087

issn

2005-3894

journal_volume

24

pub_type

杂志文章
  • Therapeutic Effect of Superficial Cryotherapy on Alopecia Areata: A Prospective, Split-scalp Study in Patients with Multiple Alopecia Patches.

    abstract:Background:Alopecia areata (AA) affects anagen hair follicles resulting in non-scarring hair loss. Since its introduction, superficial cryotherapy has been used as one of the meaningful treatment modalities for AA. Objective:The purpose of this study is to clarify the therapeutic efficacy and safety of superficial cry...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2017.29.6.722

    authors: Jun M,Lee WS

    更新日期:2017-12-01 00:00:00

  • Acral Lentiginous Melanoma, Indolent Subtype Diagnosed by En Bloc Excision: A Case Report.

    abstract::Nail unit melanoma is a type of acral lentiginous melanoma and requires histopathologic examination for a confirmed diagnosis. However, inadequate biopsy techniques make definitive diagnosis difficult. A 61-year-old man presented with progressive nail pigmentation for 15 years, which was clinically highly suspicious f...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2017.29.3.327

    authors: Ohn J,Bae JM,Lim JS,Park JS,Yoon HS,Cho S,Park HS

    更新日期:2017-06-01 00:00:00

  • Case of epidermolysis bullosa with pyloric atresia.

    abstract::Epidermolysis bullosa (EB) is a rare hereditary disorder characterized by formation of blisters following minor trauma. It has been traditionally categorized by the level of basement membrane zone separation into EB simplex (EBS), junctional EB (JEB), and dystrophic EB (DEB). Recently, hemidesmosomal EB has been propo...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S1.S41

    authors: Kim JH,Park HY,Lee HJ,Eom M,Choi EH

    更新日期:2011-09-01 00:00:00

  • Lack of association of plasma histamine with diamine oxidase in chronic idiopathic urticaria.

    abstract:BACKGROUND:Chronic idiopathic urticaria (CIU) is considered a complex and multifactorial disease. Excessive histamine intake may induce an attack of urticaria. The main enzyme for histamine metabolism is diamine oxidase (DAO). OBJECTIVE:Plasma histamine concentrations and DAO activities were evaluated to determine whe...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2013.25.2.189

    authors: Cho HJ,Cho SI,Kim HO,Park CW,Lee CH

    更新日期:2013-05-01 00:00:00

  • A Case of Extensive Pityriasis Alba.

    abstract::Pityriasis alba (PA) is a common benign disease, characterized by hypopigmented macules or patches on the face, usually seen in children. However, two uncommon variants exist, a pigmenting type and an extensive type. Extensive PA is rare. The lesions tend to be less scaly, more persistent, more generalized, more symme...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2008.20.3.146

    authors: Lee D,Kang JH,Kim SH,Seo JK,Sung HS,Hwang SW

    更新日期:2008-09-01 00:00:00

  • Erratum: ERRATUM.

    abstract::[This corrects the article on p. 217 in vol. 21.]. ...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2009.21.3.335

    authors:

    更新日期:2009-08-01 00:00:00

  • The Investigation on the Distribution of Malassezia Yeasts on the Normal Korean Skin by 26S rDNA PCR-RFLP.

    abstract:BACKGROUND:Malassezia yeasts are normal flora of the skin that are discovered in 75~98% of health subjects, but since its association with various skin disorders have been known, many studies have been conducted in the distribution of the yeasts. OBJECTIVE:To isolate, identify, and classify Malassezia yeasts from the ...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2009.21.1.18

    authors: Jang SJ,Lim SH,Ko JH,Oh BH,Kim SM,Song YC,Yim SM,Lee YW,Choe YB,Ahn KJ

    更新日期:2009-02-01 00:00:00

  • A case of lymphomatoid keratosis.

    abstract::Lymphomatoid keratosis (LK) is considered to be a rare variant of cutaneous lymphoid hyperplasia, with epidermotropism. We herein report a case of LK which developed on the abdomen of an elderly Korean woman. A 60-year-old woman presented with a 10-year history of a pruritic, solitary, brown to black plaque on the abd...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2010.22.2.219

    authors: Choi MJ,Kim HS,Kim HO,Song KY,Park YM

    更新日期:2010-05-01 00:00:00

  • Identification of dermatophytes using multiplex polymerase chain reaction.

    abstract:BACKGROUND:Multiplex polymerase chain reaction (PCR) allows more than two target DNA molecules to be amplified with more than two primers. This method is also useful for detecting various other organisms simultaneously within a single test tube, and the scope of its use has been expanding widely in the field of clinica...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2011.23.3.304

    authors: Kim JY,Choe YB,Ahn KJ,Lee YW

    更新日期:2011-08-01 00:00:00

  • Impact of Different Spa Waters on Inflammation Parameters in Human Keratinocyte HaCaT Cells.

    abstract:BACKGROUND:The treatment of different skin conditions with spa waters is a long tradition dating back to at least late Hellenism. Interestingly, independent scientific examinations studying the effect of spa waters are scarce. OBJECTIVE:In the present in vitro study, we compared the effect of culture media supplemente...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2015.27.6.709

    authors: Zöller N,Valesky E,Hofmann M,Bereiter-Hahn J,Bernd A,Kaufmann R,Meissner M,Kippenberger S

    更新日期:2015-12-01 00:00:00

  • Erratum: Disseminated Superficial Actinic Porokeratosis in a Patient with Psoriasis, after Long-Term Narrowband Ultraviolet B Phototherapy.

    abstract::[This corrects the article on p. 211 in vol. 30, PMID: 29606819.]. ...

    journal_title:Annals of dermatology

    pub_type: 已发布勘误

    doi:10.5021/ad.2018.30.4.511

    authors: Sim CY,Shin JY,Lee SY,Park YL

    更新日期:2018-08-01 00:00:00

  • Fexofenadine-induced urticaria.

    abstract::Fexofenadine (Allegra® 180) is a second-generation antihistamine. It is widely used as anti-allergic drug, which suppresses various allergic reactions mediated by histamines. A few cases of H1-antihistamine-induced urticaria have been reported. Herein, we report a rare case of fexofenadine-induced urticaria which was ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S3.S329

    authors: Lee SW,Byun JY,Choi YW,Myung KB,Choi HY

    更新日期:2011-12-01 00:00:00

  • Efficacy of microneedling plus human stem cell conditioned medium for skin rejuvenation: a randomized, controlled, blinded split-face study.

    abstract:BACKGROUND:The use of growth factors in skin rejuvenation is emerging as a novel anti-aging treatment. While the role of growth factors in wound healing is well established, their use in skin rejuvenation has only recently been to be studied and no controlled trials have been performed. OBJECTIVE:We evaluated the anti...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2014.26.5.584

    authors: Lee HJ,Lee EG,Kang S,Sung JH,Chung HM,Kim DH

    更新日期:2014-10-01 00:00:00

  • A Case of p-ANCA-Positive Propylthiouracil-Induced Pyoderma Gangrenosum.

    abstract::Propylthiouracil is a common medication used in patients with hyperthyroidism; it can cause perinuclear antineutrophil cytoplasmic antibodies (p-ANCA) in some patients with Graves' disease. This antibody has been associated with various forms of vasculitis and neutrophilic dermatosis. Herein, we report a patient who p...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2010.22.1.48

    authors: Seo JW,Son HH,Choi JH,Lee SK

    更新日期:2010-02-01 00:00:00

  • Two Pilosebaceous Cysts with Apocrine Hidrocystoma in One Biopsy Site: A Spectrum of the Same Disease Process?

    abstract::A 28-year-old woman presented with multiple, asymptomatic, erythematous to bluish papules located on the chest. Histopathologically, three round, well defined cystic structures were seen on the upper and lower dermis. The first cyst was milia, the second was apocrine hidrocystoma and the other, largest cyst was an eru...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2008.20.1.11

    authors: Hwang SW,Cho KJ,Oh DJ,Lee D,Kim JW,Park SW

    更新日期:2008-03-01 00:00:00

  • A case of myopericytoma on the lower leg.

    abstract::Myopericytoma (MP) is a benign tumor composed of cells that show apparent differentiation towards putative perivascular myoid cells called myopericytes. It arises most commonly in the dermis or subcutaneous tissue of the extremities in adults. The most common presentation is a well-circumscribed, slow-growing painless...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.2.201

    authors: Paek JO,Kang HS,Yeo KY,Yu HJ,Kim JS

    更新日期:2011-05-01 00:00:00

  • Isolation and Quantification of Glycosaminoglycans from Human Hair Shaft.

    abstract:BACKGROUND:There is evidence that glycosaminoglycans (GAGs) are present in the hair shaft within the follicle but there are no studies regarding GAGs isolation and measurement in the human hair shaft over the scalp surface, it means, in the free hair shaft. OBJECTIVE:The purpose of our research was to isolate and meas...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2016.28.5.533

    authors: Maniatopoulou E,Bonovas S,Sitaras N

    更新日期:2016-10-01 00:00:00

  • Actinomycosis of the upper lip.

    abstract::Actinomycotic infections are known to have an association with difficulties in diagnosis and treatment. These infections usually involve the head, neck, thorax, and abdomen. Actinomycosis of the upper lip is a rare condition and an important one as well, because it can imitate other diseases. As the initial impression...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S1.S131

    authors: Lee YS,Sim HS,Lee SK

    更新日期:2011-09-01 00:00:00

  • Correlation between Severity of Atopic Dermatitis and Sleep Quality in Children and Adults.

    abstract:BACKGROUND:The atopic dermatitis (AD) can limit a patient's physical and psychosocial development as well as lower their overall quality of life (QOL), including sleep quality. OBJECTIVE:The purpose of this study was to evaluate the relationships between clinical disease severity, QOL and sleep quality in children and...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2016.28.3.321

    authors: Kong TS,Han TY,Lee JH,Son SJ

    更新日期:2016-06-01 00:00:00

  • Successful Treatment of Hydroxychloroquine-Induced Recalcitrant Acute Generalized Exanthematous Pustulosis with Cyclosporine: Case Report and Literature Review.

    abstract::Acute generalized exanthematous pustulosis (AGEP) is a cutaneous reaction principally induced by drugs. Spontaneous resolution is observed in most patients. However, severe cases required systemic corticosteroid administration. Hydroxychloroquine, which is used to treat some dermatologic and rheumatologic diseases bec...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2015.27.4.431

    authors: Yalçın B,Çakmak S,Yıldırım B

    更新日期:2015-08-01 00:00:00

  • A case of membranous lipodystrophy observed in lichen amyloidosis.

    abstract::Membranous lipodystrophy is characterized by the presence of microcysts lined by amorphous, eosinophilic material with an arabesque appearance. We experienced a case of a 72-year-old man who had dark brownish, pruritic papules on the arms, legs, and back. Histopathologic examination of a biopsied lesion showed homogen...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2009.21.2.174

    authors: Lee Y,Ahn SY,Ji JH,Hong SP,Bak H,Lee SH,Ahn SK

    更新日期:2009-05-01 00:00:00

  • A malignant melanoma associated with a blue nevus of the lip.

    abstract::Blue nevi are characterized by a collection of pigment-producing melanocytes in the dermis. These lesions clinically present as well demarcated cerulean-blue or bluish black colored papules or plaques that usually measure less than 1 cm in diameter. They are typically found on the dorsal surface of the hands and feet ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2010.22.1.119

    authors: Lee HY,Na SY,Son YM,Kang HK,Baek JO,Lee JR,Roh JY

    更新日期:2010-02-01 00:00:00

  • Effect of Evening Primrose Oil on Korean Patients With Mild Atopic Dermatitis: A Randomized, Double-Blinded, Placebo-Controlled Clinical Study.

    abstract:Background:Atopic dermatitis (AD) is related to a deficiency of delta-6-desaturase, an enzyme responsible for converting linoleic acid to gamma-linolenic acid (GLA). Evening primrose oil (EPO) as a source of GLA has been of interest in the management of AD. Objective:The aim of this randomized, double-blinded, placebo...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2018.30.4.409

    authors: Chung BY,Park SY,Jung MJ,Kim HO,Park CW

    更新日期:2018-08-01 00:00:00

  • Role of keratinocytes in the development of vitiligo.

    abstract::Vitiligo is an acquired depigmentary disorder of the skin that results from the loss of functioning epidermal melanocytes. Most studies on vitiligo have concentrated on the abnormality of melanocytes rather than the abnormality of keratinocytes; however, epidermal melanocytes form a functional and structural unit with...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2012.24.2.115

    authors: Lee AY

    更新日期:2012-05-01 00:00:00

  • Toxic epidermal necrolysis associated with sorafenib and tosufloxacin in a patient with hepatocellular carcinoma.

    abstract::This is the first case report to describe a 44-year-old woman with a history of advanced hepatocellular carcinoma who developed toxic epidermal necrolysis (TEN) clinically after taking 400 mg sorafenib (Nexavar®, BAY 43-9006) and tosufloxacin orally once per day. Both sorafenib and tosufloxacin were eventually discont...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.S3.S404

    authors: Choi MK,Woo HY,Heo J,Cho M,Kim GH,Song GA,Kim MB

    更新日期:2011-12-01 00:00:00

  • Acute Stress-Induced Changes in Follicular Dermal Papilla Cells and Mobilization of Mast Cells: Implications for Hair Growth.

    abstract:BACKGROUND:Stress is a known cause of hair loss in many species. OBJECTIVE:In this study, we investigated the role of acute stress on hair growth using a rat model. METHODS:Rats were immobilized for 24 hours and blood samples, and skin biopsies were taken. The effect of stress-serum on the in vitro proliferation of r...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2016.28.5.600

    authors: Shin H,Choi SJ,Cho AR,Kim DY,Kim KH,Kwon O

    更新日期:2016-10-01 00:00:00

  • Concurrent Drug-Induced Linear Immunoglobulin A Dermatosis and Immunoglobulin A Nephropathy.

    abstract::Diseases associated with immunoglobulin A (IgA) antibody include linear IgA dermatosis, IgA nephropathy, Celiac disease, Henoch-Schönlein purpura, etc. Although usually idiopathic, IgA antibody is occasionally induced by drugs (e.g., vancomycin, carbamazepine, ceftriaxone, and cyclosporine), malignancies, infections, ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2015.27.3.315

    authors: Kim JS,Choi M,Nam CH,Kim JY,Park BC,Kim MH,Hong SP

    更新日期:2015-06-01 00:00:00

  • Differences in the known cellular composition of benign pigmented skin lesions reflected in computer-aided image analysis.

    abstract:BACKGROUND:Computer-aided image analysis (CAIA) has been suggested as an effective diagnostic tool for pigmented skin lesions (PSLs), especially melanoma. However, few studies on benign PSLs have been reported. OBJECTIVE:The purpose of this study was to evaluate benign PSLs with our CAIA software and analyze the diffe...

    journal_title:Annals of dermatology

    pub_type: 杂志文章

    doi:10.5021/ad.2014.26.3.314

    authors: Choi JW,Ryu HH,Byun SY,Youn SW

    更新日期:2014-06-01 00:00:00

  • A Case of Tubular Apocrine Adenoma with Syringocystadenoma Papilliferum that Developed in a Nevus Sebaceus.

    abstract::Tubular apocrine adenoma (TAA) is a very rare sweat gland tumor. TAA and syringocystadenoma papilliferum (SCAP) rarely develop together in a nevus sebaceus (NS). Herein, we report on a 40-year-old Korean woman with TAA associated with SCAP that developed in a NS located on the scalp. ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2010.22.3.319

    authors: Kim MS,Lee JH,Lee WM,Son SJ

    更新日期:2010-08-01 00:00:00

  • Congenital and multiple hobnail hemangiomas.

    abstract::Hobnail hemangioma (targetoid hemosiderotic hemangioma) is a vascular tumor affecting the limbs or trunk. Characteristically, the lesion has a "targetoid" clinical feature and dilated vascular spaces lined by hobnail endothelial cells at histologic examination. The age of onset is widely variable, form 5~67 years, typ...

    journal_title:Annals of dermatology

    pub_type:

    doi:10.5021/ad.2011.23.4.539

    authors: Yoon SY,Kwon HH,Jeon HC,Lee JH,Cho S

    更新日期:2011-11-01 00:00:00